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Development and implementation of an automated and highly accurate reporting process for NGS-based clonality testing
B and T cells undergo random recombination of the VH/DH/JH portions of the immunoglobulin loci (B cell) and T-cell receptors before becoming functional cells. When one V-J rearrangement is over-represented in a population of B or T cells indicating an origin from a single cell, this indicates a clon...
Autores principales: | Glenn, Sean T., Galbo, Phillip M., Luce, Jesse D., Miles, Kiersten Marie, Singh, Prashant K., Glynias, Manuel J., Morrison, Carl |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178459/ https://www.ncbi.nlm.nih.gov/pubmed/37171376 http://dx.doi.org/10.18632/oncotarget.28429 |
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