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Exploring the Genetic Predisposition to Epigenetic Changes in Alzheimer’s Disease
Alzheimer’s disease (AD) is a prevalent type of dementia in elderly populations with a significant genetic component. The accumulating evidence suggests that AD involves a reconfiguration of the epigenetic landscape, including DNA methylation, post-translational modification of histone proteins, and...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177989/ https://www.ncbi.nlm.nih.gov/pubmed/37175659 http://dx.doi.org/10.3390/ijms24097955 |
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author | Bryzgalov, Leonid O. Korbolina, Elena E. Merkulova, Tatiana I. |
author_facet | Bryzgalov, Leonid O. Korbolina, Elena E. Merkulova, Tatiana I. |
author_sort | Bryzgalov, Leonid O. |
collection | PubMed |
description | Alzheimer’s disease (AD) is a prevalent type of dementia in elderly populations with a significant genetic component. The accumulating evidence suggests that AD involves a reconfiguration of the epigenetic landscape, including DNA methylation, post-translational modification of histone proteins, and chromatin remodeling. Along with environmental factors, individual specific genetic features play a considerable role in the formation of epigenetic architecture. In this study, we attempt to identify the non-coding regulatory SNPs (rSNPs) able to affect the epigenetic mechanisms in AD. To this end, the multi-omics approach is used. The GEO (Gene Expression Omnibus) available data (GSE153875) for AD patients and controls are integrated to reveal the rSNPs that display allele-specific features in both ChIP-seq profiles of four histone modifications and RNA-seq. Furthermore, we analyze the presence of rSNPs in the promoters of genes reported to be differentially expressed between AD and the normal brain (AD-related genes) and involved in epigenetic regulation according to the EpiFactors database. We also searched for the rSNPs in the promoters of the genes coding for transcription regulators of the identified AD-related genes. These regulators were selected based on the corresponding ChIP-seq peaks (ENCODE) in the promoter regions of these genes. Finally, we formed a panel of rSNPs localized to the promoters of genes that contribute to the epigenetic landscape in AD and, thus, to the genetic predisposition for this disease. |
format | Online Article Text |
id | pubmed-10177989 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101779892023-05-13 Exploring the Genetic Predisposition to Epigenetic Changes in Alzheimer’s Disease Bryzgalov, Leonid O. Korbolina, Elena E. Merkulova, Tatiana I. Int J Mol Sci Article Alzheimer’s disease (AD) is a prevalent type of dementia in elderly populations with a significant genetic component. The accumulating evidence suggests that AD involves a reconfiguration of the epigenetic landscape, including DNA methylation, post-translational modification of histone proteins, and chromatin remodeling. Along with environmental factors, individual specific genetic features play a considerable role in the formation of epigenetic architecture. In this study, we attempt to identify the non-coding regulatory SNPs (rSNPs) able to affect the epigenetic mechanisms in AD. To this end, the multi-omics approach is used. The GEO (Gene Expression Omnibus) available data (GSE153875) for AD patients and controls are integrated to reveal the rSNPs that display allele-specific features in both ChIP-seq profiles of four histone modifications and RNA-seq. Furthermore, we analyze the presence of rSNPs in the promoters of genes reported to be differentially expressed between AD and the normal brain (AD-related genes) and involved in epigenetic regulation according to the EpiFactors database. We also searched for the rSNPs in the promoters of the genes coding for transcription regulators of the identified AD-related genes. These regulators were selected based on the corresponding ChIP-seq peaks (ENCODE) in the promoter regions of these genes. Finally, we formed a panel of rSNPs localized to the promoters of genes that contribute to the epigenetic landscape in AD and, thus, to the genetic predisposition for this disease. MDPI 2023-04-27 /pmc/articles/PMC10177989/ /pubmed/37175659 http://dx.doi.org/10.3390/ijms24097955 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bryzgalov, Leonid O. Korbolina, Elena E. Merkulova, Tatiana I. Exploring the Genetic Predisposition to Epigenetic Changes in Alzheimer’s Disease |
title | Exploring the Genetic Predisposition to Epigenetic Changes in Alzheimer’s Disease |
title_full | Exploring the Genetic Predisposition to Epigenetic Changes in Alzheimer’s Disease |
title_fullStr | Exploring the Genetic Predisposition to Epigenetic Changes in Alzheimer’s Disease |
title_full_unstemmed | Exploring the Genetic Predisposition to Epigenetic Changes in Alzheimer’s Disease |
title_short | Exploring the Genetic Predisposition to Epigenetic Changes in Alzheimer’s Disease |
title_sort | exploring the genetic predisposition to epigenetic changes in alzheimer’s disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177989/ https://www.ncbi.nlm.nih.gov/pubmed/37175659 http://dx.doi.org/10.3390/ijms24097955 |
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