Cargando…

A Phase I Dose Escalation and Expansion Study of Epidiolex (Cannabidiol) in Patients with Biochemically Recurrent Prostate Cancer

SIMPLE SUMMARY: Cannabinoids have been widely used for pain, nausea, and appetite stimulation, and have also shown anti-tumor activity in preclinical studies of prostate cancer. Epidiolex is an oral cannabidiol solution that is FDA approved for the treatment of certain types of seizures in patients...

Descripción completa

Detalles Bibliográficos
Autores principales:	Myint, Zin W., St. Clair, William H., Strup, Stephen E., Yan, Donglin, Li, Ning, Allison, Derek B., McLouth, Laurie E., Ellis, Carleton S., Wang, Peng, James, Andrew C., Hensley, Patrick J., Otto, Danielle E., Arnold, Susanne M., DiPaola, Robert S., Kolesar, Jill M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177512/ https://www.ncbi.nlm.nih.gov/pubmed/37173971 http://dx.doi.org/10.3390/cancers15092505

Ejemplares similares

Correlation Between Trough Level of Abiraterone and Prostate-Specific Antigen (PSA) Response in Metastatic Hormone-Sensitive Prostate Cancer
por: Myint, Zin W., et al.
Publicado: (2022)

Evaluation of Glutaminase Expression in Prostate Adenocarcinoma and Correlation with Clinicopathologic Parameters
por: Myint, Zin W., et al.
Publicado: (2021)

Evaluation of Fall and Fracture Risk Among Men With Prostate Cancer Treated With Androgen Receptor Inhibitors: A Systematic Review and Meta-analysis
por: Myint, Zin W., et al.
Publicado: (2020)

Epidiolex as adjunct therapy for treatment of refractory epilepsy: a comprehensive review with a focus on adverse effects
por: Sekar, Krithiga, et al.
Publicado: (2019)

Pharmacokinetics of escalating single‐dose administration of cannabidiol to cats
por: Rozental, Aaron J., et al.
Publicado: (2022)

A review on the syntheses of Dronabinol and Epidiolex as classical cannabinoids with various biological activities including those against SARS-COV2
por: Tadayon, Neda, et al.
Publicado: (2021)

A Web-Based, Positive Emotion Skills Intervention for Enhancing Posttreatment Psychological Well-Being in Young Adult Cancer Survivors (EMPOWER): Protocol for a Single-Arm Feasibility Trial
por: Salsman, John M, et al.
Publicado: (2020)

Coverage and Cost-of-Care Links: Addressing Financial Toxicity Among Patients With Hematologic Cancer and Their Caregivers
por: Edward, Jean S., et al.
Publicado: (2023)

A Case Report of Metastatic Castration-Resistant Prostate Cancer Harboring a PTEN Loss
por: Myint, Zin W., et al.
Publicado: (2021)

Association of CD47 Expression with Clinicopathologic Characteristics and Survival Outcomes in Muscle Invasive Bladder Cancer
por: Myint, Zin W., et al.
Publicado: (2023)

A single arm phase II study of bone-targeted Sn-117 m-DTPA in symptomatic castration-resistant prostate cancer with skeletal metastases
por: Myint, Zin W., et al.
Publicado: (2022)

Case Report: Safety and Efficacy of Enfortumab Vedotin in a Patient With Metastatic Urothelial Carcinoma Undergoing Peritoneal Dialysis
por: Collette, Kaylyn R., et al.
Publicado: (2022)

Validation of a Deep Learning Tool in the Detection of Intracranial Hemorrhage and Large Vessel Occlusion
por: McLouth, Joel, et al.
Publicado: (2021)

Utility of cerebrospinal fluid lactate in aneurysmal subarachnoid hemorrhage
por: Renfrow, Jaclyn J., et al.
Publicado: (2018)

2.20 Use of the Columbia-Suicide Severity Rating Scale (C-SSRS) With Adolescent Patients During the COVID-19 Pandemic at University of Kentucky Healthcare
por: Moore, Kelly, et al.
Publicado: (2022)

The protocol for the Cannabidiol in children with refractory epileptic encephalopathy (CARE-E) study: a phase 1 dosage escalation study
por: Reithmeier, Darren, et al.
Publicado: (2018)

Commentary: Use of BACTRAC Proteomic Database-Uromodulin Protein Expression During Ischemic Stroke
por: Armstrong, Gabriella-Salome K., et al.
Publicado: (2021)

Prostate SBRT using O‐Ring Halcyon Linac — Plan quality, delivery efficiency, and accuracy
por: Pokhrel, Damodar, et al.
Publicado: (2020)

Hemorrhagic stroke outcomes of KApSR patients with co-morbid diabetes and Alzheimer’s disease
por: Trout, Amanda L., et al.
Publicado: (2021)

Therapeutic treatment with the anti-inflammatory drug candidate MW151 may partially reduce memory impairment and normalizes hippocampal metabolic markers in a mouse model of comorbid amyloid and vascular pathology
por: Braun, David J., et al.
Publicado: (2022)

A Phase 1, Randomised, Placebo-Controlled, Dose Escalation Study to Investigate the Safety, Tolerability and Pharmacokinetics of Cannabidiol in Fed Healthy Volunteers
por: Perkins, Daniel, et al.
Publicado: (2020)

Influence of spontaneous splenorenal shunts on clinical outcomes in decompensated cirrhosis and after liver transplantation
por: Saks, Karen, et al.
Publicado: (2018)

The Effects of Food on Cannabidiol Bioaccessibility
por: Mozaffari, Khadijeh, et al.
Publicado: (2021)

Proteomic changes in intracranial blood during human ischemic stroke
por: Maglinger, Benton, et al.
Publicado: (2021)

Short Chain Fatty Acids Taken at Time of Thrombectomy in Acute Ischemic Stroke Patients Are Independent of Stroke Severity But Associated With Inflammatory Markers and Worse Symptoms at Discharge
por: Henry, Nicholas, et al.
Publicado: (2022)

The cannabidiol and marijuana research expansion act: Promotion of scientific knowledge to prevent a national health crisis
por: Purcell, John M., et al.
Publicado: (2022)

Prevalence of SARS-CoV-2 IgG antibodies in health care workers at a tertiary care academic medical center – An assessment of occupational infection risk
por: Forster, Derek, et al.
Publicado: (2021)

Direct delivery of an investigational cell therapy in patients with Parkinson’s disease: an interim analysis of feasibility and safety of an open-label study using DBS-Plus clinical trial design
por: Quintero, Jorge E, et al.
Publicado: (2022)

Palliative care use and utilization determinants among patients treated for advanced stage lung cancer care in the community and academic medical setting
por: McLouth, Laurie E., et al.
Publicado: (2023)

Cannabidiol and Cannabidiol Metabolites: Pharmacokinetics, Interaction with Food, and Influence on Liver Function
por: Abbotts, Kieran Shay Struebin, et al.
Publicado: (2022)

Intracranial VCAM1 at time of mechanical thrombectomy predicts ischemic stroke severity
por: Maglinger, Benton, et al.
Publicado: (2021)

Real de-escalation or escalation in disguise?
por: Banys-Paluchowski, Maggie, et al.
Publicado: (2023)

Cannabidiol (CBD) and Insomnia : Literature review
por: Gutierrez Higueras, T., et al.
Publicado: (2022)

Tolerability and Efficacy of a 10:25 Preparation of Δ9-Tetrahydrocannabinol and Cannabidiol for Treatment of Chronic Back or Neck Pain: A Multiple-Dose Escalation Study
por: Glare, Paul, et al.
Publicado: (2023)

Cannabidiol in Parkinson’s disease
por: Rieder, Carlos R.
Publicado: (2020)

The antimicrobial potential of cannabidiol
por: Blaskovich, Mark A. T., et al.
Publicado: (2021)

Cannabidiol in the Treatment of Epilepsy
por: von Wrede, Randi, et al.
Publicado: (2021)

The Polypharmacological Effects of Cannabidiol
por: Castillo-Arellano, Jorge, et al.
Publicado: (2023)

Development of a Functional Assessment of Chronic Illness Therapy item library and primary symptom list for the assessment of patient-reported adverse events associated with immune checkpoint modulators
por: Webster, Kimberly A., et al.
Publicado: (2020)

Reasons for using cannabidiol: a cross-sectional study of French cannabidiol users
por: Fortin, Davide, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_uhl2pngv0kn8bso4vhd2b63ba4