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Drug-Induced Enterocolitis Syndrome in Children

Drug-Induced Enterocolitis Syndrome (DIES) is a drug-induced hypersensitivity reaction non-IgE mediated involving the gastrointestinal system that occurs 2 to 4 h after drug administration. Antibiotics, specifically amoxicillin or amoxicillin/clavulanate, represent the most frequent drugs involved....

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Autores principales: Di Filippo, Paola, Venanzi, Annamaria, Ciarelli, Francesca, Panetti, Beatrice, Di Pillo, Sabrina, Chiarelli, Francesco, Attanasi, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178722/
https://www.ncbi.nlm.nih.gov/pubmed/37175584
http://dx.doi.org/10.3390/ijms24097880
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author Di Filippo, Paola
Venanzi, Annamaria
Ciarelli, Francesca
Panetti, Beatrice
Di Pillo, Sabrina
Chiarelli, Francesco
Attanasi, Marina
author_facet Di Filippo, Paola
Venanzi, Annamaria
Ciarelli, Francesca
Panetti, Beatrice
Di Pillo, Sabrina
Chiarelli, Francesco
Attanasi, Marina
author_sort Di Filippo, Paola
collection PubMed
description Drug-Induced Enterocolitis Syndrome (DIES) is a drug-induced hypersensitivity reaction non-IgE mediated involving the gastrointestinal system that occurs 2 to 4 h after drug administration. Antibiotics, specifically amoxicillin or amoxicillin/clavulanate, represent the most frequent drugs involved. Symptoms include nausea, vomiting, abdominal pain, diarrhea, pallor, lethargy, and dehydration, which can be severe and result in hypovolemic shock. The main laboratory finding is neutrophilic leukocytosis. To the best of our knowledge, 12 cases of DIES (9 children-onset and 3 adult-onset cases) were described in the literature. DIES is a rare clinically well-described allergic disease; however, the pathogenetic mechanism is still unclear. It requires to be recognized early and correctly treated by physicians.
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spelling pubmed-101787222023-05-13 Drug-Induced Enterocolitis Syndrome in Children Di Filippo, Paola Venanzi, Annamaria Ciarelli, Francesca Panetti, Beatrice Di Pillo, Sabrina Chiarelli, Francesco Attanasi, Marina Int J Mol Sci Review Drug-Induced Enterocolitis Syndrome (DIES) is a drug-induced hypersensitivity reaction non-IgE mediated involving the gastrointestinal system that occurs 2 to 4 h after drug administration. Antibiotics, specifically amoxicillin or amoxicillin/clavulanate, represent the most frequent drugs involved. Symptoms include nausea, vomiting, abdominal pain, diarrhea, pallor, lethargy, and dehydration, which can be severe and result in hypovolemic shock. The main laboratory finding is neutrophilic leukocytosis. To the best of our knowledge, 12 cases of DIES (9 children-onset and 3 adult-onset cases) were described in the literature. DIES is a rare clinically well-described allergic disease; however, the pathogenetic mechanism is still unclear. It requires to be recognized early and correctly treated by physicians. MDPI 2023-04-26 /pmc/articles/PMC10178722/ /pubmed/37175584 http://dx.doi.org/10.3390/ijms24097880 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Di Filippo, Paola
Venanzi, Annamaria
Ciarelli, Francesca
Panetti, Beatrice
Di Pillo, Sabrina
Chiarelli, Francesco
Attanasi, Marina
Drug-Induced Enterocolitis Syndrome in Children
title Drug-Induced Enterocolitis Syndrome in Children
title_full Drug-Induced Enterocolitis Syndrome in Children
title_fullStr Drug-Induced Enterocolitis Syndrome in Children
title_full_unstemmed Drug-Induced Enterocolitis Syndrome in Children
title_short Drug-Induced Enterocolitis Syndrome in Children
title_sort drug-induced enterocolitis syndrome in children
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178722/
https://www.ncbi.nlm.nih.gov/pubmed/37175584
http://dx.doi.org/10.3390/ijms24097880
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