Therapies beyond Physiological Barriers and Drug Resistance: A Pilot Study and Review of the Literature Investigating If Intrathecal Trastuzumab and New Treatment Options Can Improve Oncologic Outcomes in Leptomeningeal Metastases from HER2-Positive Breast Cancer

SIMPLE SUMMARY: Approximately 10% of HER2-positive breast cancer patients will develop leptomeningeal metastases (LM), characterized by the spread of tumor cells within the leptomeninges and subarachnoid space. Historically, patients with HER2-positive breast cancer and LM have been excluded from st...

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Detalles Bibliográficos
Autores principales: Trifănescu, Oana Gabriela, Mitrea, Dan, Galeș, Laurenția Nicoleta, Ciornei, Ana, Păun, Mihai-Andrei, Butnariu, Ioana, Trifănescu, Raluca Alexandra, Motaș, Natalia, Toma, Radu Valeriu, Bîlteanu, Liviu, Gherghe, Mirela, Anghel, Rodica Maricela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177464/
https://www.ncbi.nlm.nih.gov/pubmed/37173973
http://dx.doi.org/10.3390/cancers15092508

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