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Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis

Liver function influences the plasma antithrombin (AT)-III levels. AT-III is beneficial for patients with portal vein thrombosis (PVT) and low plasma AT-III levels. However, whether these levels affect prognosis in patients with cirrhosis-associated PVT remains unknown. This retrospective study invo...

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Autores principales: Suda, Tsuyoshi, Takatori, Hajime, Hayashi, Takehiro, Kaji, Kiichiro, Nio, Kouki, Terashima, Takeshi, Shimakami, Tetsuro, Arai, Kuniaki, Yamashita, Tatsuya, Mizukoshi, Eishiro, Honda, Masao, Okumura, Kenichiro, Kozaka, Kazuto, Yamashita, Taro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178007/
https://www.ncbi.nlm.nih.gov/pubmed/37175438
http://dx.doi.org/10.3390/ijms24097732
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author Suda, Tsuyoshi
Takatori, Hajime
Hayashi, Takehiro
Kaji, Kiichiro
Nio, Kouki
Terashima, Takeshi
Shimakami, Tetsuro
Arai, Kuniaki
Yamashita, Tatsuya
Mizukoshi, Eishiro
Honda, Masao
Okumura, Kenichiro
Kozaka, Kazuto
Yamashita, Taro
author_facet Suda, Tsuyoshi
Takatori, Hajime
Hayashi, Takehiro
Kaji, Kiichiro
Nio, Kouki
Terashima, Takeshi
Shimakami, Tetsuro
Arai, Kuniaki
Yamashita, Tatsuya
Mizukoshi, Eishiro
Honda, Masao
Okumura, Kenichiro
Kozaka, Kazuto
Yamashita, Taro
author_sort Suda, Tsuyoshi
collection PubMed
description Liver function influences the plasma antithrombin (AT)-III levels. AT-III is beneficial for patients with portal vein thrombosis (PVT) and low plasma AT-III levels. However, whether these levels affect prognosis in patients with cirrhosis-associated PVT remains unknown. This retrospective study involved 75 patients with cirrhosis and PVT treated with danaparoid sodium with or without AT-III. The plasma AT-III level was significantly lower in patients with liver failure-related death than in those with hepatocellular carcinoma (HCC)-related death (p = 0.005), although the Child–Pugh and albumin-bilirubin (ALBI) scores were not significantly different between these two groups. Receiver operating characteristic curve analysis of the plasma AT-III levels showed cutoff values of 54.0% at 5-year survival. Low plasma AT-III levels (<54.0%) were associated with significantly worse prognosis than high levels in both overall survival (p = 0.0013) and survival excluding HCC-related death (p < 0.0001). Low plasma AT-III (<54.0%) was also associated with a significantly worse prognosis among patients with Child–Pugh A/B or ALBI grade 1/2 (p < 0.0001). Multivariate analyses indicated that low plasma AT-III levels (<54.0%) were an independent prognostic factor for poor survival outcome. Low plasma AT-III levels may be associated with mortality, particularly liver failure-related death, independent of liver function.
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spelling pubmed-101780072023-05-13 Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis Suda, Tsuyoshi Takatori, Hajime Hayashi, Takehiro Kaji, Kiichiro Nio, Kouki Terashima, Takeshi Shimakami, Tetsuro Arai, Kuniaki Yamashita, Tatsuya Mizukoshi, Eishiro Honda, Masao Okumura, Kenichiro Kozaka, Kazuto Yamashita, Taro Int J Mol Sci Article Liver function influences the plasma antithrombin (AT)-III levels. AT-III is beneficial for patients with portal vein thrombosis (PVT) and low plasma AT-III levels. However, whether these levels affect prognosis in patients with cirrhosis-associated PVT remains unknown. This retrospective study involved 75 patients with cirrhosis and PVT treated with danaparoid sodium with or without AT-III. The plasma AT-III level was significantly lower in patients with liver failure-related death than in those with hepatocellular carcinoma (HCC)-related death (p = 0.005), although the Child–Pugh and albumin-bilirubin (ALBI) scores were not significantly different between these two groups. Receiver operating characteristic curve analysis of the plasma AT-III levels showed cutoff values of 54.0% at 5-year survival. Low plasma AT-III levels (<54.0%) were associated with significantly worse prognosis than high levels in both overall survival (p = 0.0013) and survival excluding HCC-related death (p < 0.0001). Low plasma AT-III (<54.0%) was also associated with a significantly worse prognosis among patients with Child–Pugh A/B or ALBI grade 1/2 (p < 0.0001). Multivariate analyses indicated that low plasma AT-III levels (<54.0%) were an independent prognostic factor for poor survival outcome. Low plasma AT-III levels may be associated with mortality, particularly liver failure-related death, independent of liver function. MDPI 2023-04-23 /pmc/articles/PMC10178007/ /pubmed/37175438 http://dx.doi.org/10.3390/ijms24097732 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Suda, Tsuyoshi
Takatori, Hajime
Hayashi, Takehiro
Kaji, Kiichiro
Nio, Kouki
Terashima, Takeshi
Shimakami, Tetsuro
Arai, Kuniaki
Yamashita, Tatsuya
Mizukoshi, Eishiro
Honda, Masao
Okumura, Kenichiro
Kozaka, Kazuto
Yamashita, Taro
Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis
title Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis
title_full Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis
title_fullStr Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis
title_full_unstemmed Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis
title_short Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis
title_sort plasma antithrombin iii levels can be a prognostic factor in liver cirrhosis patients with portal vein thrombosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178007/
https://www.ncbi.nlm.nih.gov/pubmed/37175438
http://dx.doi.org/10.3390/ijms24097732
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