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Lipid Keratopathy: Histopathology, Major Differential Diagnoses and The Importance of Clinical Correlation

Lipid keratopathy (LK) is a rare ophthalmological condition characterized by a progressive reduction in visual acuity caused by corneal opacification due to central lipid accumulation. LK is characterized by lipid deposits, cholesterol clefts, and neovascularization (NV) leading to disruption in cor...

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Autores principales: Knez, Nora, Walkenhorst, Molly, Haeri, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178412/
https://www.ncbi.nlm.nih.gov/pubmed/37175019
http://dx.doi.org/10.3390/diagnostics13091628
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author Knez, Nora
Walkenhorst, Molly
Haeri, Mohammad
author_facet Knez, Nora
Walkenhorst, Molly
Haeri, Mohammad
author_sort Knez, Nora
collection PubMed
description Lipid keratopathy (LK) is a rare ophthalmological condition characterized by a progressive reduction in visual acuity caused by corneal opacification due to central lipid accumulation. LK is characterized by lipid deposits, cholesterol clefts, and neovascularization (NV) leading to disruption in corneal optical quality. LK classification includes a primary and secondary form which depend on pre-existing corneal or systemic disorders and the evidence of NV. Secondary LK is typically associated with a prior occurrence of herpetic infection, such as herpes zoster keratitis. Patients with LK usually present with progressive vision loss and dense cream-colored corneal opacification. Treatment modalities include conservative and surgical approaches focused on corneal NV elimination. When evaluating corneal lipidosis, it is crucial to consider a range of differential diagnoses, including corneal arcus, Schnyder corneal dystrophy, and other corneal deposit conditions. We report a case of a 62-year-old male with herpes zoster keratitis complicated with LK. He presented with painless progressive vision loss and corneal scarring, which raised suspicion about LK diagnosis. This paper emphasizes the importance of correlating clinical and histological findings for accurate LK diagnosis.
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spelling pubmed-101784122023-05-13 Lipid Keratopathy: Histopathology, Major Differential Diagnoses and The Importance of Clinical Correlation Knez, Nora Walkenhorst, Molly Haeri, Mohammad Diagnostics (Basel) Interesting Images Lipid keratopathy (LK) is a rare ophthalmological condition characterized by a progressive reduction in visual acuity caused by corneal opacification due to central lipid accumulation. LK is characterized by lipid deposits, cholesterol clefts, and neovascularization (NV) leading to disruption in corneal optical quality. LK classification includes a primary and secondary form which depend on pre-existing corneal or systemic disorders and the evidence of NV. Secondary LK is typically associated with a prior occurrence of herpetic infection, such as herpes zoster keratitis. Patients with LK usually present with progressive vision loss and dense cream-colored corneal opacification. Treatment modalities include conservative and surgical approaches focused on corneal NV elimination. When evaluating corneal lipidosis, it is crucial to consider a range of differential diagnoses, including corneal arcus, Schnyder corneal dystrophy, and other corneal deposit conditions. We report a case of a 62-year-old male with herpes zoster keratitis complicated with LK. He presented with painless progressive vision loss and corneal scarring, which raised suspicion about LK diagnosis. This paper emphasizes the importance of correlating clinical and histological findings for accurate LK diagnosis. MDPI 2023-05-04 /pmc/articles/PMC10178412/ /pubmed/37175019 http://dx.doi.org/10.3390/diagnostics13091628 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Interesting Images
Knez, Nora
Walkenhorst, Molly
Haeri, Mohammad
Lipid Keratopathy: Histopathology, Major Differential Diagnoses and The Importance of Clinical Correlation
title Lipid Keratopathy: Histopathology, Major Differential Diagnoses and The Importance of Clinical Correlation
title_full Lipid Keratopathy: Histopathology, Major Differential Diagnoses and The Importance of Clinical Correlation
title_fullStr Lipid Keratopathy: Histopathology, Major Differential Diagnoses and The Importance of Clinical Correlation
title_full_unstemmed Lipid Keratopathy: Histopathology, Major Differential Diagnoses and The Importance of Clinical Correlation
title_short Lipid Keratopathy: Histopathology, Major Differential Diagnoses and The Importance of Clinical Correlation
title_sort lipid keratopathy: histopathology, major differential diagnoses and the importance of clinical correlation
topic Interesting Images
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178412/
https://www.ncbi.nlm.nih.gov/pubmed/37175019
http://dx.doi.org/10.3390/diagnostics13091628
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