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Association between PAI-1 Polymorphisms and Ischemic Stroke in a South Korean Case-Control Cohort
Stroke is the second leading cause of death in the world. Approximately 80% of strokes are ischemic in origin. Many risk factors have been linked to stroke, including an increased level of plasminogen activator inhibitor-1 (PAI-1). PAI-1 levels increase and remain elevated in blood during the acute...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178745/ https://www.ncbi.nlm.nih.gov/pubmed/37175749 http://dx.doi.org/10.3390/ijms24098041 |
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author | Choi, Gun Ho Cho, Sung Hwan An, Hui Jeong Park, Han Sung Lee, Jeong Yong Ko, Eun Ju Oh, Seung Hun Kim, Ok Joon Kim, Nam Keun |
author_facet | Choi, Gun Ho Cho, Sung Hwan An, Hui Jeong Park, Han Sung Lee, Jeong Yong Ko, Eun Ju Oh, Seung Hun Kim, Ok Joon Kim, Nam Keun |
author_sort | Choi, Gun Ho |
collection | PubMed |
description | Stroke is the second leading cause of death in the world. Approximately 80% of strokes are ischemic in origin. Many risk factors have been linked to stroke, including an increased level of plasminogen activator inhibitor-1 (PAI-1). PAI-1 levels increase and remain elevated in blood during the acute phase of ischemic stroke, which can impair fibrinolytic activity, leading to coronary artery disease and arterial thrombotic disorders. Here, we present a case-control study of 574 stroke patients and 425 controls seen for routine health examination or treatment for nonspecific dizziness, nonorganic headache, or anxiety for positive family history of stroke at the Bundang Medical Center in South Korea. Polymorphisms in PAI-1 were identified by polymerase chain reaction/restriction fragment length polymorphism analysis using genomic DNA. Specifically, three variations (−675 4G>5G, 10692T>C, and 12068G>A) were linked to a higher overall prevalence of stroke as well as a higher prevalence of certain stroke subtypes. Haplotype analyses also revealed combinations of these variations (−844G>A, −675 4G>5G, 43G>A, 9785A>G, 10692T>C, 11053T>G, and 12068G>A) that were significantly associated with a higher prevalence of ischemic stroke. To the best of our knowledge, this is the first strong evidence that polymorphic sites in PAI-1 promoter and 3′-UTR regions are associated with higher ischemic stroke risk. Furthermore, the PAI-1 genotypes and haplotypes identified here have potential as clinical biomarkers of ischemic stroke and could improve the prognosis and future management of stroke patients. |
format | Online Article Text |
id | pubmed-10178745 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101787452023-05-13 Association between PAI-1 Polymorphisms and Ischemic Stroke in a South Korean Case-Control Cohort Choi, Gun Ho Cho, Sung Hwan An, Hui Jeong Park, Han Sung Lee, Jeong Yong Ko, Eun Ju Oh, Seung Hun Kim, Ok Joon Kim, Nam Keun Int J Mol Sci Article Stroke is the second leading cause of death in the world. Approximately 80% of strokes are ischemic in origin. Many risk factors have been linked to stroke, including an increased level of plasminogen activator inhibitor-1 (PAI-1). PAI-1 levels increase and remain elevated in blood during the acute phase of ischemic stroke, which can impair fibrinolytic activity, leading to coronary artery disease and arterial thrombotic disorders. Here, we present a case-control study of 574 stroke patients and 425 controls seen for routine health examination or treatment for nonspecific dizziness, nonorganic headache, or anxiety for positive family history of stroke at the Bundang Medical Center in South Korea. Polymorphisms in PAI-1 were identified by polymerase chain reaction/restriction fragment length polymorphism analysis using genomic DNA. Specifically, three variations (−675 4G>5G, 10692T>C, and 12068G>A) were linked to a higher overall prevalence of stroke as well as a higher prevalence of certain stroke subtypes. Haplotype analyses also revealed combinations of these variations (−844G>A, −675 4G>5G, 43G>A, 9785A>G, 10692T>C, 11053T>G, and 12068G>A) that were significantly associated with a higher prevalence of ischemic stroke. To the best of our knowledge, this is the first strong evidence that polymorphic sites in PAI-1 promoter and 3′-UTR regions are associated with higher ischemic stroke risk. Furthermore, the PAI-1 genotypes and haplotypes identified here have potential as clinical biomarkers of ischemic stroke and could improve the prognosis and future management of stroke patients. MDPI 2023-04-28 /pmc/articles/PMC10178745/ /pubmed/37175749 http://dx.doi.org/10.3390/ijms24098041 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Choi, Gun Ho Cho, Sung Hwan An, Hui Jeong Park, Han Sung Lee, Jeong Yong Ko, Eun Ju Oh, Seung Hun Kim, Ok Joon Kim, Nam Keun Association between PAI-1 Polymorphisms and Ischemic Stroke in a South Korean Case-Control Cohort |
title | Association between PAI-1 Polymorphisms and Ischemic Stroke in a South Korean Case-Control Cohort |
title_full | Association between PAI-1 Polymorphisms and Ischemic Stroke in a South Korean Case-Control Cohort |
title_fullStr | Association between PAI-1 Polymorphisms and Ischemic Stroke in a South Korean Case-Control Cohort |
title_full_unstemmed | Association between PAI-1 Polymorphisms and Ischemic Stroke in a South Korean Case-Control Cohort |
title_short | Association between PAI-1 Polymorphisms and Ischemic Stroke in a South Korean Case-Control Cohort |
title_sort | association between pai-1 polymorphisms and ischemic stroke in a south korean case-control cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178745/ https://www.ncbi.nlm.nih.gov/pubmed/37175749 http://dx.doi.org/10.3390/ijms24098041 |
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