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Drug-Induced Enterocolitis Syndrome in Children
Drug-Induced Enterocolitis Syndrome (DIES) is a drug-induced hypersensitivity reaction non-IgE mediated involving the gastrointestinal system that occurs 2 to 4 h after drug administration. Antibiotics, specifically amoxicillin or amoxicillin/clavulanate, represent the most frequent drugs involved....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178722/ https://www.ncbi.nlm.nih.gov/pubmed/37175584 http://dx.doi.org/10.3390/ijms24097880 |
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author | Di Filippo, Paola Venanzi, Annamaria Ciarelli, Francesca Panetti, Beatrice Di Pillo, Sabrina Chiarelli, Francesco Attanasi, Marina |
author_facet | Di Filippo, Paola Venanzi, Annamaria Ciarelli, Francesca Panetti, Beatrice Di Pillo, Sabrina Chiarelli, Francesco Attanasi, Marina |
author_sort | Di Filippo, Paola |
collection | PubMed |
description | Drug-Induced Enterocolitis Syndrome (DIES) is a drug-induced hypersensitivity reaction non-IgE mediated involving the gastrointestinal system that occurs 2 to 4 h after drug administration. Antibiotics, specifically amoxicillin or amoxicillin/clavulanate, represent the most frequent drugs involved. Symptoms include nausea, vomiting, abdominal pain, diarrhea, pallor, lethargy, and dehydration, which can be severe and result in hypovolemic shock. The main laboratory finding is neutrophilic leukocytosis. To the best of our knowledge, 12 cases of DIES (9 children-onset and 3 adult-onset cases) were described in the literature. DIES is a rare clinically well-described allergic disease; however, the pathogenetic mechanism is still unclear. It requires to be recognized early and correctly treated by physicians. |
format | Online Article Text |
id | pubmed-10178722 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101787222023-05-13 Drug-Induced Enterocolitis Syndrome in Children Di Filippo, Paola Venanzi, Annamaria Ciarelli, Francesca Panetti, Beatrice Di Pillo, Sabrina Chiarelli, Francesco Attanasi, Marina Int J Mol Sci Review Drug-Induced Enterocolitis Syndrome (DIES) is a drug-induced hypersensitivity reaction non-IgE mediated involving the gastrointestinal system that occurs 2 to 4 h after drug administration. Antibiotics, specifically amoxicillin or amoxicillin/clavulanate, represent the most frequent drugs involved. Symptoms include nausea, vomiting, abdominal pain, diarrhea, pallor, lethargy, and dehydration, which can be severe and result in hypovolemic shock. The main laboratory finding is neutrophilic leukocytosis. To the best of our knowledge, 12 cases of DIES (9 children-onset and 3 adult-onset cases) were described in the literature. DIES is a rare clinically well-described allergic disease; however, the pathogenetic mechanism is still unclear. It requires to be recognized early and correctly treated by physicians. MDPI 2023-04-26 /pmc/articles/PMC10178722/ /pubmed/37175584 http://dx.doi.org/10.3390/ijms24097880 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Di Filippo, Paola Venanzi, Annamaria Ciarelli, Francesca Panetti, Beatrice Di Pillo, Sabrina Chiarelli, Francesco Attanasi, Marina Drug-Induced Enterocolitis Syndrome in Children |
title | Drug-Induced Enterocolitis Syndrome in Children |
title_full | Drug-Induced Enterocolitis Syndrome in Children |
title_fullStr | Drug-Induced Enterocolitis Syndrome in Children |
title_full_unstemmed | Drug-Induced Enterocolitis Syndrome in Children |
title_short | Drug-Induced Enterocolitis Syndrome in Children |
title_sort | drug-induced enterocolitis syndrome in children |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178722/ https://www.ncbi.nlm.nih.gov/pubmed/37175584 http://dx.doi.org/10.3390/ijms24097880 |
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