SARS-CoV-2 Spike N-Terminal Domain Engages 9-O-Acetylated α2–8-Linked Sialic Acids

[Image: see text] SARS-CoV-2 viruses engage ACE2 as a functional receptor with their spike protein. The S1 domain of the spike protein contains a C-terminal receptor binding domain (RBD) and an N-terminal domain (NTD). The NTD of other coronaviruses includes a glycan binding cleft. However, for the...

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Detalles Bibliográficos
Autores principales: Tomris, Ilhan, Unione, Luca, Nguyen, Linh, Zaree, Pouya, Bouwman, Kim M., Liu, Lin, Li, Zeshi, Fok, Jelle A., Ríos Carrasco, María, van der Woude, Roosmarijn, Kimpel, Anne L. M., Linthorst, Mirte W., Kilavuzoglu, Sinan E., Verpalen, Enrico C. J. M., Caniels, Tom G., Sanders, Rogier W., Heesters, Balthasar A., Pieters, Roland J., Jiménez-Barbero, Jesús, Klassen, John S., Boons, Geert-Jan, de Vries, Robert P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178783/
https://www.ncbi.nlm.nih.gov/pubmed/37104622
http://dx.doi.org/10.1021/acschembio.3c00066

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