Concurrent Activation of Both Survival-Promoting and Death-Inducing Signaling by Chloroquine in Glioblastoma Stem Cells: Implications for Potential Risks and Benefits of Using Chloroquine as Radiosensitizer

Lysosomotropic agent chloroquine was shown to sensitize non-stem glioblastoma cells to radiation in vitro with p53-dependent apoptosis implicated as one of the underlying mechanisms. The in vivo outcomes of chloroquine or its effects on glioblastoma stem cells have not been previously addressed. Thi...

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Detalles Bibliográficos
Autores principales: Müller, Andreas, Weyerhäuser, Patrick, Berte, Nancy, Jonin, Fitriasari, Lyubarskyy, Bogdan, Sprang, Bettina, Kantelhardt, Sven Rainer, Salinas, Gabriela, Opitz, Lennart, Schulz-Schaeffer, Walter, Giese, Alf, Kim, Ella L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177603/
https://www.ncbi.nlm.nih.gov/pubmed/37174691
http://dx.doi.org/10.3390/cells12091290

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