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A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain

[Image: see text] Viral macrodomains, which can bind to and/or hydrolyze adenine diphosphate ribose (ADP-ribose or ADPr) from proteins, have been suggested to counteract host immune response and be viable targets for the development of antiviral drugs. Therefore, developing high-throughput screening...

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Detalles Bibliográficos
Autores principales:	Anmangandla, Ananya, Jana, Sadhan, Peng, Kewen, Wallace, Shamar D., Bagde, Saket R., Drown, Bryon S., Xu, Jiashu, Hergenrother, Paul J., Fromme, J. Christopher, Lin, Hening
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178785/ https://www.ncbi.nlm.nih.gov/pubmed/37126856 http://dx.doi.org/10.1021/acschembio.3c00092

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