Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state

Childhood neuroblastomas exhibit plasticity between an undifferentiated neural crest–like mesenchymal cell state and a more differentiated sympathetic adrenergic cell state. These cell states are governed by autoregulatory transcriptional loops called core regulatory circuitries (CRCs), which drive...

Descripción completa

Detalles Bibliográficos
Autores principales: Weichert-Leahey, Nina, Shi, Hui, Tao, Ting, Oldridge, Derek A., Durbin, Adam D., Abraham, Brian J., Zimmerman, Mark W., Zhu, Shizhen, Wood, Andrew C., Reyon, Deepak, Joung, J. Keith, Young, Richard A., Diskin, Sharon J., Maris, John M., Look, A. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178836/
https://www.ncbi.nlm.nih.gov/pubmed/37183825
http://dx.doi.org/10.1172/JCI166919

Ejemplares similares

Ejemplares similares