Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2′,3′:4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity

Topoisomerases II are ubiquitous enzymes with significant genotoxic effects in many critical DNA processes. Additionally, epidermal growth factor receptor (EGFR) plays pivotal role in tumour growth and angiogenesis. A novel series of naphtho[2',3':4,5]thiazolo[3,2-a]pyrimidine hybrids have...

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Detalles Bibliográficos
Autores principales: Mourad, Mai A. E., Abo Elmaaty, Ayman, Zaki, Islam, Mourad, Ahmed A. E., Hofni, Amal, Khodir, Ahmed E., Aboubakr, Esam M., Elkamhawy, Ahmed, Roh, Eun Joo, Al-Karmalawy, Ahmed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177692/
https://www.ncbi.nlm.nih.gov/pubmed/37165800
http://dx.doi.org/10.1080/14756366.2023.2205043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177692/
https://www.ncbi.nlm.nih.gov/pubmed/37165800
http://dx.doi.org/10.1080/14756366.2023.2205043

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