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Magnetic Resonance Imaging Features of Rhino-Orbito-Cerebral Mucormycosis in Post-COVID-19 Patients: Radio-Pathological Correlation

There has been a notable increase in rhino-orbito-cerebral mucormycosis (ROCM) post-coronavirus disease 2019 (COVID-19), which is an invasive fungal infection with a fatal outcome. Magnetic resonance imaging (MRI) is a valuable tool for early diagnosis of ROCM and assists in the proper management of...

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Autores principales: Hassan, Rania Mostafa, Almalki, Yassir Edrees, Basha, Mohammad Abd Alkhalik, Gobran, Mai Ahmed, Alqahtani, Saad Misfer, Assiri, Abdullah M., Alqahtani, Saeed, Alduraibi, Sharifa Khalid, Aboualkheir, Mervat, Almushayti, Ziyad A., Aldhilan, Asim S., Aly, Sameh Abdelaziz, Alshamy, Asmaa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177362/
https://www.ncbi.nlm.nih.gov/pubmed/37174937
http://dx.doi.org/10.3390/diagnostics13091546
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author Hassan, Rania Mostafa
Almalki, Yassir Edrees
Basha, Mohammad Abd Alkhalik
Gobran, Mai Ahmed
Alqahtani, Saad Misfer
Assiri, Abdullah M.
Alqahtani, Saeed
Alduraibi, Sharifa Khalid
Aboualkheir, Mervat
Almushayti, Ziyad A.
Aldhilan, Asim S.
Aly, Sameh Abdelaziz
Alshamy, Asmaa A.
author_facet Hassan, Rania Mostafa
Almalki, Yassir Edrees
Basha, Mohammad Abd Alkhalik
Gobran, Mai Ahmed
Alqahtani, Saad Misfer
Assiri, Abdullah M.
Alqahtani, Saeed
Alduraibi, Sharifa Khalid
Aboualkheir, Mervat
Almushayti, Ziyad A.
Aldhilan, Asim S.
Aly, Sameh Abdelaziz
Alshamy, Asmaa A.
author_sort Hassan, Rania Mostafa
collection PubMed
description There has been a notable increase in rhino-orbito-cerebral mucormycosis (ROCM) post-coronavirus disease 2019 (COVID-19), which is an invasive fungal infection with a fatal outcome. Magnetic resonance imaging (MRI) is a valuable tool for early diagnosis of ROCM and assists in the proper management of these cases. This study aimed to describe the characteristic MRI findings of ROCM in post-COVID-19 patients to help in the early diagnosis and management of these patients. This retrospective descriptive study was conducted at a single hospital and included 52 patients with COVID-19 and a histopathologically proven ROCM infection who were referred for an MRI of the paranasal sinuses (PNS) due to sino-orbital manifestations. Two radiologists reviewed all the MR images in consensus. The diagnosis was confirmed by histopathological examination. The maxillary sinus was the most commonly affected PNS (96.2%). In most patients (57.7%), multiple sinuses were involved with the black turbinate sign on postcontrast images. Extrasinus was evident in 43 patients with orbital involvement. The pterygopalatine fossa was involved in four patients. Three patients had cavernous sinus extension, two had pachymeningeal enhancement, and one had epidural collection. The alveolar margin was affected in two patients, and five patients had an extension to the cheek. The awareness of radiologists by the characteristic MRI features of ROCM in post-COVID-19 patients helps in early detection, early proper management, and prevention of morbid complications.
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spelling pubmed-101773622023-05-13 Magnetic Resonance Imaging Features of Rhino-Orbito-Cerebral Mucormycosis in Post-COVID-19 Patients: Radio-Pathological Correlation Hassan, Rania Mostafa Almalki, Yassir Edrees Basha, Mohammad Abd Alkhalik Gobran, Mai Ahmed Alqahtani, Saad Misfer Assiri, Abdullah M. Alqahtani, Saeed Alduraibi, Sharifa Khalid Aboualkheir, Mervat Almushayti, Ziyad A. Aldhilan, Asim S. Aly, Sameh Abdelaziz Alshamy, Asmaa A. Diagnostics (Basel) Article There has been a notable increase in rhino-orbito-cerebral mucormycosis (ROCM) post-coronavirus disease 2019 (COVID-19), which is an invasive fungal infection with a fatal outcome. Magnetic resonance imaging (MRI) is a valuable tool for early diagnosis of ROCM and assists in the proper management of these cases. This study aimed to describe the characteristic MRI findings of ROCM in post-COVID-19 patients to help in the early diagnosis and management of these patients. This retrospective descriptive study was conducted at a single hospital and included 52 patients with COVID-19 and a histopathologically proven ROCM infection who were referred for an MRI of the paranasal sinuses (PNS) due to sino-orbital manifestations. Two radiologists reviewed all the MR images in consensus. The diagnosis was confirmed by histopathological examination. The maxillary sinus was the most commonly affected PNS (96.2%). In most patients (57.7%), multiple sinuses were involved with the black turbinate sign on postcontrast images. Extrasinus was evident in 43 patients with orbital involvement. The pterygopalatine fossa was involved in four patients. Three patients had cavernous sinus extension, two had pachymeningeal enhancement, and one had epidural collection. The alveolar margin was affected in two patients, and five patients had an extension to the cheek. The awareness of radiologists by the characteristic MRI features of ROCM in post-COVID-19 patients helps in early detection, early proper management, and prevention of morbid complications. MDPI 2023-04-25 /pmc/articles/PMC10177362/ /pubmed/37174937 http://dx.doi.org/10.3390/diagnostics13091546 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hassan, Rania Mostafa
Almalki, Yassir Edrees
Basha, Mohammad Abd Alkhalik
Gobran, Mai Ahmed
Alqahtani, Saad Misfer
Assiri, Abdullah M.
Alqahtani, Saeed
Alduraibi, Sharifa Khalid
Aboualkheir, Mervat
Almushayti, Ziyad A.
Aldhilan, Asim S.
Aly, Sameh Abdelaziz
Alshamy, Asmaa A.
Magnetic Resonance Imaging Features of Rhino-Orbito-Cerebral Mucormycosis in Post-COVID-19 Patients: Radio-Pathological Correlation
title Magnetic Resonance Imaging Features of Rhino-Orbito-Cerebral Mucormycosis in Post-COVID-19 Patients: Radio-Pathological Correlation
title_full Magnetic Resonance Imaging Features of Rhino-Orbito-Cerebral Mucormycosis in Post-COVID-19 Patients: Radio-Pathological Correlation
title_fullStr Magnetic Resonance Imaging Features of Rhino-Orbito-Cerebral Mucormycosis in Post-COVID-19 Patients: Radio-Pathological Correlation
title_full_unstemmed Magnetic Resonance Imaging Features of Rhino-Orbito-Cerebral Mucormycosis in Post-COVID-19 Patients: Radio-Pathological Correlation
title_short Magnetic Resonance Imaging Features of Rhino-Orbito-Cerebral Mucormycosis in Post-COVID-19 Patients: Radio-Pathological Correlation
title_sort magnetic resonance imaging features of rhino-orbito-cerebral mucormycosis in post-covid-19 patients: radio-pathological correlation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177362/
https://www.ncbi.nlm.nih.gov/pubmed/37174937
http://dx.doi.org/10.3390/diagnostics13091546
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