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Hypoxic Stress-Dependent Regulation of Na,K-ATPase in Ischemic Heart Disease
In cardiomyocytes, regular activity of the Na,K-ATPase (NKA) and its Na/K pump activity is essential for maintaining ion gradients, excitability, propagation of action potentials, electro-mechanical coupling, trans-membrane Na(+) and Ca(2+) gradients and, thus, contractility. The activity of NKA is...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177966/ https://www.ncbi.nlm.nih.gov/pubmed/37175562 http://dx.doi.org/10.3390/ijms24097855 |
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author | Baloglu, Emel |
author_facet | Baloglu, Emel |
author_sort | Baloglu, Emel |
collection | PubMed |
description | In cardiomyocytes, regular activity of the Na,K-ATPase (NKA) and its Na/K pump activity is essential for maintaining ion gradients, excitability, propagation of action potentials, electro-mechanical coupling, trans-membrane Na(+) and Ca(2+) gradients and, thus, contractility. The activity of NKA is impaired in ischemic heart disease and heart failure, which has been attributed to decreased expression of the NKA subunits. Decreased NKA activity leads to intracellular Na(+) and Ca(2+) overload, diastolic dysfunction and arrhythmias. One signal likely related to these events is hypoxia, where hypoxia-inducible factors (HIF) play a critical role in the adaptation of cells to low oxygen tension. HIF activity increases in ischemic heart, hypertension, heart failure and cardiac fibrosis; thus, it might contribute to the impaired function of NKA. This review will mainly focus on the regulation of NKA in ischemic heart disease in the context of stressed myocardium and the hypoxia–HIF axis and argue on possible consequences of treatment. |
format | Online Article Text |
id | pubmed-10177966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101779662023-05-13 Hypoxic Stress-Dependent Regulation of Na,K-ATPase in Ischemic Heart Disease Baloglu, Emel Int J Mol Sci Review In cardiomyocytes, regular activity of the Na,K-ATPase (NKA) and its Na/K pump activity is essential for maintaining ion gradients, excitability, propagation of action potentials, electro-mechanical coupling, trans-membrane Na(+) and Ca(2+) gradients and, thus, contractility. The activity of NKA is impaired in ischemic heart disease and heart failure, which has been attributed to decreased expression of the NKA subunits. Decreased NKA activity leads to intracellular Na(+) and Ca(2+) overload, diastolic dysfunction and arrhythmias. One signal likely related to these events is hypoxia, where hypoxia-inducible factors (HIF) play a critical role in the adaptation of cells to low oxygen tension. HIF activity increases in ischemic heart, hypertension, heart failure and cardiac fibrosis; thus, it might contribute to the impaired function of NKA. This review will mainly focus on the regulation of NKA in ischemic heart disease in the context of stressed myocardium and the hypoxia–HIF axis and argue on possible consequences of treatment. MDPI 2023-04-26 /pmc/articles/PMC10177966/ /pubmed/37175562 http://dx.doi.org/10.3390/ijms24097855 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Baloglu, Emel Hypoxic Stress-Dependent Regulation of Na,K-ATPase in Ischemic Heart Disease |
title | Hypoxic Stress-Dependent Regulation of Na,K-ATPase in Ischemic Heart Disease |
title_full | Hypoxic Stress-Dependent Regulation of Na,K-ATPase in Ischemic Heart Disease |
title_fullStr | Hypoxic Stress-Dependent Regulation of Na,K-ATPase in Ischemic Heart Disease |
title_full_unstemmed | Hypoxic Stress-Dependent Regulation of Na,K-ATPase in Ischemic Heart Disease |
title_short | Hypoxic Stress-Dependent Regulation of Na,K-ATPase in Ischemic Heart Disease |
title_sort | hypoxic stress-dependent regulation of na,k-atpase in ischemic heart disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177966/ https://www.ncbi.nlm.nih.gov/pubmed/37175562 http://dx.doi.org/10.3390/ijms24097855 |
work_keys_str_mv | AT balogluemel hypoxicstressdependentregulationofnakatpaseinischemicheartdisease |