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Potential Role of AGR2 for Mammalian Skin Wound Healing

The limited ability of mammals to regenerate has garnered significant attention, particularly in regard to skin wound healing (WH), which is a critical step for regeneration. In human adults, skin WH results in the formation of scars following injury or trauma, regardless of severity. This differs s...

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Autores principales: Kosykh, Anastasiya V., Tereshina, Maria B., Gurskaya, Nadya G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178616/
https://www.ncbi.nlm.nih.gov/pubmed/37175601
http://dx.doi.org/10.3390/ijms24097895
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author Kosykh, Anastasiya V.
Tereshina, Maria B.
Gurskaya, Nadya G.
author_facet Kosykh, Anastasiya V.
Tereshina, Maria B.
Gurskaya, Nadya G.
author_sort Kosykh, Anastasiya V.
collection PubMed
description The limited ability of mammals to regenerate has garnered significant attention, particularly in regard to skin wound healing (WH), which is a critical step for regeneration. In human adults, skin WH results in the formation of scars following injury or trauma, regardless of severity. This differs significantly from the scarless WH observed in the fetal skin of mammals or anamniotes. This review investigates the role of molecular players involved in scarless WH, which are lost or repressed in adult mammalian WH systems. Specifically, we analyze the physiological role of Anterior Gradient (AGR) family proteins at different stages of the WH regulatory network. AGR is activated in the regeneration of lower vertebrates at the stage of wound closure and, accordingly, is important for WH. Mammalian AGR2 is expressed during scarless WH in embryonic skin, while in adults, the activity of this gene is normally inhibited and is observed only in the mucous epithelium of the digestive tract, which is capable of full regeneration. The combination of AGR2 unique potencies in postnatal mammals makes it possible to consider it as a promising candidate for enhancing WH processes.
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spelling pubmed-101786162023-05-13 Potential Role of AGR2 for Mammalian Skin Wound Healing Kosykh, Anastasiya V. Tereshina, Maria B. Gurskaya, Nadya G. Int J Mol Sci Review The limited ability of mammals to regenerate has garnered significant attention, particularly in regard to skin wound healing (WH), which is a critical step for regeneration. In human adults, skin WH results in the formation of scars following injury or trauma, regardless of severity. This differs significantly from the scarless WH observed in the fetal skin of mammals or anamniotes. This review investigates the role of molecular players involved in scarless WH, which are lost or repressed in adult mammalian WH systems. Specifically, we analyze the physiological role of Anterior Gradient (AGR) family proteins at different stages of the WH regulatory network. AGR is activated in the regeneration of lower vertebrates at the stage of wound closure and, accordingly, is important for WH. Mammalian AGR2 is expressed during scarless WH in embryonic skin, while in adults, the activity of this gene is normally inhibited and is observed only in the mucous epithelium of the digestive tract, which is capable of full regeneration. The combination of AGR2 unique potencies in postnatal mammals makes it possible to consider it as a promising candidate for enhancing WH processes. MDPI 2023-04-26 /pmc/articles/PMC10178616/ /pubmed/37175601 http://dx.doi.org/10.3390/ijms24097895 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kosykh, Anastasiya V.
Tereshina, Maria B.
Gurskaya, Nadya G.
Potential Role of AGR2 for Mammalian Skin Wound Healing
title Potential Role of AGR2 for Mammalian Skin Wound Healing
title_full Potential Role of AGR2 for Mammalian Skin Wound Healing
title_fullStr Potential Role of AGR2 for Mammalian Skin Wound Healing
title_full_unstemmed Potential Role of AGR2 for Mammalian Skin Wound Healing
title_short Potential Role of AGR2 for Mammalian Skin Wound Healing
title_sort potential role of agr2 for mammalian skin wound healing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178616/
https://www.ncbi.nlm.nih.gov/pubmed/37175601
http://dx.doi.org/10.3390/ijms24097895
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