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Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis
The etiology of endometriosis (EMS) has not been clearly elucidated yet, and that is probably the reason why its diagnostic process is frequently long-lasting and inefficient. Nowadays, the non-invasive diagnostic methods of EMS are still being sought. Our study aimed to assess the serum and periton...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178394/ https://www.ncbi.nlm.nih.gov/pubmed/37175494 http://dx.doi.org/10.3390/ijms24097787 |
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author | Abramiuk, Monika Frankowska, Karolina Kułak, Krzysztof Tarkowski, Rafał Mertowska, Paulina Mertowski, Sebastian Grywalska, Ewelina |
author_facet | Abramiuk, Monika Frankowska, Karolina Kułak, Krzysztof Tarkowski, Rafał Mertowska, Paulina Mertowski, Sebastian Grywalska, Ewelina |
author_sort | Abramiuk, Monika |
collection | PubMed |
description | The etiology of endometriosis (EMS) has not been clearly elucidated yet, and that is probably the reason why its diagnostic process is frequently long-lasting and inefficient. Nowadays, the non-invasive diagnostic methods of EMS are still being sought. Our study aimed to assess the serum and peritoneal fluid levels of urocortin 1 (Ucn1) in patients with EMS and healthy women. Moreover, considering the immune background of the disease, the association between Ucn1 and several immune parameters was studied in both groups. We found that the serum Ucn1 level was significantly upregulated in women with EMS compared to healthy patients. Moreover, higher serum Ucn1 levels tended to correspond with more advanced stages of the disease (p = 0.031). Receiver operating characteristic (ROC) analysis revealed that based on serum Ucn1 levels, it is possible to distinguish deep infiltrating endometriosis (DIE) from among other EMS types. Together, these results indicate Ucn1 as a possible promising biomarker of EMS: however, not in isolation, but rather to enhance the effectiveness of other diagnostic methods. |
format | Online Article Text |
id | pubmed-10178394 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101783942023-05-13 Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis Abramiuk, Monika Frankowska, Karolina Kułak, Krzysztof Tarkowski, Rafał Mertowska, Paulina Mertowski, Sebastian Grywalska, Ewelina Int J Mol Sci Article The etiology of endometriosis (EMS) has not been clearly elucidated yet, and that is probably the reason why its diagnostic process is frequently long-lasting and inefficient. Nowadays, the non-invasive diagnostic methods of EMS are still being sought. Our study aimed to assess the serum and peritoneal fluid levels of urocortin 1 (Ucn1) in patients with EMS and healthy women. Moreover, considering the immune background of the disease, the association between Ucn1 and several immune parameters was studied in both groups. We found that the serum Ucn1 level was significantly upregulated in women with EMS compared to healthy patients. Moreover, higher serum Ucn1 levels tended to correspond with more advanced stages of the disease (p = 0.031). Receiver operating characteristic (ROC) analysis revealed that based on serum Ucn1 levels, it is possible to distinguish deep infiltrating endometriosis (DIE) from among other EMS types. Together, these results indicate Ucn1 as a possible promising biomarker of EMS: however, not in isolation, but rather to enhance the effectiveness of other diagnostic methods. MDPI 2023-04-24 /pmc/articles/PMC10178394/ /pubmed/37175494 http://dx.doi.org/10.3390/ijms24097787 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Abramiuk, Monika Frankowska, Karolina Kułak, Krzysztof Tarkowski, Rafał Mertowska, Paulina Mertowski, Sebastian Grywalska, Ewelina Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis |
title | Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis |
title_full | Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis |
title_fullStr | Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis |
title_full_unstemmed | Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis |
title_short | Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis |
title_sort | possible correlation between urocortin 1 (ucn1) and immune parameters in patients with endometriosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178394/ https://www.ncbi.nlm.nih.gov/pubmed/37175494 http://dx.doi.org/10.3390/ijms24097787 |
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