Role of the ABCA4 Gene Expression in the Clearance of Toxic Vitamin A Derivatives in Human Hair Follicle Stem Cells and Keratinocytes

The ABCA4 gene encodes an ATP-binding cassette transporter that is expressed specifically in the disc of photoreceptor outer segments. Mutations in the ABCA4 gene are the main cause of retinal degenerations known as “ABCA4-retinopathies.” Recent research has revealed that ABCA4 is expressed in other...

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Autores principales: Ścieżyńska, Aneta, Łuszczyński, Krzysztof, Radziszewski, Marcin, Komorowski, Michał, Soszyńska, Marta, Krześniak, Natalia, Shevchenko, Kateryna, Lutyńska, Anna, Malejczyk, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179012/
https://www.ncbi.nlm.nih.gov/pubmed/37175983
http://dx.doi.org/10.3390/ijms24098275
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author Ścieżyńska, Aneta
Łuszczyński, Krzysztof
Radziszewski, Marcin
Komorowski, Michał
Soszyńska, Marta
Krześniak, Natalia
Shevchenko, Kateryna
Lutyńska, Anna
Malejczyk, Jacek
author_facet Ścieżyńska, Aneta
Łuszczyński, Krzysztof
Radziszewski, Marcin
Komorowski, Michał
Soszyńska, Marta
Krześniak, Natalia
Shevchenko, Kateryna
Lutyńska, Anna
Malejczyk, Jacek
author_sort Ścieżyńska, Aneta
collection PubMed
description The ABCA4 gene encodes an ATP-binding cassette transporter that is expressed specifically in the disc of photoreceptor outer segments. Mutations in the ABCA4 gene are the main cause of retinal degenerations known as “ABCA4-retinopathies.” Recent research has revealed that ABCA4 is expressed in other cells as well, such as hair follicles and keratinocytes, although no information on its significance has been evidenced so far. In this study, we investigated the role of the ABCA4 gene in human keratinocytes and hair follicle stem cells for the first time. We have shown that silencing the ABCA4 gene increases the deleterious effect of all-trans-retinal on human hair follicle stem cells.
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spelling pubmed-101790122023-05-13 Role of the ABCA4 Gene Expression in the Clearance of Toxic Vitamin A Derivatives in Human Hair Follicle Stem Cells and Keratinocytes Ścieżyńska, Aneta Łuszczyński, Krzysztof Radziszewski, Marcin Komorowski, Michał Soszyńska, Marta Krześniak, Natalia Shevchenko, Kateryna Lutyńska, Anna Malejczyk, Jacek Int J Mol Sci Article The ABCA4 gene encodes an ATP-binding cassette transporter that is expressed specifically in the disc of photoreceptor outer segments. Mutations in the ABCA4 gene are the main cause of retinal degenerations known as “ABCA4-retinopathies.” Recent research has revealed that ABCA4 is expressed in other cells as well, such as hair follicles and keratinocytes, although no information on its significance has been evidenced so far. In this study, we investigated the role of the ABCA4 gene in human keratinocytes and hair follicle stem cells for the first time. We have shown that silencing the ABCA4 gene increases the deleterious effect of all-trans-retinal on human hair follicle stem cells. MDPI 2023-05-05 /pmc/articles/PMC10179012/ /pubmed/37175983 http://dx.doi.org/10.3390/ijms24098275 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ścieżyńska, Aneta
Łuszczyński, Krzysztof
Radziszewski, Marcin
Komorowski, Michał
Soszyńska, Marta
Krześniak, Natalia
Shevchenko, Kateryna
Lutyńska, Anna
Malejczyk, Jacek
Role of the ABCA4 Gene Expression in the Clearance of Toxic Vitamin A Derivatives in Human Hair Follicle Stem Cells and Keratinocytes
title Role of the ABCA4 Gene Expression in the Clearance of Toxic Vitamin A Derivatives in Human Hair Follicle Stem Cells and Keratinocytes
title_full Role of the ABCA4 Gene Expression in the Clearance of Toxic Vitamin A Derivatives in Human Hair Follicle Stem Cells and Keratinocytes
title_fullStr Role of the ABCA4 Gene Expression in the Clearance of Toxic Vitamin A Derivatives in Human Hair Follicle Stem Cells and Keratinocytes
title_full_unstemmed Role of the ABCA4 Gene Expression in the Clearance of Toxic Vitamin A Derivatives in Human Hair Follicle Stem Cells and Keratinocytes
title_short Role of the ABCA4 Gene Expression in the Clearance of Toxic Vitamin A Derivatives in Human Hair Follicle Stem Cells and Keratinocytes
title_sort role of the abca4 gene expression in the clearance of toxic vitamin a derivatives in human hair follicle stem cells and keratinocytes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179012/
https://www.ncbi.nlm.nih.gov/pubmed/37175983
http://dx.doi.org/10.3390/ijms24098275
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