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Effects of a High-Protein Diet on Kidney Injury under Conditions of Non-CKD or CKD in Mice

Considering the prevalence of obesity and global aging, the consumption of a high-protein diet (HPD) may be advantageous. However, an HPD aggravates kidney dysfunction in patients with chronic kidney disease (CKD). Moreover, the effects of an HPD on kidney function in healthy individuals are controv...

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Autores principales: Tanaka, Shohei, Wakui, Hiromichi, Azushima, Kengo, Tsukamoto, Shunichiro, Yamaji, Takahiro, Urate, Shingo, Suzuki, Toru, Abe, Eriko, Taguchi, Shinya, Yamada, Takayuki, Kobayashi, Ryu, Kanaoka, Tomohiko, Kamimura, Daisuke, Kinguchi, Sho, Takiguchi, Masahito, Funakoshi, Kengo, Yamashita, Akio, Ishigami, Tomoaki, Tamura, Kouichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177820/
https://www.ncbi.nlm.nih.gov/pubmed/37175483
http://dx.doi.org/10.3390/ijms24097778
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author Tanaka, Shohei
Wakui, Hiromichi
Azushima, Kengo
Tsukamoto, Shunichiro
Yamaji, Takahiro
Urate, Shingo
Suzuki, Toru
Abe, Eriko
Taguchi, Shinya
Yamada, Takayuki
Kobayashi, Ryu
Kanaoka, Tomohiko
Kamimura, Daisuke
Kinguchi, Sho
Takiguchi, Masahito
Funakoshi, Kengo
Yamashita, Akio
Ishigami, Tomoaki
Tamura, Kouichi
author_facet Tanaka, Shohei
Wakui, Hiromichi
Azushima, Kengo
Tsukamoto, Shunichiro
Yamaji, Takahiro
Urate, Shingo
Suzuki, Toru
Abe, Eriko
Taguchi, Shinya
Yamada, Takayuki
Kobayashi, Ryu
Kanaoka, Tomohiko
Kamimura, Daisuke
Kinguchi, Sho
Takiguchi, Masahito
Funakoshi, Kengo
Yamashita, Akio
Ishigami, Tomoaki
Tamura, Kouichi
author_sort Tanaka, Shohei
collection PubMed
description Considering the prevalence of obesity and global aging, the consumption of a high-protein diet (HPD) may be advantageous. However, an HPD aggravates kidney dysfunction in patients with chronic kidney disease (CKD). Moreover, the effects of an HPD on kidney function in healthy individuals are controversial. In this study, we employed a remnant kidney mouse model as a CKD model and aimed to evaluate the effects of an HPD on kidney injury under conditions of non-CKD and CKD. Mice were divided into four groups: a sham surgery (sham) + normal diet (ND) group, a sham + HPD group, a 5/6 nephrectomy (Nx) + ND group and a 5/6 Nx + HPD group. Blood pressure, kidney function and kidney tissue injury were compared after 12 weeks of diet loading among the four groups. The 5/6 Nx groups displayed blood pressure elevation, kidney function decline, glomerular injury and tubular injury compared with the sham groups. Furthermore, an HPD exacerbated glomerular injury only in the 5/6 Nx group; however, an HPD did not cause kidney injury in the sham group. Clinical application of these results suggests that patients with CKD should follow a protein-restricted diet to prevent the exacerbation of kidney injury, while healthy individuals can maintain an HPD without worrying about the adverse effects.
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spelling pubmed-101778202023-05-13 Effects of a High-Protein Diet on Kidney Injury under Conditions of Non-CKD or CKD in Mice Tanaka, Shohei Wakui, Hiromichi Azushima, Kengo Tsukamoto, Shunichiro Yamaji, Takahiro Urate, Shingo Suzuki, Toru Abe, Eriko Taguchi, Shinya Yamada, Takayuki Kobayashi, Ryu Kanaoka, Tomohiko Kamimura, Daisuke Kinguchi, Sho Takiguchi, Masahito Funakoshi, Kengo Yamashita, Akio Ishigami, Tomoaki Tamura, Kouichi Int J Mol Sci Article Considering the prevalence of obesity and global aging, the consumption of a high-protein diet (HPD) may be advantageous. However, an HPD aggravates kidney dysfunction in patients with chronic kidney disease (CKD). Moreover, the effects of an HPD on kidney function in healthy individuals are controversial. In this study, we employed a remnant kidney mouse model as a CKD model and aimed to evaluate the effects of an HPD on kidney injury under conditions of non-CKD and CKD. Mice were divided into four groups: a sham surgery (sham) + normal diet (ND) group, a sham + HPD group, a 5/6 nephrectomy (Nx) + ND group and a 5/6 Nx + HPD group. Blood pressure, kidney function and kidney tissue injury were compared after 12 weeks of diet loading among the four groups. The 5/6 Nx groups displayed blood pressure elevation, kidney function decline, glomerular injury and tubular injury compared with the sham groups. Furthermore, an HPD exacerbated glomerular injury only in the 5/6 Nx group; however, an HPD did not cause kidney injury in the sham group. Clinical application of these results suggests that patients with CKD should follow a protein-restricted diet to prevent the exacerbation of kidney injury, while healthy individuals can maintain an HPD without worrying about the adverse effects. MDPI 2023-04-24 /pmc/articles/PMC10177820/ /pubmed/37175483 http://dx.doi.org/10.3390/ijms24097778 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tanaka, Shohei
Wakui, Hiromichi
Azushima, Kengo
Tsukamoto, Shunichiro
Yamaji, Takahiro
Urate, Shingo
Suzuki, Toru
Abe, Eriko
Taguchi, Shinya
Yamada, Takayuki
Kobayashi, Ryu
Kanaoka, Tomohiko
Kamimura, Daisuke
Kinguchi, Sho
Takiguchi, Masahito
Funakoshi, Kengo
Yamashita, Akio
Ishigami, Tomoaki
Tamura, Kouichi
Effects of a High-Protein Diet on Kidney Injury under Conditions of Non-CKD or CKD in Mice
title Effects of a High-Protein Diet on Kidney Injury under Conditions of Non-CKD or CKD in Mice
title_full Effects of a High-Protein Diet on Kidney Injury under Conditions of Non-CKD or CKD in Mice
title_fullStr Effects of a High-Protein Diet on Kidney Injury under Conditions of Non-CKD or CKD in Mice
title_full_unstemmed Effects of a High-Protein Diet on Kidney Injury under Conditions of Non-CKD or CKD in Mice
title_short Effects of a High-Protein Diet on Kidney Injury under Conditions of Non-CKD or CKD in Mice
title_sort effects of a high-protein diet on kidney injury under conditions of non-ckd or ckd in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177820/
https://www.ncbi.nlm.nih.gov/pubmed/37175483
http://dx.doi.org/10.3390/ijms24097778
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