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Harnessing the Microbiome to Reduce Pancreatic Cancer Burden

SIMPLE SUMMARY: Pancreatic cancer has one of the worst prognoses among all the malignancies. To date, there are no effective strategies for preventing, diagnosing, or treating this aggressive disease. Increasing evidence shows that the human microbiome influences pancreatic cancer development and th...

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Autores principales: Bastos, Ana Raquel, Pereira-Marques, Joana, Ferreira, Rui Manuel, Figueiredo, Ceu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177253/
https://www.ncbi.nlm.nih.gov/pubmed/37174095
http://dx.doi.org/10.3390/cancers15092629
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author Bastos, Ana Raquel
Pereira-Marques, Joana
Ferreira, Rui Manuel
Figueiredo, Ceu
author_facet Bastos, Ana Raquel
Pereira-Marques, Joana
Ferreira, Rui Manuel
Figueiredo, Ceu
author_sort Bastos, Ana Raquel
collection PubMed
description SIMPLE SUMMARY: Pancreatic cancer has one of the worst prognoses among all the malignancies. To date, there are no effective strategies for preventing, diagnosing, or treating this aggressive disease. Increasing evidence shows that the human microbiome influences pancreatic cancer development and the response to treatment, which is the main aim of this review. Future studies will be key to determining whether or not this knowledge might be used to develop new strategies that harness the microbiome for diagnostic and therapeutic interventions in pancreatic cancer. ABSTRACT: Pancreatic cancer mortality is expected to rise in the next decades. This aggressive malignancy has a dismal prognosis due to late diagnosis and resistance to treatment. Increasing evidence indicates that host–microbiome interactions play an integral role in pancreatic cancer development, suggesting that harnessing the microbiome might offer promising opportunities for diagnostic and therapeutic interventions. Herein, we review the associations between pancreatic cancer and the intratumoral, gut and oral microbiomes. We also explore the mechanisms with which microbes influence cancer development and the response to treatment. We further discuss the potentials and limitations of using the microbiome as a target for therapeutic interventions, in order to improve pancreatic cancer patient outcomes.
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spelling pubmed-101772532023-05-13 Harnessing the Microbiome to Reduce Pancreatic Cancer Burden Bastos, Ana Raquel Pereira-Marques, Joana Ferreira, Rui Manuel Figueiredo, Ceu Cancers (Basel) Review SIMPLE SUMMARY: Pancreatic cancer has one of the worst prognoses among all the malignancies. To date, there are no effective strategies for preventing, diagnosing, or treating this aggressive disease. Increasing evidence shows that the human microbiome influences pancreatic cancer development and the response to treatment, which is the main aim of this review. Future studies will be key to determining whether or not this knowledge might be used to develop new strategies that harness the microbiome for diagnostic and therapeutic interventions in pancreatic cancer. ABSTRACT: Pancreatic cancer mortality is expected to rise in the next decades. This aggressive malignancy has a dismal prognosis due to late diagnosis and resistance to treatment. Increasing evidence indicates that host–microbiome interactions play an integral role in pancreatic cancer development, suggesting that harnessing the microbiome might offer promising opportunities for diagnostic and therapeutic interventions. Herein, we review the associations between pancreatic cancer and the intratumoral, gut and oral microbiomes. We also explore the mechanisms with which microbes influence cancer development and the response to treatment. We further discuss the potentials and limitations of using the microbiome as a target for therapeutic interventions, in order to improve pancreatic cancer patient outcomes. MDPI 2023-05-05 /pmc/articles/PMC10177253/ /pubmed/37174095 http://dx.doi.org/10.3390/cancers15092629 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bastos, Ana Raquel
Pereira-Marques, Joana
Ferreira, Rui Manuel
Figueiredo, Ceu
Harnessing the Microbiome to Reduce Pancreatic Cancer Burden
title Harnessing the Microbiome to Reduce Pancreatic Cancer Burden
title_full Harnessing the Microbiome to Reduce Pancreatic Cancer Burden
title_fullStr Harnessing the Microbiome to Reduce Pancreatic Cancer Burden
title_full_unstemmed Harnessing the Microbiome to Reduce Pancreatic Cancer Burden
title_short Harnessing the Microbiome to Reduce Pancreatic Cancer Burden
title_sort harnessing the microbiome to reduce pancreatic cancer burden
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177253/
https://www.ncbi.nlm.nih.gov/pubmed/37174095
http://dx.doi.org/10.3390/cancers15092629
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