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Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power

Impaired % predicted value forced vital capacity (% FVC) is related to higher all-cause mortality in aged adults, and strong muscle force may improve this relationship. A muscle disease, sarcopenia, causes higher mortality. We aimed to identify the unknown disease that relates impaired % FVC with hi...

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Autores principales: Shiokawa, Nanako, Okazaki, Tatsuma, Suzukamo, Yoshimi, Miyatake, Midori, Kogure, Mana, Nakaya, Naoki, Hozawa, Atsushi, Ebihara, Satoru, Izumi, Shin-Ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179042/
https://www.ncbi.nlm.nih.gov/pubmed/37176712
http://dx.doi.org/10.3390/jcm12093272
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author Shiokawa, Nanako
Okazaki, Tatsuma
Suzukamo, Yoshimi
Miyatake, Midori
Kogure, Mana
Nakaya, Naoki
Hozawa, Atsushi
Ebihara, Satoru
Izumi, Shin-Ichi
author_facet Shiokawa, Nanako
Okazaki, Tatsuma
Suzukamo, Yoshimi
Miyatake, Midori
Kogure, Mana
Nakaya, Naoki
Hozawa, Atsushi
Ebihara, Satoru
Izumi, Shin-Ichi
author_sort Shiokawa, Nanako
collection PubMed
description Impaired % predicted value forced vital capacity (% FVC) is related to higher all-cause mortality in aged adults, and strong muscle force may improve this relationship. A muscle disease, sarcopenia, causes higher mortality. We aimed to identify the unknown disease that relates impaired % FVC with higher mortality in aged adults among the three major leading causes of death, and the effect of strong leg force on this relationship. Cox proportional hazard model analyzed the longitudinal Tsurugaya cohort that registered 1048 aged Japanese for 11 years. The primary outcome was the relationship between % FVC and mortality by cancer, cardiovascular disease, or pneumonia. Exposure variables were % FVC or leg force divided by 80% or median values, respectively. The secondary outcome was the effects of leg force on the relationship. Among the diseases, % FVC < 80% was related only to higher pneumonia mortality (hazard ratio [HR], 4.09; 95% CI, 1.90–8.83) relative to the % FVC ≥ 80% group before adjustment. Adding the leg force as an explanatory variable reduced the HR to 3.34 (1.54–7.25). Weak leg force might indicate sarcopenia, and its prevention may improve higher pneumonia mortality risk related to impaired % FVC, which we may advise people in clinical settings.
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spelling pubmed-101790422023-05-13 Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power Shiokawa, Nanako Okazaki, Tatsuma Suzukamo, Yoshimi Miyatake, Midori Kogure, Mana Nakaya, Naoki Hozawa, Atsushi Ebihara, Satoru Izumi, Shin-Ichi J Clin Med Article Impaired % predicted value forced vital capacity (% FVC) is related to higher all-cause mortality in aged adults, and strong muscle force may improve this relationship. A muscle disease, sarcopenia, causes higher mortality. We aimed to identify the unknown disease that relates impaired % FVC with higher mortality in aged adults among the three major leading causes of death, and the effect of strong leg force on this relationship. Cox proportional hazard model analyzed the longitudinal Tsurugaya cohort that registered 1048 aged Japanese for 11 years. The primary outcome was the relationship between % FVC and mortality by cancer, cardiovascular disease, or pneumonia. Exposure variables were % FVC or leg force divided by 80% or median values, respectively. The secondary outcome was the effects of leg force on the relationship. Among the diseases, % FVC < 80% was related only to higher pneumonia mortality (hazard ratio [HR], 4.09; 95% CI, 1.90–8.83) relative to the % FVC ≥ 80% group before adjustment. Adding the leg force as an explanatory variable reduced the HR to 3.34 (1.54–7.25). Weak leg force might indicate sarcopenia, and its prevention may improve higher pneumonia mortality risk related to impaired % FVC, which we may advise people in clinical settings. MDPI 2023-05-04 /pmc/articles/PMC10179042/ /pubmed/37176712 http://dx.doi.org/10.3390/jcm12093272 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shiokawa, Nanako
Okazaki, Tatsuma
Suzukamo, Yoshimi
Miyatake, Midori
Kogure, Mana
Nakaya, Naoki
Hozawa, Atsushi
Ebihara, Satoru
Izumi, Shin-Ichi
Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power
title Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power
title_full Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power
title_fullStr Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power
title_full_unstemmed Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power
title_short Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power
title_sort association between low forced vital capacity and high pneumonia mortality, and impact of muscle power
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179042/
https://www.ncbi.nlm.nih.gov/pubmed/37176712
http://dx.doi.org/10.3390/jcm12093272
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