The miR-183 Cluster: Biogenesis, Functions, and Cell Communication via Exosomes in Cancer

Cancer is one of the leading causes of human death. MicroRNAs have been found to be closely associated with cancer. The miR-183 cluster, comprising miR-183, miR-96, and miR-182, is transcribed as a polycistronic miRNA cluster. Importantly, in most cases, these clusters promote cancer development thr...

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Detalles Bibliográficos
Autores principales: Li, Shuhui, Meng, Wei, Guo, Ziyi, Liu, Min, He, Yanyun, Li, Yanli, Ma, Zhongliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177187/
https://www.ncbi.nlm.nih.gov/pubmed/37174715
http://dx.doi.org/10.3390/cells12091315
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author Li, Shuhui
Meng, Wei
Guo, Ziyi
Liu, Min
He, Yanyun
Li, Yanli
Ma, Zhongliang
author_facet Li, Shuhui
Meng, Wei
Guo, Ziyi
Liu, Min
He, Yanyun
Li, Yanli
Ma, Zhongliang
author_sort Li, Shuhui
collection PubMed
description Cancer is one of the leading causes of human death. MicroRNAs have been found to be closely associated with cancer. The miR-183 cluster, comprising miR-183, miR-96, and miR-182, is transcribed as a polycistronic miRNA cluster. Importantly, in most cases, these clusters promote cancer development through different pathways. Exosomes, as extracellular vesicles, play an important role in cellular communication and the regulation of the tissue microenvironment. Interestingly, the miR-183 cluster can be detected in exosomes and plays a functional regulatory role in tumor development. Here, the biogenesis and functions of the miR-183 cluster in highly prevalent cancers and their relationship with other non-coding RNAs are summarized. In addition, the miR-183 cluster in exosomes has also been discussed. Finally, we discuss the miR-183 cluster as a promising target for cancer therapy. This review is expected to provide a new direction for cancer treatment.
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spelling pubmed-101771872023-05-13 The miR-183 Cluster: Biogenesis, Functions, and Cell Communication via Exosomes in Cancer Li, Shuhui Meng, Wei Guo, Ziyi Liu, Min He, Yanyun Li, Yanli Ma, Zhongliang Cells Review Cancer is one of the leading causes of human death. MicroRNAs have been found to be closely associated with cancer. The miR-183 cluster, comprising miR-183, miR-96, and miR-182, is transcribed as a polycistronic miRNA cluster. Importantly, in most cases, these clusters promote cancer development through different pathways. Exosomes, as extracellular vesicles, play an important role in cellular communication and the regulation of the tissue microenvironment. Interestingly, the miR-183 cluster can be detected in exosomes and plays a functional regulatory role in tumor development. Here, the biogenesis and functions of the miR-183 cluster in highly prevalent cancers and their relationship with other non-coding RNAs are summarized. In addition, the miR-183 cluster in exosomes has also been discussed. Finally, we discuss the miR-183 cluster as a promising target for cancer therapy. This review is expected to provide a new direction for cancer treatment. MDPI 2023-05-05 /pmc/articles/PMC10177187/ /pubmed/37174715 http://dx.doi.org/10.3390/cells12091315 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Shuhui
Meng, Wei
Guo, Ziyi
Liu, Min
He, Yanyun
Li, Yanli
Ma, Zhongliang
The miR-183 Cluster: Biogenesis, Functions, and Cell Communication via Exosomes in Cancer
title The miR-183 Cluster: Biogenesis, Functions, and Cell Communication via Exosomes in Cancer
title_full The miR-183 Cluster: Biogenesis, Functions, and Cell Communication via Exosomes in Cancer
title_fullStr The miR-183 Cluster: Biogenesis, Functions, and Cell Communication via Exosomes in Cancer
title_full_unstemmed The miR-183 Cluster: Biogenesis, Functions, and Cell Communication via Exosomes in Cancer
title_short The miR-183 Cluster: Biogenesis, Functions, and Cell Communication via Exosomes in Cancer
title_sort mir-183 cluster: biogenesis, functions, and cell communication via exosomes in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177187/
https://www.ncbi.nlm.nih.gov/pubmed/37174715
http://dx.doi.org/10.3390/cells12091315
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