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Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power
Impaired % predicted value forced vital capacity (% FVC) is related to higher all-cause mortality in aged adults, and strong muscle force may improve this relationship. A muscle disease, sarcopenia, causes higher mortality. We aimed to identify the unknown disease that relates impaired % FVC with hi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179042/ https://www.ncbi.nlm.nih.gov/pubmed/37176712 http://dx.doi.org/10.3390/jcm12093272 |
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author | Shiokawa, Nanako Okazaki, Tatsuma Suzukamo, Yoshimi Miyatake, Midori Kogure, Mana Nakaya, Naoki Hozawa, Atsushi Ebihara, Satoru Izumi, Shin-Ichi |
author_facet | Shiokawa, Nanako Okazaki, Tatsuma Suzukamo, Yoshimi Miyatake, Midori Kogure, Mana Nakaya, Naoki Hozawa, Atsushi Ebihara, Satoru Izumi, Shin-Ichi |
author_sort | Shiokawa, Nanako |
collection | PubMed |
description | Impaired % predicted value forced vital capacity (% FVC) is related to higher all-cause mortality in aged adults, and strong muscle force may improve this relationship. A muscle disease, sarcopenia, causes higher mortality. We aimed to identify the unknown disease that relates impaired % FVC with higher mortality in aged adults among the three major leading causes of death, and the effect of strong leg force on this relationship. Cox proportional hazard model analyzed the longitudinal Tsurugaya cohort that registered 1048 aged Japanese for 11 years. The primary outcome was the relationship between % FVC and mortality by cancer, cardiovascular disease, or pneumonia. Exposure variables were % FVC or leg force divided by 80% or median values, respectively. The secondary outcome was the effects of leg force on the relationship. Among the diseases, % FVC < 80% was related only to higher pneumonia mortality (hazard ratio [HR], 4.09; 95% CI, 1.90–8.83) relative to the % FVC ≥ 80% group before adjustment. Adding the leg force as an explanatory variable reduced the HR to 3.34 (1.54–7.25). Weak leg force might indicate sarcopenia, and its prevention may improve higher pneumonia mortality risk related to impaired % FVC, which we may advise people in clinical settings. |
format | Online Article Text |
id | pubmed-10179042 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101790422023-05-13 Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power Shiokawa, Nanako Okazaki, Tatsuma Suzukamo, Yoshimi Miyatake, Midori Kogure, Mana Nakaya, Naoki Hozawa, Atsushi Ebihara, Satoru Izumi, Shin-Ichi J Clin Med Article Impaired % predicted value forced vital capacity (% FVC) is related to higher all-cause mortality in aged adults, and strong muscle force may improve this relationship. A muscle disease, sarcopenia, causes higher mortality. We aimed to identify the unknown disease that relates impaired % FVC with higher mortality in aged adults among the three major leading causes of death, and the effect of strong leg force on this relationship. Cox proportional hazard model analyzed the longitudinal Tsurugaya cohort that registered 1048 aged Japanese for 11 years. The primary outcome was the relationship between % FVC and mortality by cancer, cardiovascular disease, or pneumonia. Exposure variables were % FVC or leg force divided by 80% or median values, respectively. The secondary outcome was the effects of leg force on the relationship. Among the diseases, % FVC < 80% was related only to higher pneumonia mortality (hazard ratio [HR], 4.09; 95% CI, 1.90–8.83) relative to the % FVC ≥ 80% group before adjustment. Adding the leg force as an explanatory variable reduced the HR to 3.34 (1.54–7.25). Weak leg force might indicate sarcopenia, and its prevention may improve higher pneumonia mortality risk related to impaired % FVC, which we may advise people in clinical settings. MDPI 2023-05-04 /pmc/articles/PMC10179042/ /pubmed/37176712 http://dx.doi.org/10.3390/jcm12093272 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shiokawa, Nanako Okazaki, Tatsuma Suzukamo, Yoshimi Miyatake, Midori Kogure, Mana Nakaya, Naoki Hozawa, Atsushi Ebihara, Satoru Izumi, Shin-Ichi Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power |
title | Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power |
title_full | Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power |
title_fullStr | Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power |
title_full_unstemmed | Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power |
title_short | Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power |
title_sort | association between low forced vital capacity and high pneumonia mortality, and impact of muscle power |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179042/ https://www.ncbi.nlm.nih.gov/pubmed/37176712 http://dx.doi.org/10.3390/jcm12093272 |
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