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Investigation of the Changes in Concentrations of Vitamin D-Binding Protein and Lactoferin in Plasma and Peritoneal Fluid of Patients with Endometriosis

An evaluation of the association between the concentrations of vitamin D-binding protein and lactoferrin in the plasma and peritoneal fluid may facilitate the elucidation of molecular mechanisms in endometriosis. Vitamin D-binding protein and lactoferrin concentrations were measured by ELISA in plas...

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Detalles Bibliográficos
Autores principales: Lisowska-Myjak, Barbara, Skarżyńska, Ewa, Wróbel, Monika, Mańka, Grzegorz, Kiecka, Mariusz, Lipa, Michał, Warzecha, Damian, Spaczyński, Robert, Piekarski, Piotr, Banaszewska, Beata, Jakimiuk, Artur, Issat, Tadeusz, Rokita, Wojciech, Młodawski, Jakub, Szubert, Maria, Sieroszewski, Piotr, Raba, Grzegorz, Szczupak, Kamil, Kluz, Tomasz, Kluza, Marek, Wielgoś, Mirosław, Laudański, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178223/
https://www.ncbi.nlm.nih.gov/pubmed/37175534
http://dx.doi.org/10.3390/ijms24097828
Descripción
Sumario:An evaluation of the association between the concentrations of vitamin D-binding protein and lactoferrin in the plasma and peritoneal fluid may facilitate the elucidation of molecular mechanisms in endometriosis. Vitamin D-binding protein and lactoferrin concentrations were measured by ELISA in plasma and peritoneal fluid samples from 95 women with suspected endometriosis as classified by laparoscopy into groups with (n = 59) and without endometriosis (n = 36). There were no differences (p > 0.05) in the plasma and peritoneal fluid concentrations of vitamin D-binding protein and lactoferrin between women with and without endometriosis. In women with endometriosis, there was a significant correlation between plasma and peritoneal fluid vitamin D-binding protein concentrations (r = 0.821; p = 0.000), but there was no correlation between lactoferrin concentrations in those compartments (r = 0.049; p > 0.05). Furthermore, in endometriosis, lactoferrin was found to correlate poorly with vitamin D-binding protein (r= −0.236; p > 0.05) in plasma, while in the peritoneal fluid, the correlation between those proteins was significant (r = 0.399; p = 0.002). The characteristic properties of vitamin D-binding protein and lactoferrin and the associations between their plasma and peritoneal fluid concentrations found in women with endometriosis may provide a novel panel of markers to identify high-risk patients in need of further diagnostic measures.