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Impact of COVID-19 on Adherence to Treatment in Patients with HIV

In patients with human immunodeficiency virus (HIV), adherence to treatment is affected by the adverse effects of treatment, the presence of additional comorbidities, the complexity of dosage, and family and community support. However, one recent circumstance that was likely to have influenced thera...

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Autores principales: Carbonero-Lechuga, Pablo, Castrodeza-Sanz, Javier, Sanz-Muñoz, Iván, Marqués-Sánchez, Pilar, Eiros, Jose M., Dueñas-Gutiérrez, Carlos, Prada-García, Camino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178482/
https://www.ncbi.nlm.nih.gov/pubmed/37174841
http://dx.doi.org/10.3390/healthcare11091299
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author Carbonero-Lechuga, Pablo
Castrodeza-Sanz, Javier
Sanz-Muñoz, Iván
Marqués-Sánchez, Pilar
Eiros, Jose M.
Dueñas-Gutiérrez, Carlos
Prada-García, Camino
author_facet Carbonero-Lechuga, Pablo
Castrodeza-Sanz, Javier
Sanz-Muñoz, Iván
Marqués-Sánchez, Pilar
Eiros, Jose M.
Dueñas-Gutiérrez, Carlos
Prada-García, Camino
author_sort Carbonero-Lechuga, Pablo
collection PubMed
description In patients with human immunodeficiency virus (HIV), adherence to treatment is affected by the adverse effects of treatment, the presence of additional comorbidities, the complexity of dosage, and family and community support. However, one recent circumstance that was likely to have influenced therapeutic adherence was the COVID-19 pandemic and the applied containment measures. An observational retrospective study of a sample of patients with HIV was conducted to establish the relationship between sociodemographic, clinical, and pharmacological variables and therapeutic adherence before and after the pandemic. Adherence was measured using the validated simplified medication adherence questionnaire (SMAQ) and medication possession rate. A statistical analysis was performed to determine the mean, standard deviation, and median of the quantitative variables and the frequencies of the qualitative variables, and the relationship between the dependent and independent variables was analysed using the chi-squared test and Student’s t-test. No statistically significant differences were found between treatment adherence measured before and 22 months after the start of the pandemic. Sex, occupation, treatment regimen, viral load levels, and COVID-19 disease status did not influence adherence during either period. However, the age of patients with HIV had an impact on adherence during both periods (p = 0.008 and p = 0.002, respectively), with the age group under 45 years being less adherent. In addition, experiencing adverse drug reactions (ADRs) was shown to have an impact on adherence before the pandemic (p = 0.006) but not afterwards. The COVID-19 pandemic was not shown to have an impact on the degree of adherence to antiretroviral treatment in patients with HIV. Instead, adherence was influenced by patient age and ADR occurrence; therefore, measures must be taken in this regard. The SMAQ demonstrated sensitivity in assessing adherence.
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spelling pubmed-101784822023-05-13 Impact of COVID-19 on Adherence to Treatment in Patients with HIV Carbonero-Lechuga, Pablo Castrodeza-Sanz, Javier Sanz-Muñoz, Iván Marqués-Sánchez, Pilar Eiros, Jose M. Dueñas-Gutiérrez, Carlos Prada-García, Camino Healthcare (Basel) Article In patients with human immunodeficiency virus (HIV), adherence to treatment is affected by the adverse effects of treatment, the presence of additional comorbidities, the complexity of dosage, and family and community support. However, one recent circumstance that was likely to have influenced therapeutic adherence was the COVID-19 pandemic and the applied containment measures. An observational retrospective study of a sample of patients with HIV was conducted to establish the relationship between sociodemographic, clinical, and pharmacological variables and therapeutic adherence before and after the pandemic. Adherence was measured using the validated simplified medication adherence questionnaire (SMAQ) and medication possession rate. A statistical analysis was performed to determine the mean, standard deviation, and median of the quantitative variables and the frequencies of the qualitative variables, and the relationship between the dependent and independent variables was analysed using the chi-squared test and Student’s t-test. No statistically significant differences were found between treatment adherence measured before and 22 months after the start of the pandemic. Sex, occupation, treatment regimen, viral load levels, and COVID-19 disease status did not influence adherence during either period. However, the age of patients with HIV had an impact on adherence during both periods (p = 0.008 and p = 0.002, respectively), with the age group under 45 years being less adherent. In addition, experiencing adverse drug reactions (ADRs) was shown to have an impact on adherence before the pandemic (p = 0.006) but not afterwards. The COVID-19 pandemic was not shown to have an impact on the degree of adherence to antiretroviral treatment in patients with HIV. Instead, adherence was influenced by patient age and ADR occurrence; therefore, measures must be taken in this regard. The SMAQ demonstrated sensitivity in assessing adherence. MDPI 2023-05-02 /pmc/articles/PMC10178482/ /pubmed/37174841 http://dx.doi.org/10.3390/healthcare11091299 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Carbonero-Lechuga, Pablo
Castrodeza-Sanz, Javier
Sanz-Muñoz, Iván
Marqués-Sánchez, Pilar
Eiros, Jose M.
Dueñas-Gutiérrez, Carlos
Prada-García, Camino
Impact of COVID-19 on Adherence to Treatment in Patients with HIV
title Impact of COVID-19 on Adherence to Treatment in Patients with HIV
title_full Impact of COVID-19 on Adherence to Treatment in Patients with HIV
title_fullStr Impact of COVID-19 on Adherence to Treatment in Patients with HIV
title_full_unstemmed Impact of COVID-19 on Adherence to Treatment in Patients with HIV
title_short Impact of COVID-19 on Adherence to Treatment in Patients with HIV
title_sort impact of covid-19 on adherence to treatment in patients with hiv
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178482/
https://www.ncbi.nlm.nih.gov/pubmed/37174841
http://dx.doi.org/10.3390/healthcare11091299
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