Cargando…

Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis

The etiology of endometriosis (EMS) has not been clearly elucidated yet, and that is probably the reason why its diagnostic process is frequently long-lasting and inefficient. Nowadays, the non-invasive diagnostic methods of EMS are still being sought. Our study aimed to assess the serum and periton...

Descripción completa

Detalles Bibliográficos
Autores principales: Abramiuk, Monika, Frankowska, Karolina, Kułak, Krzysztof, Tarkowski, Rafał, Mertowska, Paulina, Mertowski, Sebastian, Grywalska, Ewelina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178394/
https://www.ncbi.nlm.nih.gov/pubmed/37175494
http://dx.doi.org/10.3390/ijms24097787
_version_ 1785040851427131392
author Abramiuk, Monika
Frankowska, Karolina
Kułak, Krzysztof
Tarkowski, Rafał
Mertowska, Paulina
Mertowski, Sebastian
Grywalska, Ewelina
author_facet Abramiuk, Monika
Frankowska, Karolina
Kułak, Krzysztof
Tarkowski, Rafał
Mertowska, Paulina
Mertowski, Sebastian
Grywalska, Ewelina
author_sort Abramiuk, Monika
collection PubMed
description The etiology of endometriosis (EMS) has not been clearly elucidated yet, and that is probably the reason why its diagnostic process is frequently long-lasting and inefficient. Nowadays, the non-invasive diagnostic methods of EMS are still being sought. Our study aimed to assess the serum and peritoneal fluid levels of urocortin 1 (Ucn1) in patients with EMS and healthy women. Moreover, considering the immune background of the disease, the association between Ucn1 and several immune parameters was studied in both groups. We found that the serum Ucn1 level was significantly upregulated in women with EMS compared to healthy patients. Moreover, higher serum Ucn1 levels tended to correspond with more advanced stages of the disease (p = 0.031). Receiver operating characteristic (ROC) analysis revealed that based on serum Ucn1 levels, it is possible to distinguish deep infiltrating endometriosis (DIE) from among other EMS types. Together, these results indicate Ucn1 as a possible promising biomarker of EMS: however, not in isolation, but rather to enhance the effectiveness of other diagnostic methods.
format Online
Article
Text
id pubmed-10178394
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-101783942023-05-13 Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis Abramiuk, Monika Frankowska, Karolina Kułak, Krzysztof Tarkowski, Rafał Mertowska, Paulina Mertowski, Sebastian Grywalska, Ewelina Int J Mol Sci Article The etiology of endometriosis (EMS) has not been clearly elucidated yet, and that is probably the reason why its diagnostic process is frequently long-lasting and inefficient. Nowadays, the non-invasive diagnostic methods of EMS are still being sought. Our study aimed to assess the serum and peritoneal fluid levels of urocortin 1 (Ucn1) in patients with EMS and healthy women. Moreover, considering the immune background of the disease, the association between Ucn1 and several immune parameters was studied in both groups. We found that the serum Ucn1 level was significantly upregulated in women with EMS compared to healthy patients. Moreover, higher serum Ucn1 levels tended to correspond with more advanced stages of the disease (p = 0.031). Receiver operating characteristic (ROC) analysis revealed that based on serum Ucn1 levels, it is possible to distinguish deep infiltrating endometriosis (DIE) from among other EMS types. Together, these results indicate Ucn1 as a possible promising biomarker of EMS: however, not in isolation, but rather to enhance the effectiveness of other diagnostic methods. MDPI 2023-04-24 /pmc/articles/PMC10178394/ /pubmed/37175494 http://dx.doi.org/10.3390/ijms24097787 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Abramiuk, Monika
Frankowska, Karolina
Kułak, Krzysztof
Tarkowski, Rafał
Mertowska, Paulina
Mertowski, Sebastian
Grywalska, Ewelina
Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis
title Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis
title_full Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis
title_fullStr Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis
title_full_unstemmed Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis
title_short Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis
title_sort possible correlation between urocortin 1 (ucn1) and immune parameters in patients with endometriosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178394/
https://www.ncbi.nlm.nih.gov/pubmed/37175494
http://dx.doi.org/10.3390/ijms24097787
work_keys_str_mv AT abramiukmonika possiblecorrelationbetweenurocortin1ucn1andimmuneparametersinpatientswithendometriosis
AT frankowskakarolina possiblecorrelationbetweenurocortin1ucn1andimmuneparametersinpatientswithendometriosis
AT kułakkrzysztof possiblecorrelationbetweenurocortin1ucn1andimmuneparametersinpatientswithendometriosis
AT tarkowskirafał possiblecorrelationbetweenurocortin1ucn1andimmuneparametersinpatientswithendometriosis
AT mertowskapaulina possiblecorrelationbetweenurocortin1ucn1andimmuneparametersinpatientswithendometriosis
AT mertowskisebastian possiblecorrelationbetweenurocortin1ucn1andimmuneparametersinpatientswithendometriosis
AT grywalskaewelina possiblecorrelationbetweenurocortin1ucn1andimmuneparametersinpatientswithendometriosis