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Immature Teratoma: Diagnosis and Management—A Review of the Literature

An immature teratoma is a germinal malignant tumor composed of three germ cell layers, occurring more frequently in young women. It is the second most frequent among the malignant germinal tumors after dysgerminoma, and it is the only neoplasm with germ cells that are histologically graded. Even if...

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Autores principales: Moraru, Liviu, Mitranovici, Melinda-Ildiko, Chiorean, Diana Maria, Coroș, Marius, Moraru, Raluca, Oală, Ioan Emilian, Turdean, Sabin Gligore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177811/
https://www.ncbi.nlm.nih.gov/pubmed/37174909
http://dx.doi.org/10.3390/diagnostics13091516
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author Moraru, Liviu
Mitranovici, Melinda-Ildiko
Chiorean, Diana Maria
Coroș, Marius
Moraru, Raluca
Oală, Ioan Emilian
Turdean, Sabin Gligore
author_facet Moraru, Liviu
Mitranovici, Melinda-Ildiko
Chiorean, Diana Maria
Coroș, Marius
Moraru, Raluca
Oală, Ioan Emilian
Turdean, Sabin Gligore
author_sort Moraru, Liviu
collection PubMed
description An immature teratoma is a germinal malignant tumor composed of three germ cell layers, occurring more frequently in young women. It is the second most frequent among the malignant germinal tumors after dysgerminoma, and it is the only neoplasm with germ cells that are histologically graded. Even if we do not have a consensus regarding its therapeutical management, it has a good prognosis, with an excellent overall survival rate and good fertility preservation. More studies are needed regarding the necessity of adjuvant chemotherapy in pediatric oncology, and because of chemotherapy’s long-term adverse effects, surveillance or a targeted treatment is preferred, but the main therapy is fertility-sparing surgery. Special attention should be given to the genetic mapping of the histological pieces for patient risk stratification due to its value in prognosis and future treatment.
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spelling pubmed-101778112023-05-13 Immature Teratoma: Diagnosis and Management—A Review of the Literature Moraru, Liviu Mitranovici, Melinda-Ildiko Chiorean, Diana Maria Coroș, Marius Moraru, Raluca Oală, Ioan Emilian Turdean, Sabin Gligore Diagnostics (Basel) Review An immature teratoma is a germinal malignant tumor composed of three germ cell layers, occurring more frequently in young women. It is the second most frequent among the malignant germinal tumors after dysgerminoma, and it is the only neoplasm with germ cells that are histologically graded. Even if we do not have a consensus regarding its therapeutical management, it has a good prognosis, with an excellent overall survival rate and good fertility preservation. More studies are needed regarding the necessity of adjuvant chemotherapy in pediatric oncology, and because of chemotherapy’s long-term adverse effects, surveillance or a targeted treatment is preferred, but the main therapy is fertility-sparing surgery. Special attention should be given to the genetic mapping of the histological pieces for patient risk stratification due to its value in prognosis and future treatment. MDPI 2023-04-23 /pmc/articles/PMC10177811/ /pubmed/37174909 http://dx.doi.org/10.3390/diagnostics13091516 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Moraru, Liviu
Mitranovici, Melinda-Ildiko
Chiorean, Diana Maria
Coroș, Marius
Moraru, Raluca
Oală, Ioan Emilian
Turdean, Sabin Gligore
Immature Teratoma: Diagnosis and Management—A Review of the Literature
title Immature Teratoma: Diagnosis and Management—A Review of the Literature
title_full Immature Teratoma: Diagnosis and Management—A Review of the Literature
title_fullStr Immature Teratoma: Diagnosis and Management—A Review of the Literature
title_full_unstemmed Immature Teratoma: Diagnosis and Management—A Review of the Literature
title_short Immature Teratoma: Diagnosis and Management—A Review of the Literature
title_sort immature teratoma: diagnosis and management—a review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177811/
https://www.ncbi.nlm.nih.gov/pubmed/37174909
http://dx.doi.org/10.3390/diagnostics13091516
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