A Non-Canonical Role for the Glycosyltransferase Enzyme UGT2B17 as a Novel Constituent of the B Cell Receptor Signalosome

In chronic lymphocytic leukemia (CLL), an elevated glycosyltransferase UGT2B17 expression (UGT2B17(HI)) identifies a subgroup of patients with shorter survival and poor drug response. We uncovered a mechanism, possibly independent of its enzymatic function, characterized by an enhanced expression an...

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Detalles Bibliográficos
Autores principales: Wagner, Antoine, Rouleau, Michèle, Villeneuve, Lyne, Le, Trang, Peltier, Cheryl, Allain, Éric P., Beaudoin, Caroline, Tremblay, Sophie, Courtier, Fréderic, Nguyen Van Long, Flora, Laverdière, Isabelle, Lévesque, Éric, Banerji, Versha, Vanura, Katrina, Guillemette, Chantal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177405/
https://www.ncbi.nlm.nih.gov/pubmed/37174695
http://dx.doi.org/10.3390/cells12091295

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