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Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis
Liver function influences the plasma antithrombin (AT)-III levels. AT-III is beneficial for patients with portal vein thrombosis (PVT) and low plasma AT-III levels. However, whether these levels affect prognosis in patients with cirrhosis-associated PVT remains unknown. This retrospective study invo...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178007/ https://www.ncbi.nlm.nih.gov/pubmed/37175438 http://dx.doi.org/10.3390/ijms24097732 |
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author | Suda, Tsuyoshi Takatori, Hajime Hayashi, Takehiro Kaji, Kiichiro Nio, Kouki Terashima, Takeshi Shimakami, Tetsuro Arai, Kuniaki Yamashita, Tatsuya Mizukoshi, Eishiro Honda, Masao Okumura, Kenichiro Kozaka, Kazuto Yamashita, Taro |
author_facet | Suda, Tsuyoshi Takatori, Hajime Hayashi, Takehiro Kaji, Kiichiro Nio, Kouki Terashima, Takeshi Shimakami, Tetsuro Arai, Kuniaki Yamashita, Tatsuya Mizukoshi, Eishiro Honda, Masao Okumura, Kenichiro Kozaka, Kazuto Yamashita, Taro |
author_sort | Suda, Tsuyoshi |
collection | PubMed |
description | Liver function influences the plasma antithrombin (AT)-III levels. AT-III is beneficial for patients with portal vein thrombosis (PVT) and low plasma AT-III levels. However, whether these levels affect prognosis in patients with cirrhosis-associated PVT remains unknown. This retrospective study involved 75 patients with cirrhosis and PVT treated with danaparoid sodium with or without AT-III. The plasma AT-III level was significantly lower in patients with liver failure-related death than in those with hepatocellular carcinoma (HCC)-related death (p = 0.005), although the Child–Pugh and albumin-bilirubin (ALBI) scores were not significantly different between these two groups. Receiver operating characteristic curve analysis of the plasma AT-III levels showed cutoff values of 54.0% at 5-year survival. Low plasma AT-III levels (<54.0%) were associated with significantly worse prognosis than high levels in both overall survival (p = 0.0013) and survival excluding HCC-related death (p < 0.0001). Low plasma AT-III (<54.0%) was also associated with a significantly worse prognosis among patients with Child–Pugh A/B or ALBI grade 1/2 (p < 0.0001). Multivariate analyses indicated that low plasma AT-III levels (<54.0%) were an independent prognostic factor for poor survival outcome. Low plasma AT-III levels may be associated with mortality, particularly liver failure-related death, independent of liver function. |
format | Online Article Text |
id | pubmed-10178007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101780072023-05-13 Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis Suda, Tsuyoshi Takatori, Hajime Hayashi, Takehiro Kaji, Kiichiro Nio, Kouki Terashima, Takeshi Shimakami, Tetsuro Arai, Kuniaki Yamashita, Tatsuya Mizukoshi, Eishiro Honda, Masao Okumura, Kenichiro Kozaka, Kazuto Yamashita, Taro Int J Mol Sci Article Liver function influences the plasma antithrombin (AT)-III levels. AT-III is beneficial for patients with portal vein thrombosis (PVT) and low plasma AT-III levels. However, whether these levels affect prognosis in patients with cirrhosis-associated PVT remains unknown. This retrospective study involved 75 patients with cirrhosis and PVT treated with danaparoid sodium with or without AT-III. The plasma AT-III level was significantly lower in patients with liver failure-related death than in those with hepatocellular carcinoma (HCC)-related death (p = 0.005), although the Child–Pugh and albumin-bilirubin (ALBI) scores were not significantly different between these two groups. Receiver operating characteristic curve analysis of the plasma AT-III levels showed cutoff values of 54.0% at 5-year survival. Low plasma AT-III levels (<54.0%) were associated with significantly worse prognosis than high levels in both overall survival (p = 0.0013) and survival excluding HCC-related death (p < 0.0001). Low plasma AT-III (<54.0%) was also associated with a significantly worse prognosis among patients with Child–Pugh A/B or ALBI grade 1/2 (p < 0.0001). Multivariate analyses indicated that low plasma AT-III levels (<54.0%) were an independent prognostic factor for poor survival outcome. Low plasma AT-III levels may be associated with mortality, particularly liver failure-related death, independent of liver function. MDPI 2023-04-23 /pmc/articles/PMC10178007/ /pubmed/37175438 http://dx.doi.org/10.3390/ijms24097732 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Suda, Tsuyoshi Takatori, Hajime Hayashi, Takehiro Kaji, Kiichiro Nio, Kouki Terashima, Takeshi Shimakami, Tetsuro Arai, Kuniaki Yamashita, Tatsuya Mizukoshi, Eishiro Honda, Masao Okumura, Kenichiro Kozaka, Kazuto Yamashita, Taro Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis |
title | Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis |
title_full | Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis |
title_fullStr | Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis |
title_full_unstemmed | Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis |
title_short | Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis |
title_sort | plasma antithrombin iii levels can be a prognostic factor in liver cirrhosis patients with portal vein thrombosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178007/ https://www.ncbi.nlm.nih.gov/pubmed/37175438 http://dx.doi.org/10.3390/ijms24097732 |
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