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Papillomavirus Infection as Potential Cause of Miscarriage in the Early Gestational Age: A Prospective Study

The possible association between human papillomavirus (HPV) infection and negative pregnancy outcomes has been debated in the literature, with conflicting results from clinical trials. While some authors support a link between HPV and miscarriage, others argue that the mere detection of the virus do...

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Autores principales: Bruno, Maria Teresa, Caruso, Salvatore, Scalia, Guido, Costanzo, Maria, Di Pasqua, Salvatore, Boemi, Sara, Panella, Marco Marzio, Palumbo, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178196/
https://www.ncbi.nlm.nih.gov/pubmed/37175050
http://dx.doi.org/10.3390/diagnostics13091659
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author Bruno, Maria Teresa
Caruso, Salvatore
Scalia, Guido
Costanzo, Maria
Di Pasqua, Salvatore
Boemi, Sara
Panella, Marco Marzio
Palumbo, Marco
author_facet Bruno, Maria Teresa
Caruso, Salvatore
Scalia, Guido
Costanzo, Maria
Di Pasqua, Salvatore
Boemi, Sara
Panella, Marco Marzio
Palumbo, Marco
author_sort Bruno, Maria Teresa
collection PubMed
description The possible association between human papillomavirus (HPV) infection and negative pregnancy outcomes has been debated in the literature, with conflicting results from clinical trials. While some authors support a link between HPV and miscarriage, others argue that the mere detection of the virus does not necessarily indicate a causal relationship with negative pregnancy outcomes. In this study, we conducted a prospective, controlled investigation of the potential association between HPV infection and miscarriage. Our study included 59 women who had experienced a miscarriage and 57 women who had undergone voluntary termination of pregnancy (TOP) within the 12th week of gestation. We assessed HPV prevalence, maternal age, and HPV genotype in both groups and evaluated the relationship between these factors and pregnancy outcome. Unlike previous studies that only identified HPV in cases of abortion, we also correlated the positivity of chorionic villi with gestational age in both groups. We found a close correlation between positive chorionic villi and very early gestational age, with all 13 cases of virus-positive chorionic villi in the miscarriage group occurring in gestational periods of less than 8 + 5 weeks (<60 days) (RR = 28.6). Our analysis showed no correlation between HPV infection and maternal age or viral genotypes. The results suggest that the presence of HPV alone is not enough to cause spontaneous abortion, but a high viral load in early pregnancy may increase the risk of negative outcomes. These findings have important implications for the management of HPV infection during pregnancy and may provide a rationale for the use of HPV vaccines to reduce the incidence of spontaneous abortion and infertility due to preclinical spontaneous abortions.
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spelling pubmed-101781962023-05-13 Papillomavirus Infection as Potential Cause of Miscarriage in the Early Gestational Age: A Prospective Study Bruno, Maria Teresa Caruso, Salvatore Scalia, Guido Costanzo, Maria Di Pasqua, Salvatore Boemi, Sara Panella, Marco Marzio Palumbo, Marco Diagnostics (Basel) Article The possible association between human papillomavirus (HPV) infection and negative pregnancy outcomes has been debated in the literature, with conflicting results from clinical trials. While some authors support a link between HPV and miscarriage, others argue that the mere detection of the virus does not necessarily indicate a causal relationship with negative pregnancy outcomes. In this study, we conducted a prospective, controlled investigation of the potential association between HPV infection and miscarriage. Our study included 59 women who had experienced a miscarriage and 57 women who had undergone voluntary termination of pregnancy (TOP) within the 12th week of gestation. We assessed HPV prevalence, maternal age, and HPV genotype in both groups and evaluated the relationship between these factors and pregnancy outcome. Unlike previous studies that only identified HPV in cases of abortion, we also correlated the positivity of chorionic villi with gestational age in both groups. We found a close correlation between positive chorionic villi and very early gestational age, with all 13 cases of virus-positive chorionic villi in the miscarriage group occurring in gestational periods of less than 8 + 5 weeks (<60 days) (RR = 28.6). Our analysis showed no correlation between HPV infection and maternal age or viral genotypes. The results suggest that the presence of HPV alone is not enough to cause spontaneous abortion, but a high viral load in early pregnancy may increase the risk of negative outcomes. These findings have important implications for the management of HPV infection during pregnancy and may provide a rationale for the use of HPV vaccines to reduce the incidence of spontaneous abortion and infertility due to preclinical spontaneous abortions. MDPI 2023-05-08 /pmc/articles/PMC10178196/ /pubmed/37175050 http://dx.doi.org/10.3390/diagnostics13091659 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bruno, Maria Teresa
Caruso, Salvatore
Scalia, Guido
Costanzo, Maria
Di Pasqua, Salvatore
Boemi, Sara
Panella, Marco Marzio
Palumbo, Marco
Papillomavirus Infection as Potential Cause of Miscarriage in the Early Gestational Age: A Prospective Study
title Papillomavirus Infection as Potential Cause of Miscarriage in the Early Gestational Age: A Prospective Study
title_full Papillomavirus Infection as Potential Cause of Miscarriage in the Early Gestational Age: A Prospective Study
title_fullStr Papillomavirus Infection as Potential Cause of Miscarriage in the Early Gestational Age: A Prospective Study
title_full_unstemmed Papillomavirus Infection as Potential Cause of Miscarriage in the Early Gestational Age: A Prospective Study
title_short Papillomavirus Infection as Potential Cause of Miscarriage in the Early Gestational Age: A Prospective Study
title_sort papillomavirus infection as potential cause of miscarriage in the early gestational age: a prospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178196/
https://www.ncbi.nlm.nih.gov/pubmed/37175050
http://dx.doi.org/10.3390/diagnostics13091659
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