Cargando…

Senescent Cells: A Therapeutic Target in Cardiovascular Diseases

Senescent cell accumulation has been observed in age-associated diseases including cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence-associated secretory phenotype (SASP) factors that may cause or worsen many cardiovascular diseases. Therapies targeting sene...

Descripción completa

Detalles Bibliográficos
Autores principales:	Suda, Masayoshi, Paul, Karl H., Minamino, Tohru, Miller, Jordan D., Lerman, Amir, Ellison-Hughes, Georgina M., Tchkonia, Tamar, Kirkland, James L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177324/ https://www.ncbi.nlm.nih.gov/pubmed/37174697 http://dx.doi.org/10.3390/cells12091296

Ejemplares similares

Targeting cellular senescence in metabolic disease
por: Palmer, Allyson K., et al.
Publicado: (2022)

Cell senescence, the senescence-associated secretory phenotype, and cancers
por: Langhi Prata, Larissa G. P., et al.
Publicado: (2023)

CELLULAR SENESCENCE AS A THERAPEUTIC TARGET FOR GEROSCIENCE-GUIDED CLINICAL TRIALS
por: Justice, Jamie N, et al.
Publicado: (2019)

Cellular Senescence: A Translational Perspective
por: Kirkland, James L., et al.
Publicado: (2017)

COVID-19 and cellular senescence
por: Schmitt, Clemens A., et al.
Publicado: (2022)

Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities
por: Song, Shuling, et al.
Publicado: (2020)

Growth hormone in adipose dysfunction and senescence
por: Stout, Michael B., et al.
Publicado: (2015)

Targeting Cell Senescence to Improve Cardiac Regeneration
por: Ellison-Hughes, Georgina M.
Publicado: (2023)

Vascular Senescence in Cardiovascular and Metabolic Diseases
por: Katsuumi, Goro, et al.
Publicado: (2018)

Effect of Combined Dasatinib and Fisetin Treatment on Senescent Cell Clearance in Monkeys
por: Colman, Ricki, et al.
Publicado: (2020)

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity
por: Palmer, Allyson K., et al.
Publicado: (2015)

Aged‐senescent cells contribute to impaired heart regeneration
por: Lewis‐McDougall, Fiona C., et al.
Publicado: (2019)

New agents that target senescent cells: the flavone, fisetin, and the BCL-X(L) inhibitors, A1331852 and A1155463
por: Zhu, Yi, et al.
Publicado: (2017)

Deleted in Breast Cancer 1 regulates cellular senescence during obesity
por: Escande, Carlos, et al.
Publicado: (2014)

Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies
por: Wyld, Lynda, et al.
Publicado: (2020)

Targeting senescent cells enhances adipogenesis and metabolic function in old age
por: Xu, Ming, et al.
Publicado: (2015)

TNF‐α/IFN‐γ synergy amplifies senescence‐associated inflammation and SARS‐CoV‐2 receptor expression via hyper‐activated JAK/STAT1
por: Kandhaya‐Pillai, Renuka, et al.
Publicado: (2022)

Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia
por: Suvakov, Sonja, et al.
Publicado: (2019)

Cellular Senescence in Arterial Diseases
por: Shimizu, Ippei, et al.
Publicado: (2020)

Cellular senescence in skin‐related research: Targeted signaling pathways and naturally occurring therapeutic agents
por: Dańczak‐Pazdrowska, Aleksandra, et al.
Publicado: (2023)

Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells
por: Conley, Sabena M., et al.
Publicado: (2020)

A chronic wound model to investigate skin cellular senescence
por: Wyles, Saranya P., et al.
Publicado: (2023)

Palmitate induces DNA damage and senescence in human adipocytes in vitro that can be alleviated by oleic acid but not inorganic nitrate
por: Ishaq, Abbas, et al.
Publicado: (2022)

First evidence that senolytics are effective at decreasing senescent cells in humans
por: Ellison-Hughes, Georgina M.
Publicado: (2020)

Senolytics: Potential for Alleviating Diabetes and Its Complications
por: Palmer, Allyson K, et al.
Publicado: (2021)

Role of senescence in the chronic health consequences of COVID-19
por: Wissler Gerdes, Erin O., et al.
Publicado: (2022)

Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex
por: Kandhaya-Pillai, Renuka, et al.
Publicado: (2023)

Cellular senescence: the good, the bad and the unknown
por: Huang, Weijun, et al.
Publicado: (2022)

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice
por: Xu, Ming, et al.
Publicado: (2017)

Fat tissue, aging, and cellular senescence
por: Tchkonia, Tamara, et al.
Publicado: (2010)

Capillaries as a Therapeutic Target for Heart Failure
por: Yoshida, Yohko, et al.
Publicado: (2022)

Targeting cellular senescence prevents age-related bone loss in mice
por: Farr, Joshua N., et al.
Publicado: (2017)

In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers
por: Samakkarnthai, Parinya, et al.
Publicado: (2023)

BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH
por: Baboota, Ritesh K., et al.
Publicado: (2022)

Discovery, development, and future application of senolytics: theories and predictions
por: Wissler Gerdes, Erin O., et al.
Publicado: (2020)

Quercetin Reverses Cardiac Systolic Dysfunction in Mice Fed with a High-Fat Diet: Role of Angiogenesis
por: Yu, Shasha, et al.
Publicado: (2021)

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction
por: Palmer, Allyson K., et al.
Publicado: (2019)

Glycoprotein nonmetastatic melanoma protein B regulates lysosomal integrity and lifespan of senescent cells
por: Suda, Masayoshi, et al.
Publicado: (2022)

Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease
por: Cianflone, Eleonora, et al.
Publicado: (2020)

SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3
por: Tripathi, Utkarsh, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_pa5oisr5nk97m2bv2sv5ia8596