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Pharmacologic improvement of CFTR function rapidly decreases sputum pathogen density, but lung infections generally persist

BACKGROUND: Lung infections are among the most consequential manifestations of cystic fibrosis (CF) and are associated with reduced lung function and shortened survival. Drugs called CF transmembrane conductance regulator (CFTR) modulators improve activity of dysfunctional CFTR channels, which is th...

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Detalles Bibliográficos
Autores principales:	Nichols, David P., Morgan, Sarah J., Skalland, Michelle, Vo, Anh T., Van Dalfsen, Jill M., Singh, Sachinkumar B.P., Ni, Wendy, Hoffman, Lucas R., McGeer, Kailee, Heltshe, Sonya L., Clancy, John P., Rowe, Steven M., Jorth, Peter, Singh, Pradeep K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Clinical Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178839/ https://www.ncbi.nlm.nih.gov/pubmed/36976651 http://dx.doi.org/10.1172/JCI167957

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