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Aqueous Humor Cytokine Profile in Primary Congenital Glaucoma

Background: Cytokine profile in patients with primary open-angle glaucoma (POAG) differs from that in healthy controls. Due to the different pathophysiological mechanisms involved in the genesis of primary congenital glaucoma (PCG) and POAG, it is possible that the cytokine profile could also differ...

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Autores principales: Oribio-Quinto, Carlos, Burgos-Blasco, Barbara, Pérez-García, Pilar, Espino-Paisán, Laura, Sarriá, Beatriz, Fernández-Vigo, José Ignacio, García-Feijóo, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178937/
https://www.ncbi.nlm.nih.gov/pubmed/37176583
http://dx.doi.org/10.3390/jcm12093142
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author Oribio-Quinto, Carlos
Burgos-Blasco, Barbara
Pérez-García, Pilar
Espino-Paisán, Laura
Sarriá, Beatriz
Fernández-Vigo, José Ignacio
García-Feijóo, Julian
author_facet Oribio-Quinto, Carlos
Burgos-Blasco, Barbara
Pérez-García, Pilar
Espino-Paisán, Laura
Sarriá, Beatriz
Fernández-Vigo, José Ignacio
García-Feijóo, Julian
author_sort Oribio-Quinto, Carlos
collection PubMed
description Background: Cytokine profile in patients with primary open-angle glaucoma (POAG) differs from that in healthy controls. Due to the different pathophysiological mechanisms involved in the genesis of primary congenital glaucoma (PCG) and POAG, it is possible that the cytokine profile could also differ. The main objective of this study was to compare the concentrations of cytokines in the aqueous humor of patients with PCG with those of POAG patients and a control group. Methods: A cross-sectional study was conducted. Aqueous humor samples were taken from PCG and POAG patients eligible for glaucoma or cataract surgery and from patients undergoing cataract surgery. Twenty-seven cytokines were analyzed using the Human Cytokine 27-Plex Immunoassay Kit (Bio-Rad Laboratories, Hercules, CA, USA). Results: A total of 107 subjects were included: patients with PCG (n = 19), patients with POAG (n = 54), and a control group (CG) of patients undergoing cataract surgery (n = 34). Most cytokines measured in aqueous humor in PCG presented decreased values compared with POAG and controls. A statistically significant difference was observed in IL-1ra, IL-2, IL-5, IL-7, IL-8, IL-10, IL-12, IL-15, IL-17A, Eotaxin, FGF basic, G-CSF, GM-CSF, IFN-γ, MIP-1α, PDGF-bb, MIP-1β, RANTES, TNF-α, and VEGF. Conclusion: PCG patients have a cytokine profile in aqueous humor different from POAG patients and patients without glaucoma, characterized by lower concentrations of multiple cytokines.
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spelling pubmed-101789372023-05-13 Aqueous Humor Cytokine Profile in Primary Congenital Glaucoma Oribio-Quinto, Carlos Burgos-Blasco, Barbara Pérez-García, Pilar Espino-Paisán, Laura Sarriá, Beatriz Fernández-Vigo, José Ignacio García-Feijóo, Julian J Clin Med Article Background: Cytokine profile in patients with primary open-angle glaucoma (POAG) differs from that in healthy controls. Due to the different pathophysiological mechanisms involved in the genesis of primary congenital glaucoma (PCG) and POAG, it is possible that the cytokine profile could also differ. The main objective of this study was to compare the concentrations of cytokines in the aqueous humor of patients with PCG with those of POAG patients and a control group. Methods: A cross-sectional study was conducted. Aqueous humor samples were taken from PCG and POAG patients eligible for glaucoma or cataract surgery and from patients undergoing cataract surgery. Twenty-seven cytokines were analyzed using the Human Cytokine 27-Plex Immunoassay Kit (Bio-Rad Laboratories, Hercules, CA, USA). Results: A total of 107 subjects were included: patients with PCG (n = 19), patients with POAG (n = 54), and a control group (CG) of patients undergoing cataract surgery (n = 34). Most cytokines measured in aqueous humor in PCG presented decreased values compared with POAG and controls. A statistically significant difference was observed in IL-1ra, IL-2, IL-5, IL-7, IL-8, IL-10, IL-12, IL-15, IL-17A, Eotaxin, FGF basic, G-CSF, GM-CSF, IFN-γ, MIP-1α, PDGF-bb, MIP-1β, RANTES, TNF-α, and VEGF. Conclusion: PCG patients have a cytokine profile in aqueous humor different from POAG patients and patients without glaucoma, characterized by lower concentrations of multiple cytokines. MDPI 2023-04-26 /pmc/articles/PMC10178937/ /pubmed/37176583 http://dx.doi.org/10.3390/jcm12093142 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Oribio-Quinto, Carlos
Burgos-Blasco, Barbara
Pérez-García, Pilar
Espino-Paisán, Laura
Sarriá, Beatriz
Fernández-Vigo, José Ignacio
García-Feijóo, Julian
Aqueous Humor Cytokine Profile in Primary Congenital Glaucoma
title Aqueous Humor Cytokine Profile in Primary Congenital Glaucoma
title_full Aqueous Humor Cytokine Profile in Primary Congenital Glaucoma
title_fullStr Aqueous Humor Cytokine Profile in Primary Congenital Glaucoma
title_full_unstemmed Aqueous Humor Cytokine Profile in Primary Congenital Glaucoma
title_short Aqueous Humor Cytokine Profile in Primary Congenital Glaucoma
title_sort aqueous humor cytokine profile in primary congenital glaucoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178937/
https://www.ncbi.nlm.nih.gov/pubmed/37176583
http://dx.doi.org/10.3390/jcm12093142
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