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Centrosome Formation in the Bovine Early Embryo
Centrosome formation during early development in mice and rats occurs due to the appearance of centrioles de novo. In contrast, in humans and other non-rodent mammals, centrioles are thought to be derived from spermatozoa. Ultrastructural study of zygotes and early embryos of cattle at full series o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177215/ https://www.ncbi.nlm.nih.gov/pubmed/37174735 http://dx.doi.org/10.3390/cells12091335 |
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author | Uzbekov, Rustem Singina, Galina N. Shedova, Ekaterina N. Banliat, Charles Avidor-Reiss, Tomer Uzbekova, Svetlana |
author_facet | Uzbekov, Rustem Singina, Galina N. Shedova, Ekaterina N. Banliat, Charles Avidor-Reiss, Tomer Uzbekova, Svetlana |
author_sort | Uzbekov, Rustem |
collection | PubMed |
description | Centrosome formation during early development in mice and rats occurs due to the appearance of centrioles de novo. In contrast, in humans and other non-rodent mammals, centrioles are thought to be derived from spermatozoa. Ultrastructural study of zygotes and early embryos of cattle at full series of ultrathin sections show that the proximal centriole of the spermatozoon disappears by the end of the first cleavage division. Centrioles appear in two to four cell embryos in fertilized oocytes and in parthenogenetic embryos. Centriole formation includes the appearance of atypical centrioles with randomly arranged triplets and centrioles with microtubule triplets of various lengths. After the third cleavage, four centriolar cylinders appear for the first time in the blastomeres while each embryo still has two atypical centrioles. Our results showed that the mechanisms of centriole formation in different groups of mammals are universal, differing only in the stage of development in which they occur. |
format | Online Article Text |
id | pubmed-10177215 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101772152023-05-13 Centrosome Formation in the Bovine Early Embryo Uzbekov, Rustem Singina, Galina N. Shedova, Ekaterina N. Banliat, Charles Avidor-Reiss, Tomer Uzbekova, Svetlana Cells Article Centrosome formation during early development in mice and rats occurs due to the appearance of centrioles de novo. In contrast, in humans and other non-rodent mammals, centrioles are thought to be derived from spermatozoa. Ultrastructural study of zygotes and early embryos of cattle at full series of ultrathin sections show that the proximal centriole of the spermatozoon disappears by the end of the first cleavage division. Centrioles appear in two to four cell embryos in fertilized oocytes and in parthenogenetic embryos. Centriole formation includes the appearance of atypical centrioles with randomly arranged triplets and centrioles with microtubule triplets of various lengths. After the third cleavage, four centriolar cylinders appear for the first time in the blastomeres while each embryo still has two atypical centrioles. Our results showed that the mechanisms of centriole formation in different groups of mammals are universal, differing only in the stage of development in which they occur. MDPI 2023-05-07 /pmc/articles/PMC10177215/ /pubmed/37174735 http://dx.doi.org/10.3390/cells12091335 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Uzbekov, Rustem Singina, Galina N. Shedova, Ekaterina N. Banliat, Charles Avidor-Reiss, Tomer Uzbekova, Svetlana Centrosome Formation in the Bovine Early Embryo |
title | Centrosome Formation in the Bovine Early Embryo |
title_full | Centrosome Formation in the Bovine Early Embryo |
title_fullStr | Centrosome Formation in the Bovine Early Embryo |
title_full_unstemmed | Centrosome Formation in the Bovine Early Embryo |
title_short | Centrosome Formation in the Bovine Early Embryo |
title_sort | centrosome formation in the bovine early embryo |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177215/ https://www.ncbi.nlm.nih.gov/pubmed/37174735 http://dx.doi.org/10.3390/cells12091335 |
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