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Effects of a High-Protein Diet on Kidney Injury under Conditions of Non-CKD or CKD in Mice
Considering the prevalence of obesity and global aging, the consumption of a high-protein diet (HPD) may be advantageous. However, an HPD aggravates kidney dysfunction in patients with chronic kidney disease (CKD). Moreover, the effects of an HPD on kidney function in healthy individuals are controv...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177820/ https://www.ncbi.nlm.nih.gov/pubmed/37175483 http://dx.doi.org/10.3390/ijms24097778 |
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author | Tanaka, Shohei Wakui, Hiromichi Azushima, Kengo Tsukamoto, Shunichiro Yamaji, Takahiro Urate, Shingo Suzuki, Toru Abe, Eriko Taguchi, Shinya Yamada, Takayuki Kobayashi, Ryu Kanaoka, Tomohiko Kamimura, Daisuke Kinguchi, Sho Takiguchi, Masahito Funakoshi, Kengo Yamashita, Akio Ishigami, Tomoaki Tamura, Kouichi |
author_facet | Tanaka, Shohei Wakui, Hiromichi Azushima, Kengo Tsukamoto, Shunichiro Yamaji, Takahiro Urate, Shingo Suzuki, Toru Abe, Eriko Taguchi, Shinya Yamada, Takayuki Kobayashi, Ryu Kanaoka, Tomohiko Kamimura, Daisuke Kinguchi, Sho Takiguchi, Masahito Funakoshi, Kengo Yamashita, Akio Ishigami, Tomoaki Tamura, Kouichi |
author_sort | Tanaka, Shohei |
collection | PubMed |
description | Considering the prevalence of obesity and global aging, the consumption of a high-protein diet (HPD) may be advantageous. However, an HPD aggravates kidney dysfunction in patients with chronic kidney disease (CKD). Moreover, the effects of an HPD on kidney function in healthy individuals are controversial. In this study, we employed a remnant kidney mouse model as a CKD model and aimed to evaluate the effects of an HPD on kidney injury under conditions of non-CKD and CKD. Mice were divided into four groups: a sham surgery (sham) + normal diet (ND) group, a sham + HPD group, a 5/6 nephrectomy (Nx) + ND group and a 5/6 Nx + HPD group. Blood pressure, kidney function and kidney tissue injury were compared after 12 weeks of diet loading among the four groups. The 5/6 Nx groups displayed blood pressure elevation, kidney function decline, glomerular injury and tubular injury compared with the sham groups. Furthermore, an HPD exacerbated glomerular injury only in the 5/6 Nx group; however, an HPD did not cause kidney injury in the sham group. Clinical application of these results suggests that patients with CKD should follow a protein-restricted diet to prevent the exacerbation of kidney injury, while healthy individuals can maintain an HPD without worrying about the adverse effects. |
format | Online Article Text |
id | pubmed-10177820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101778202023-05-13 Effects of a High-Protein Diet on Kidney Injury under Conditions of Non-CKD or CKD in Mice Tanaka, Shohei Wakui, Hiromichi Azushima, Kengo Tsukamoto, Shunichiro Yamaji, Takahiro Urate, Shingo Suzuki, Toru Abe, Eriko Taguchi, Shinya Yamada, Takayuki Kobayashi, Ryu Kanaoka, Tomohiko Kamimura, Daisuke Kinguchi, Sho Takiguchi, Masahito Funakoshi, Kengo Yamashita, Akio Ishigami, Tomoaki Tamura, Kouichi Int J Mol Sci Article Considering the prevalence of obesity and global aging, the consumption of a high-protein diet (HPD) may be advantageous. However, an HPD aggravates kidney dysfunction in patients with chronic kidney disease (CKD). Moreover, the effects of an HPD on kidney function in healthy individuals are controversial. In this study, we employed a remnant kidney mouse model as a CKD model and aimed to evaluate the effects of an HPD on kidney injury under conditions of non-CKD and CKD. Mice were divided into four groups: a sham surgery (sham) + normal diet (ND) group, a sham + HPD group, a 5/6 nephrectomy (Nx) + ND group and a 5/6 Nx + HPD group. Blood pressure, kidney function and kidney tissue injury were compared after 12 weeks of diet loading among the four groups. The 5/6 Nx groups displayed blood pressure elevation, kidney function decline, glomerular injury and tubular injury compared with the sham groups. Furthermore, an HPD exacerbated glomerular injury only in the 5/6 Nx group; however, an HPD did not cause kidney injury in the sham group. Clinical application of these results suggests that patients with CKD should follow a protein-restricted diet to prevent the exacerbation of kidney injury, while healthy individuals can maintain an HPD without worrying about the adverse effects. MDPI 2023-04-24 /pmc/articles/PMC10177820/ /pubmed/37175483 http://dx.doi.org/10.3390/ijms24097778 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tanaka, Shohei Wakui, Hiromichi Azushima, Kengo Tsukamoto, Shunichiro Yamaji, Takahiro Urate, Shingo Suzuki, Toru Abe, Eriko Taguchi, Shinya Yamada, Takayuki Kobayashi, Ryu Kanaoka, Tomohiko Kamimura, Daisuke Kinguchi, Sho Takiguchi, Masahito Funakoshi, Kengo Yamashita, Akio Ishigami, Tomoaki Tamura, Kouichi Effects of a High-Protein Diet on Kidney Injury under Conditions of Non-CKD or CKD in Mice |
title | Effects of a High-Protein Diet on Kidney Injury under Conditions of Non-CKD or CKD in Mice |
title_full | Effects of a High-Protein Diet on Kidney Injury under Conditions of Non-CKD or CKD in Mice |
title_fullStr | Effects of a High-Protein Diet on Kidney Injury under Conditions of Non-CKD or CKD in Mice |
title_full_unstemmed | Effects of a High-Protein Diet on Kidney Injury under Conditions of Non-CKD or CKD in Mice |
title_short | Effects of a High-Protein Diet on Kidney Injury under Conditions of Non-CKD or CKD in Mice |
title_sort | effects of a high-protein diet on kidney injury under conditions of non-ckd or ckd in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177820/ https://www.ncbi.nlm.nih.gov/pubmed/37175483 http://dx.doi.org/10.3390/ijms24097778 |
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