Cargando…

Five-Year Changes in Inflammatory, Metabolic, and Oxidative Biomarkers and 10-Year Cardiovascular Disease Incidence: The REGICOR Cohort Study

Ischemic cardiovascular diseases (CVD) originate from an imbalance between atherosclerotic plaque formation, instability, and endothelial healing dynamics. Our aim was to examine the relationship between 5-year changes in inflammatory, metabolic, and oxidative biomarkers and 10-year CVD incidence in...

Descripción completa

Detalles Bibliográficos
Autores principales: Camps-Vilaro, Anna, Subirana, Isaac, Ramos, Rafel, Cainzos-Achirica, Miguel, Tizon-Marcos, Helena, Fito, Montse, Degano, Irene R., Marrugat, Jaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178750/
https://www.ncbi.nlm.nih.gov/pubmed/37175639
http://dx.doi.org/10.3390/ijms24097934
_version_ 1785040935255539712
author Camps-Vilaro, Anna
Subirana, Isaac
Ramos, Rafel
Cainzos-Achirica, Miguel
Tizon-Marcos, Helena
Fito, Montse
Degano, Irene R.
Marrugat, Jaume
author_facet Camps-Vilaro, Anna
Subirana, Isaac
Ramos, Rafel
Cainzos-Achirica, Miguel
Tizon-Marcos, Helena
Fito, Montse
Degano, Irene R.
Marrugat, Jaume
author_sort Camps-Vilaro, Anna
collection PubMed
description Ischemic cardiovascular diseases (CVD) originate from an imbalance between atherosclerotic plaque formation, instability, and endothelial healing dynamics. Our aim was to examine the relationship between 5-year changes in inflammatory, metabolic, and oxidative biomarkers and 10-year CVD incidence in a population without previous CVD. This was a prospective cohort study of individuals aged 35–74 years (n = 419) randomly selected from 5263 REGICOR participants without CVD recruited in 2005. Biomarkers were measured at baseline and in 2010. Participants were followed up until 2020 for a composite CVD endpoint including coronary artery disease, stroke, and peripheral artery disease. We used Cox regression to analyze the effect of biomarker levels on the occurrence of the composite endpoint, adjusted for traditional CVD risk factors and baseline levels of each biomarker. Individuals with elevated IL-6 or insulin after 5 years had a higher independent risk of CVD at 10 years, compared to those with lower levels. Each rise of 1 pg/mL of IL-6 or 10 pg/mL of insulin increased the 10-year risk of a CVD event by 32% and 2%, respectively. Compared to a model with traditional CVD risk factors only, the inclusion of IL-6 and insulin improved continuous reclassification by 51%. Elevated serum levels of IL-6 and insulin were associated with a higher risk of CVD at 10 years, independently of traditional CVD risk factors.
format Online
Article
Text
id pubmed-10178750
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-101787502023-05-13 Five-Year Changes in Inflammatory, Metabolic, and Oxidative Biomarkers and 10-Year Cardiovascular Disease Incidence: The REGICOR Cohort Study Camps-Vilaro, Anna Subirana, Isaac Ramos, Rafel Cainzos-Achirica, Miguel Tizon-Marcos, Helena Fito, Montse Degano, Irene R. Marrugat, Jaume Int J Mol Sci Article Ischemic cardiovascular diseases (CVD) originate from an imbalance between atherosclerotic plaque formation, instability, and endothelial healing dynamics. Our aim was to examine the relationship between 5-year changes in inflammatory, metabolic, and oxidative biomarkers and 10-year CVD incidence in a population without previous CVD. This was a prospective cohort study of individuals aged 35–74 years (n = 419) randomly selected from 5263 REGICOR participants without CVD recruited in 2005. Biomarkers were measured at baseline and in 2010. Participants were followed up until 2020 for a composite CVD endpoint including coronary artery disease, stroke, and peripheral artery disease. We used Cox regression to analyze the effect of biomarker levels on the occurrence of the composite endpoint, adjusted for traditional CVD risk factors and baseline levels of each biomarker. Individuals with elevated IL-6 or insulin after 5 years had a higher independent risk of CVD at 10 years, compared to those with lower levels. Each rise of 1 pg/mL of IL-6 or 10 pg/mL of insulin increased the 10-year risk of a CVD event by 32% and 2%, respectively. Compared to a model with traditional CVD risk factors only, the inclusion of IL-6 and insulin improved continuous reclassification by 51%. Elevated serum levels of IL-6 and insulin were associated with a higher risk of CVD at 10 years, independently of traditional CVD risk factors. MDPI 2023-04-27 /pmc/articles/PMC10178750/ /pubmed/37175639 http://dx.doi.org/10.3390/ijms24097934 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Camps-Vilaro, Anna
Subirana, Isaac
Ramos, Rafel
Cainzos-Achirica, Miguel
Tizon-Marcos, Helena
Fito, Montse
Degano, Irene R.
Marrugat, Jaume
Five-Year Changes in Inflammatory, Metabolic, and Oxidative Biomarkers and 10-Year Cardiovascular Disease Incidence: The REGICOR Cohort Study
title Five-Year Changes in Inflammatory, Metabolic, and Oxidative Biomarkers and 10-Year Cardiovascular Disease Incidence: The REGICOR Cohort Study
title_full Five-Year Changes in Inflammatory, Metabolic, and Oxidative Biomarkers and 10-Year Cardiovascular Disease Incidence: The REGICOR Cohort Study
title_fullStr Five-Year Changes in Inflammatory, Metabolic, and Oxidative Biomarkers and 10-Year Cardiovascular Disease Incidence: The REGICOR Cohort Study
title_full_unstemmed Five-Year Changes in Inflammatory, Metabolic, and Oxidative Biomarkers and 10-Year Cardiovascular Disease Incidence: The REGICOR Cohort Study
title_short Five-Year Changes in Inflammatory, Metabolic, and Oxidative Biomarkers and 10-Year Cardiovascular Disease Incidence: The REGICOR Cohort Study
title_sort five-year changes in inflammatory, metabolic, and oxidative biomarkers and 10-year cardiovascular disease incidence: the regicor cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178750/
https://www.ncbi.nlm.nih.gov/pubmed/37175639
http://dx.doi.org/10.3390/ijms24097934
work_keys_str_mv AT campsvilaroanna fiveyearchangesininflammatorymetabolicandoxidativebiomarkersand10yearcardiovasculardiseaseincidencetheregicorcohortstudy
AT subiranaisaac fiveyearchangesininflammatorymetabolicandoxidativebiomarkersand10yearcardiovasculardiseaseincidencetheregicorcohortstudy
AT ramosrafel fiveyearchangesininflammatorymetabolicandoxidativebiomarkersand10yearcardiovasculardiseaseincidencetheregicorcohortstudy
AT cainzosachiricamiguel fiveyearchangesininflammatorymetabolicandoxidativebiomarkersand10yearcardiovasculardiseaseincidencetheregicorcohortstudy
AT tizonmarcoshelena fiveyearchangesininflammatorymetabolicandoxidativebiomarkersand10yearcardiovasculardiseaseincidencetheregicorcohortstudy
AT fitomontse fiveyearchangesininflammatorymetabolicandoxidativebiomarkersand10yearcardiovasculardiseaseincidencetheregicorcohortstudy
AT deganoirener fiveyearchangesininflammatorymetabolicandoxidativebiomarkersand10yearcardiovasculardiseaseincidencetheregicorcohortstudy
AT marrugatjaume fiveyearchangesininflammatorymetabolicandoxidativebiomarkersand10yearcardiovasculardiseaseincidencetheregicorcohortstudy