AI-Predicted mTOR Inhibitor Reduces Cancer Cell Proliferation and Extends the Lifespan of C. elegans

The mechanistic target of rapamycin (mTOR) kinase is one of the top drug targets for promoting health and lifespan extension. Besides rapamycin, only a few other mTOR inhibitors have been developed and shown to be capable of slowing aging. We used machine learning to predict novel small molecules ta...

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Detalles Bibliográficos
Autores principales: Vidovic, Tinka, Dakhovnik, Alexander, Hrabovskyi, Oleksii, MacArthur, Michael R., Ewald, Collin Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177929/
https://www.ncbi.nlm.nih.gov/pubmed/37175557
http://dx.doi.org/10.3390/ijms24097850

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