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Association of Renin-Angiotensin System Blockers with Survival in Patients on Maintenance Hemodialysis

Additional studies are needed to confirm whether the use of renin-angiotensin system blockers (RASBs) induces survival benefits in patients on hemodialysis (HD). This study aimed to evaluate patient survival with the use of RASBs in a large sample of maintenance HD patients. This study used data fro...

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Autores principales: Kang, Seok Hui, Kim, Bo Yeon, Son, Eun Jung, Kim, Gui Ok, Do, Jun Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179028/
https://www.ncbi.nlm.nih.gov/pubmed/37176742
http://dx.doi.org/10.3390/jcm12093301
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author Kang, Seok Hui
Kim, Bo Yeon
Son, Eun Jung
Kim, Gui Ok
Do, Jun Young
author_facet Kang, Seok Hui
Kim, Bo Yeon
Son, Eun Jung
Kim, Gui Ok
Do, Jun Young
author_sort Kang, Seok Hui
collection PubMed
description Additional studies are needed to confirm whether the use of renin-angiotensin system blockers (RASBs) induces survival benefits in patients on hemodialysis (HD). This study aimed to evaluate patient survival with the use of RASBs in a large sample of maintenance HD patients. This study used data from the national HD quality assessment program and claim data from South Korea (n = 54,903). A patient using RASBs was defined as someone who had received more than one prescription during the 6 months of each HD quality assessment period. The patients were divided into three groups as follows: Group 1, no prescription for anti-hypertensive drugs; Group 2, prescription for anti-hypertensive drugs other than RASBs; and Group 3, prescription for RASBs. The five-year survival rates in Groups 1, 2, and 3 were 72.1%, 64.5%, and 66.6%, respectively (p < 0.001 for Group 1 vs. Group 2 or 3; p = 0.001 for Group 2 vs. Group 3). Group 1 had the highest patient survival rates among the three groups, and Group 3 had higher patient survival rates compared to Group 2. Group 3 had higher patient survival rates than Group 2; however, the difference in patient survival rates between Group 2 and Group 3 was relatively small. Multivariate Cox regression analyses showed similar trends as those of univariate analyses. The highest survival rates from our study were those of patients who had not used anti-hypertensive drugs. Between patients treated with RASBs and those with other anti-hypertensive drugs, patient survival rates were higher in patients treated with RASBs.
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spelling pubmed-101790282023-05-13 Association of Renin-Angiotensin System Blockers with Survival in Patients on Maintenance Hemodialysis Kang, Seok Hui Kim, Bo Yeon Son, Eun Jung Kim, Gui Ok Do, Jun Young J Clin Med Article Additional studies are needed to confirm whether the use of renin-angiotensin system blockers (RASBs) induces survival benefits in patients on hemodialysis (HD). This study aimed to evaluate patient survival with the use of RASBs in a large sample of maintenance HD patients. This study used data from the national HD quality assessment program and claim data from South Korea (n = 54,903). A patient using RASBs was defined as someone who had received more than one prescription during the 6 months of each HD quality assessment period. The patients were divided into three groups as follows: Group 1, no prescription for anti-hypertensive drugs; Group 2, prescription for anti-hypertensive drugs other than RASBs; and Group 3, prescription for RASBs. The five-year survival rates in Groups 1, 2, and 3 were 72.1%, 64.5%, and 66.6%, respectively (p < 0.001 for Group 1 vs. Group 2 or 3; p = 0.001 for Group 2 vs. Group 3). Group 1 had the highest patient survival rates among the three groups, and Group 3 had higher patient survival rates compared to Group 2. Group 3 had higher patient survival rates than Group 2; however, the difference in patient survival rates between Group 2 and Group 3 was relatively small. Multivariate Cox regression analyses showed similar trends as those of univariate analyses. The highest survival rates from our study were those of patients who had not used anti-hypertensive drugs. Between patients treated with RASBs and those with other anti-hypertensive drugs, patient survival rates were higher in patients treated with RASBs. MDPI 2023-05-05 /pmc/articles/PMC10179028/ /pubmed/37176742 http://dx.doi.org/10.3390/jcm12093301 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kang, Seok Hui
Kim, Bo Yeon
Son, Eun Jung
Kim, Gui Ok
Do, Jun Young
Association of Renin-Angiotensin System Blockers with Survival in Patients on Maintenance Hemodialysis
title Association of Renin-Angiotensin System Blockers with Survival in Patients on Maintenance Hemodialysis
title_full Association of Renin-Angiotensin System Blockers with Survival in Patients on Maintenance Hemodialysis
title_fullStr Association of Renin-Angiotensin System Blockers with Survival in Patients on Maintenance Hemodialysis
title_full_unstemmed Association of Renin-Angiotensin System Blockers with Survival in Patients on Maintenance Hemodialysis
title_short Association of Renin-Angiotensin System Blockers with Survival in Patients on Maintenance Hemodialysis
title_sort association of renin-angiotensin system blockers with survival in patients on maintenance hemodialysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179028/
https://www.ncbi.nlm.nih.gov/pubmed/37176742
http://dx.doi.org/10.3390/jcm12093301
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