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Microembolizations in the Arterial Cerebral Circulation in Patients with Atrial Fibrillation Ablation Using the Cryoballoon Technique—Protocol and Methodology of a Prospective Observational Study

There is considerable uncertainty regarding the impact of microembolic signals (MESs) on neuropsychological abilities in patients receiving pulmonary vein isolation and beyond using the cryoballoon technique. We conducted the largest prospective observational study on this topic, providing insights...

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Autores principales: Erkapic, Damir, Aleksic, Marko, Roussopoulos, Konstantinos, Weipert, Kay Felix, Sözener, Korkut, Kostev, Karel, Allendörfer, Jens, Rosenbauer, Josef, Guenduez, Dursun, Tanislav, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178285/
https://www.ncbi.nlm.nih.gov/pubmed/37175051
http://dx.doi.org/10.3390/diagnostics13091660
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author Erkapic, Damir
Aleksic, Marko
Roussopoulos, Konstantinos
Weipert, Kay Felix
Sözener, Korkut
Kostev, Karel
Allendörfer, Jens
Rosenbauer, Josef
Guenduez, Dursun
Tanislav, Christian
author_facet Erkapic, Damir
Aleksic, Marko
Roussopoulos, Konstantinos
Weipert, Kay Felix
Sözener, Korkut
Kostev, Karel
Allendörfer, Jens
Rosenbauer, Josef
Guenduez, Dursun
Tanislav, Christian
author_sort Erkapic, Damir
collection PubMed
description There is considerable uncertainty regarding the impact of microembolic signals (MESs) on neuropsychological abilities in patients receiving pulmonary vein isolation and beyond using the cryoballoon technique. We conducted the largest prospective observational study on this topic, providing insights into the gradual unmasking of procedure-related MESs and their impacts on neuropsychological outcomes. MESs were continuously detected periprocedurally using transcranial Doppler ultrasonography. Neuropsychological status was evaluated comprehensively using the CERAD Plus test battery, which consists of 11 neuropsychological subtests. Patients with atrial fibrillation were included in the study with an equal distribution (50:50) of paroxysmal or persistent presentations. Of 167 consecutive eligible patients, 100 were included within the study enrollment period from February 2021 to August 2022. The study, including the documentation of all follow-up visits, ended in November 2022. This paper focuses on describing the study protocol and methodology and presenting the baseline data.
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spelling pubmed-101782852023-05-13 Microembolizations in the Arterial Cerebral Circulation in Patients with Atrial Fibrillation Ablation Using the Cryoballoon Technique—Protocol and Methodology of a Prospective Observational Study Erkapic, Damir Aleksic, Marko Roussopoulos, Konstantinos Weipert, Kay Felix Sözener, Korkut Kostev, Karel Allendörfer, Jens Rosenbauer, Josef Guenduez, Dursun Tanislav, Christian Diagnostics (Basel) Article There is considerable uncertainty regarding the impact of microembolic signals (MESs) on neuropsychological abilities in patients receiving pulmonary vein isolation and beyond using the cryoballoon technique. We conducted the largest prospective observational study on this topic, providing insights into the gradual unmasking of procedure-related MESs and their impacts on neuropsychological outcomes. MESs were continuously detected periprocedurally using transcranial Doppler ultrasonography. Neuropsychological status was evaluated comprehensively using the CERAD Plus test battery, which consists of 11 neuropsychological subtests. Patients with atrial fibrillation were included in the study with an equal distribution (50:50) of paroxysmal or persistent presentations. Of 167 consecutive eligible patients, 100 were included within the study enrollment period from February 2021 to August 2022. The study, including the documentation of all follow-up visits, ended in November 2022. This paper focuses on describing the study protocol and methodology and presenting the baseline data. MDPI 2023-05-08 /pmc/articles/PMC10178285/ /pubmed/37175051 http://dx.doi.org/10.3390/diagnostics13091660 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Erkapic, Damir
Aleksic, Marko
Roussopoulos, Konstantinos
Weipert, Kay Felix
Sözener, Korkut
Kostev, Karel
Allendörfer, Jens
Rosenbauer, Josef
Guenduez, Dursun
Tanislav, Christian
Microembolizations in the Arterial Cerebral Circulation in Patients with Atrial Fibrillation Ablation Using the Cryoballoon Technique—Protocol and Methodology of a Prospective Observational Study
title Microembolizations in the Arterial Cerebral Circulation in Patients with Atrial Fibrillation Ablation Using the Cryoballoon Technique—Protocol and Methodology of a Prospective Observational Study
title_full Microembolizations in the Arterial Cerebral Circulation in Patients with Atrial Fibrillation Ablation Using the Cryoballoon Technique—Protocol and Methodology of a Prospective Observational Study
title_fullStr Microembolizations in the Arterial Cerebral Circulation in Patients with Atrial Fibrillation Ablation Using the Cryoballoon Technique—Protocol and Methodology of a Prospective Observational Study
title_full_unstemmed Microembolizations in the Arterial Cerebral Circulation in Patients with Atrial Fibrillation Ablation Using the Cryoballoon Technique—Protocol and Methodology of a Prospective Observational Study
title_short Microembolizations in the Arterial Cerebral Circulation in Patients with Atrial Fibrillation Ablation Using the Cryoballoon Technique—Protocol and Methodology of a Prospective Observational Study
title_sort microembolizations in the arterial cerebral circulation in patients with atrial fibrillation ablation using the cryoballoon technique—protocol and methodology of a prospective observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178285/
https://www.ncbi.nlm.nih.gov/pubmed/37175051
http://dx.doi.org/10.3390/diagnostics13091660
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