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Microembolizations in the Arterial Cerebral Circulation in Patients with Atrial Fibrillation Ablation Using the Cryoballoon Technique—Protocol and Methodology of a Prospective Observational Study
There is considerable uncertainty regarding the impact of microembolic signals (MESs) on neuropsychological abilities in patients receiving pulmonary vein isolation and beyond using the cryoballoon technique. We conducted the largest prospective observational study on this topic, providing insights...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178285/ https://www.ncbi.nlm.nih.gov/pubmed/37175051 http://dx.doi.org/10.3390/diagnostics13091660 |
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author | Erkapic, Damir Aleksic, Marko Roussopoulos, Konstantinos Weipert, Kay Felix Sözener, Korkut Kostev, Karel Allendörfer, Jens Rosenbauer, Josef Guenduez, Dursun Tanislav, Christian |
author_facet | Erkapic, Damir Aleksic, Marko Roussopoulos, Konstantinos Weipert, Kay Felix Sözener, Korkut Kostev, Karel Allendörfer, Jens Rosenbauer, Josef Guenduez, Dursun Tanislav, Christian |
author_sort | Erkapic, Damir |
collection | PubMed |
description | There is considerable uncertainty regarding the impact of microembolic signals (MESs) on neuropsychological abilities in patients receiving pulmonary vein isolation and beyond using the cryoballoon technique. We conducted the largest prospective observational study on this topic, providing insights into the gradual unmasking of procedure-related MESs and their impacts on neuropsychological outcomes. MESs were continuously detected periprocedurally using transcranial Doppler ultrasonography. Neuropsychological status was evaluated comprehensively using the CERAD Plus test battery, which consists of 11 neuropsychological subtests. Patients with atrial fibrillation were included in the study with an equal distribution (50:50) of paroxysmal or persistent presentations. Of 167 consecutive eligible patients, 100 were included within the study enrollment period from February 2021 to August 2022. The study, including the documentation of all follow-up visits, ended in November 2022. This paper focuses on describing the study protocol and methodology and presenting the baseline data. |
format | Online Article Text |
id | pubmed-10178285 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101782852023-05-13 Microembolizations in the Arterial Cerebral Circulation in Patients with Atrial Fibrillation Ablation Using the Cryoballoon Technique—Protocol and Methodology of a Prospective Observational Study Erkapic, Damir Aleksic, Marko Roussopoulos, Konstantinos Weipert, Kay Felix Sözener, Korkut Kostev, Karel Allendörfer, Jens Rosenbauer, Josef Guenduez, Dursun Tanislav, Christian Diagnostics (Basel) Article There is considerable uncertainty regarding the impact of microembolic signals (MESs) on neuropsychological abilities in patients receiving pulmonary vein isolation and beyond using the cryoballoon technique. We conducted the largest prospective observational study on this topic, providing insights into the gradual unmasking of procedure-related MESs and their impacts on neuropsychological outcomes. MESs were continuously detected periprocedurally using transcranial Doppler ultrasonography. Neuropsychological status was evaluated comprehensively using the CERAD Plus test battery, which consists of 11 neuropsychological subtests. Patients with atrial fibrillation were included in the study with an equal distribution (50:50) of paroxysmal or persistent presentations. Of 167 consecutive eligible patients, 100 were included within the study enrollment period from February 2021 to August 2022. The study, including the documentation of all follow-up visits, ended in November 2022. This paper focuses on describing the study protocol and methodology and presenting the baseline data. MDPI 2023-05-08 /pmc/articles/PMC10178285/ /pubmed/37175051 http://dx.doi.org/10.3390/diagnostics13091660 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Erkapic, Damir Aleksic, Marko Roussopoulos, Konstantinos Weipert, Kay Felix Sözener, Korkut Kostev, Karel Allendörfer, Jens Rosenbauer, Josef Guenduez, Dursun Tanislav, Christian Microembolizations in the Arterial Cerebral Circulation in Patients with Atrial Fibrillation Ablation Using the Cryoballoon Technique—Protocol and Methodology of a Prospective Observational Study |
title | Microembolizations in the Arterial Cerebral Circulation in Patients with Atrial Fibrillation Ablation Using the Cryoballoon Technique—Protocol and Methodology of a Prospective Observational Study |
title_full | Microembolizations in the Arterial Cerebral Circulation in Patients with Atrial Fibrillation Ablation Using the Cryoballoon Technique—Protocol and Methodology of a Prospective Observational Study |
title_fullStr | Microembolizations in the Arterial Cerebral Circulation in Patients with Atrial Fibrillation Ablation Using the Cryoballoon Technique—Protocol and Methodology of a Prospective Observational Study |
title_full_unstemmed | Microembolizations in the Arterial Cerebral Circulation in Patients with Atrial Fibrillation Ablation Using the Cryoballoon Technique—Protocol and Methodology of a Prospective Observational Study |
title_short | Microembolizations in the Arterial Cerebral Circulation in Patients with Atrial Fibrillation Ablation Using the Cryoballoon Technique—Protocol and Methodology of a Prospective Observational Study |
title_sort | microembolizations in the arterial cerebral circulation in patients with atrial fibrillation ablation using the cryoballoon technique—protocol and methodology of a prospective observational study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178285/ https://www.ncbi.nlm.nih.gov/pubmed/37175051 http://dx.doi.org/10.3390/diagnostics13091660 |
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