IL-22-Activated MUC13 Impacts on Colonic Barrier Function through JAK1/STAT3, SNAI1/ZEB1 and ROCK2/MAPK Signaling

Overexpression of the transmembrane mucin MUC13, as seen in inflammatory bowel diseases (IBD), could potentially impact barrier function. This study aimed to explore how inflammation-induced MUC13 disrupts epithelial barrier integrity by affecting junctional protein expression in IBD, thereby also c...

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Detalles Bibliográficos
Autores principales: Breugelmans, Tom, Arras, Wout, Oosterlinck, Baptiste, Jauregui-Amezaga, Aranzazu, Somers, Michaël, Cuypers, Bart, Laukens, Kris, De Man, Joris G., De Schepper, Heiko U., De Winter, Benedicte Y., Smet, Annemieke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177587/
https://www.ncbi.nlm.nih.gov/pubmed/37174625
http://dx.doi.org/10.3390/cells12091224

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