Topical Alginate Protection against Pepsin-Mediated Esophageal Damage: E-Cadherin Proteolysis and Matrix Metalloproteinase Induction

Epithelial barrier dysfunction is a hallmark of gastroesophageal reflux disease (GERD) related to symptom origination, inflammatory remodeling and carcinogenesis. Alginate-based antireflux medications were previously shown to topically protect against peptic barrier disruption, yet the molecular mec...

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Detalles Bibliográficos
Autores principales: Samuels, Tina L., Blaine-Sauer, Simon, Yan, Ke, Plehhova, Kate, Coyle, Cathal, Johnston, Nikki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178445/
https://www.ncbi.nlm.nih.gov/pubmed/37175640
http://dx.doi.org/10.3390/ijms24097932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178445/
https://www.ncbi.nlm.nih.gov/pubmed/37175640
http://dx.doi.org/10.3390/ijms24097932

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