The Role of NQO1 in Ovarian Cancer

Ovarian cancer is one of the most dangerous gynecologic malignancies showing a high fatality rate because of late diagnosis and relapse occurrence due to chemoresistance onset. Several researchers reported that oxidative stress plays a key role in ovarian cancer occurrence, growth and development. T...

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Detalles Bibliográficos
Autores principales: Tossetta, Giovanni, Fantone, Sonia, Goteri, Gaia, Giannubilo, Stefano Raffaele, Ciavattini, Andrea, Marzioni, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178676/
https://www.ncbi.nlm.nih.gov/pubmed/37175546
http://dx.doi.org/10.3390/ijms24097839
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author Tossetta, Giovanni
Fantone, Sonia
Goteri, Gaia
Giannubilo, Stefano Raffaele
Ciavattini, Andrea
Marzioni, Daniela
author_facet Tossetta, Giovanni
Fantone, Sonia
Goteri, Gaia
Giannubilo, Stefano Raffaele
Ciavattini, Andrea
Marzioni, Daniela
author_sort Tossetta, Giovanni
collection PubMed
description Ovarian cancer is one of the most dangerous gynecologic malignancies showing a high fatality rate because of late diagnosis and relapse occurrence due to chemoresistance onset. Several researchers reported that oxidative stress plays a key role in ovarian cancer occurrence, growth and development. The NAD(P)H:quinone oxidoreductase 1 (NQO1) is an antioxidant enzyme that, using NADH or NADPH as substrates to reduce quinones to hydroquinones, avoids the formation of the highly reactive semiquinones, then protecting cells against oxidative stress. In this review, we report evidence from the literature describing the effect of NQO1 on ovarian cancer onset and progression.
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spelling pubmed-101786762023-05-13 The Role of NQO1 in Ovarian Cancer Tossetta, Giovanni Fantone, Sonia Goteri, Gaia Giannubilo, Stefano Raffaele Ciavattini, Andrea Marzioni, Daniela Int J Mol Sci Review Ovarian cancer is one of the most dangerous gynecologic malignancies showing a high fatality rate because of late diagnosis and relapse occurrence due to chemoresistance onset. Several researchers reported that oxidative stress plays a key role in ovarian cancer occurrence, growth and development. The NAD(P)H:quinone oxidoreductase 1 (NQO1) is an antioxidant enzyme that, using NADH or NADPH as substrates to reduce quinones to hydroquinones, avoids the formation of the highly reactive semiquinones, then protecting cells against oxidative stress. In this review, we report evidence from the literature describing the effect of NQO1 on ovarian cancer onset and progression. MDPI 2023-04-25 /pmc/articles/PMC10178676/ /pubmed/37175546 http://dx.doi.org/10.3390/ijms24097839 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tossetta, Giovanni
Fantone, Sonia
Goteri, Gaia
Giannubilo, Stefano Raffaele
Ciavattini, Andrea
Marzioni, Daniela
The Role of NQO1 in Ovarian Cancer
title The Role of NQO1 in Ovarian Cancer
title_full The Role of NQO1 in Ovarian Cancer
title_fullStr The Role of NQO1 in Ovarian Cancer
title_full_unstemmed The Role of NQO1 in Ovarian Cancer
title_short The Role of NQO1 in Ovarian Cancer
title_sort role of nqo1 in ovarian cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178676/
https://www.ncbi.nlm.nih.gov/pubmed/37175546
http://dx.doi.org/10.3390/ijms24097839
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