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Improving the Modeling of Extracellular Ligand Binding Pockets in RosettaGPCR for Conformational Selection
G protein-coupled receptors (GPCRs) are the largest class of drug targets and undergo substantial conformational changes in response to ligand binding. Despite recent progress in GPCR structure determination, static snapshots fail to reflect the conformational space of putative binding pocket geomet...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178219/ https://www.ncbi.nlm.nih.gov/pubmed/37175495 http://dx.doi.org/10.3390/ijms24097788 |