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Updated Epidemiology of Gastric Cancer in Asia: Decreased Incidence but Still a Big Challenge

SIMPLE SUMMARY: Gastric cancer (GC) is regarded as one of the most perilous malignancies globally, with over one billion new cases and seven hundred and eighty-three thousand deaths reported in 2020. The incidence of GC is particularly high in Asian countries. Moreover, multiple oncogenic signaling...

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Autores principales: Shin, Wing Sum, Xie, Fuda, Chen, Bonan, Yu, Peiyao, Yu, Jun, To, Ka Fai, Kang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177574/
https://www.ncbi.nlm.nih.gov/pubmed/37174105
http://dx.doi.org/10.3390/cancers15092639
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author Shin, Wing Sum
Xie, Fuda
Chen, Bonan
Yu, Peiyao
Yu, Jun
To, Ka Fai
Kang, Wei
author_facet Shin, Wing Sum
Xie, Fuda
Chen, Bonan
Yu, Peiyao
Yu, Jun
To, Ka Fai
Kang, Wei
author_sort Shin, Wing Sum
collection PubMed
description SIMPLE SUMMARY: Gastric cancer (GC) is regarded as one of the most perilous malignancies globally, with over one billion new cases and seven hundred and eighty-three thousand deaths reported in 2020. The incidence of GC is particularly high in Asian countries. Moreover, multiple oncogenic signaling pathways are activated and implicated in gastric carcinogenesis, leading to malignant phenotype acquisition. This review outlines the most updated epidemiology of GC in Asian countries, along with targeted therapies for GC treatment. ABSTRACT: Despite the decline in incidence and mortality rates, gastric cancer (GC) is the fifth leading cause of cancer deaths worldwide. The incidence and mortality of GC are exceptionally high in Asia due to high H. pylori infection, dietary habits, smoking behaviors, and heavy alcohol consumption. In Asia, males are more susceptible to developing GC than females. Variations in H. pylori strains and prevalence rates may contribute to the differences in incidence and mortality rates across Asian countries. Large-scale H. pylori eradication was one of the effective ways to reduce GC incidences. Treatment methods and clinical trials have evolved, but the 5-year survival rate of advanced GC is still low. Efforts should be put towards large-scale screening and early diagnosis, precision medicine, and deep mechanism studies on the interplay of GC cells and microenvironments for dealing with peritoneal metastasis and prolonging patients’ survival.
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spelling pubmed-101775742023-05-13 Updated Epidemiology of Gastric Cancer in Asia: Decreased Incidence but Still a Big Challenge Shin, Wing Sum Xie, Fuda Chen, Bonan Yu, Peiyao Yu, Jun To, Ka Fai Kang, Wei Cancers (Basel) Review SIMPLE SUMMARY: Gastric cancer (GC) is regarded as one of the most perilous malignancies globally, with over one billion new cases and seven hundred and eighty-three thousand deaths reported in 2020. The incidence of GC is particularly high in Asian countries. Moreover, multiple oncogenic signaling pathways are activated and implicated in gastric carcinogenesis, leading to malignant phenotype acquisition. This review outlines the most updated epidemiology of GC in Asian countries, along with targeted therapies for GC treatment. ABSTRACT: Despite the decline in incidence and mortality rates, gastric cancer (GC) is the fifth leading cause of cancer deaths worldwide. The incidence and mortality of GC are exceptionally high in Asia due to high H. pylori infection, dietary habits, smoking behaviors, and heavy alcohol consumption. In Asia, males are more susceptible to developing GC than females. Variations in H. pylori strains and prevalence rates may contribute to the differences in incidence and mortality rates across Asian countries. Large-scale H. pylori eradication was one of the effective ways to reduce GC incidences. Treatment methods and clinical trials have evolved, but the 5-year survival rate of advanced GC is still low. Efforts should be put towards large-scale screening and early diagnosis, precision medicine, and deep mechanism studies on the interplay of GC cells and microenvironments for dealing with peritoneal metastasis and prolonging patients’ survival. MDPI 2023-05-06 /pmc/articles/PMC10177574/ /pubmed/37174105 http://dx.doi.org/10.3390/cancers15092639 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shin, Wing Sum
Xie, Fuda
Chen, Bonan
Yu, Peiyao
Yu, Jun
To, Ka Fai
Kang, Wei
Updated Epidemiology of Gastric Cancer in Asia: Decreased Incidence but Still a Big Challenge
title Updated Epidemiology of Gastric Cancer in Asia: Decreased Incidence but Still a Big Challenge
title_full Updated Epidemiology of Gastric Cancer in Asia: Decreased Incidence but Still a Big Challenge
title_fullStr Updated Epidemiology of Gastric Cancer in Asia: Decreased Incidence but Still a Big Challenge
title_full_unstemmed Updated Epidemiology of Gastric Cancer in Asia: Decreased Incidence but Still a Big Challenge
title_short Updated Epidemiology of Gastric Cancer in Asia: Decreased Incidence but Still a Big Challenge
title_sort updated epidemiology of gastric cancer in asia: decreased incidence but still a big challenge
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177574/
https://www.ncbi.nlm.nih.gov/pubmed/37174105
http://dx.doi.org/10.3390/cancers15092639
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