Cargando…

Qualitative Assessment of Contrast-Enhanced Ultrasound in Differentiating Clear Cell Renal Cell Carcinoma and Oncocytoma

Background: We aimed to assess whether clear cell renal cell carcinoma (ccRCC) can be differentiated from renal oncocytoma (RO) on a contrast-enhanced ultrasound (CEUS). Methods: Between January 2021 and October 2022, we retrospectively queried and analyzed our prospectively maintained dataset. Rena...

Descripción completa

Detalles Bibliográficos
Autores principales: Tufano, Antonio, Leonardo, Costantino, Di Bella, Chiara, Lucarelli, Giuseppe, Dolcetti, Vincenzo, Dipinto, Piervito, Proietti, Flavia, Flammia, Rocco Simone, Anceschi, Umberto, Perdonà, Sisto, Franco, Giorgio, Sciarra, Alessandro, Di Pierro, Giovanni Battista, Cantisani, Vito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179124/
https://www.ncbi.nlm.nih.gov/pubmed/37176510
http://dx.doi.org/10.3390/jcm12093070
_version_ 1785041024155910144
author Tufano, Antonio
Leonardo, Costantino
Di Bella, Chiara
Lucarelli, Giuseppe
Dolcetti, Vincenzo
Dipinto, Piervito
Proietti, Flavia
Flammia, Rocco Simone
Anceschi, Umberto
Perdonà, Sisto
Franco, Giorgio
Sciarra, Alessandro
Di Pierro, Giovanni Battista
Cantisani, Vito
author_facet Tufano, Antonio
Leonardo, Costantino
Di Bella, Chiara
Lucarelli, Giuseppe
Dolcetti, Vincenzo
Dipinto, Piervito
Proietti, Flavia
Flammia, Rocco Simone
Anceschi, Umberto
Perdonà, Sisto
Franco, Giorgio
Sciarra, Alessandro
Di Pierro, Giovanni Battista
Cantisani, Vito
author_sort Tufano, Antonio
collection PubMed
description Background: We aimed to assess whether clear cell renal cell carcinoma (ccRCC) can be differentiated from renal oncocytoma (RO) on a contrast-enhanced ultrasound (CEUS). Methods: Between January 2021 and October 2022, we retrospectively queried and analyzed our prospectively maintained dataset. Renal mass features were scrutinized with conventional ultrasound imaging (CUS) and CEUS. All lesions were confirmed by histopathologic diagnoses after nephron-sparing surgery (NSS). A multivariable analysis was performed to identify the potential predictors of ccRCC. The area under the curve (AUC) was depicted in order to assess the diagnostic accuracy of the multivariable model. Results: A total of 126 renal masses, including 103 (81.7%) ccRCC and 23 (18.3%) RO, matched our inclusion criteria. Among these two groups, we found significant differences in terms of enhancement (homogeneous vs. heterogeneous) (p < 0.001), wash-in (fast vs. synchronous/slow) (p = 0.004), wash-out (fast vs. synchronous/slow) (p = 0.001), and rim-like enhancement (p < 0.001). On the multivariate logistic regression, heterogeneous enhancement (OR: 19.37; p = <0.001) and rim-like enhancement (OR: 3.73; p = 0.049) were independent predictors of ccRCC. Finally, these two variables had an AUC of 82.5% and 75.3%, respectively. Conclusions: Diagnostic imaging for presurgical planning is crucial in the choice of either conservative or radical management. CEUS, with its unique features, revealed its usefulness in differentiating ccRCC from RO.
format Online
Article
Text
id pubmed-10179124
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-101791242023-05-13 Qualitative Assessment of Contrast-Enhanced Ultrasound in Differentiating Clear Cell Renal Cell Carcinoma and Oncocytoma Tufano, Antonio Leonardo, Costantino Di Bella, Chiara Lucarelli, Giuseppe Dolcetti, Vincenzo Dipinto, Piervito Proietti, Flavia Flammia, Rocco Simone Anceschi, Umberto Perdonà, Sisto Franco, Giorgio Sciarra, Alessandro Di Pierro, Giovanni Battista Cantisani, Vito J Clin Med Brief Report Background: We aimed to assess whether clear cell renal cell carcinoma (ccRCC) can be differentiated from renal oncocytoma (RO) on a contrast-enhanced ultrasound (CEUS). Methods: Between January 2021 and October 2022, we retrospectively queried and analyzed our prospectively maintained dataset. Renal mass features were scrutinized with conventional ultrasound imaging (CUS) and CEUS. All lesions were confirmed by histopathologic diagnoses after nephron-sparing surgery (NSS). A multivariable analysis was performed to identify the potential predictors of ccRCC. The area under the curve (AUC) was depicted in order to assess the diagnostic accuracy of the multivariable model. Results: A total of 126 renal masses, including 103 (81.7%) ccRCC and 23 (18.3%) RO, matched our inclusion criteria. Among these two groups, we found significant differences in terms of enhancement (homogeneous vs. heterogeneous) (p < 0.001), wash-in (fast vs. synchronous/slow) (p = 0.004), wash-out (fast vs. synchronous/slow) (p = 0.001), and rim-like enhancement (p < 0.001). On the multivariate logistic regression, heterogeneous enhancement (OR: 19.37; p = <0.001) and rim-like enhancement (OR: 3.73; p = 0.049) were independent predictors of ccRCC. Finally, these two variables had an AUC of 82.5% and 75.3%, respectively. Conclusions: Diagnostic imaging for presurgical planning is crucial in the choice of either conservative or radical management. CEUS, with its unique features, revealed its usefulness in differentiating ccRCC from RO. MDPI 2023-04-23 /pmc/articles/PMC10179124/ /pubmed/37176510 http://dx.doi.org/10.3390/jcm12093070 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Tufano, Antonio
Leonardo, Costantino
Di Bella, Chiara
Lucarelli, Giuseppe
Dolcetti, Vincenzo
Dipinto, Piervito
Proietti, Flavia
Flammia, Rocco Simone
Anceschi, Umberto
Perdonà, Sisto
Franco, Giorgio
Sciarra, Alessandro
Di Pierro, Giovanni Battista
Cantisani, Vito
Qualitative Assessment of Contrast-Enhanced Ultrasound in Differentiating Clear Cell Renal Cell Carcinoma and Oncocytoma
title Qualitative Assessment of Contrast-Enhanced Ultrasound in Differentiating Clear Cell Renal Cell Carcinoma and Oncocytoma
title_full Qualitative Assessment of Contrast-Enhanced Ultrasound in Differentiating Clear Cell Renal Cell Carcinoma and Oncocytoma
title_fullStr Qualitative Assessment of Contrast-Enhanced Ultrasound in Differentiating Clear Cell Renal Cell Carcinoma and Oncocytoma
title_full_unstemmed Qualitative Assessment of Contrast-Enhanced Ultrasound in Differentiating Clear Cell Renal Cell Carcinoma and Oncocytoma
title_short Qualitative Assessment of Contrast-Enhanced Ultrasound in Differentiating Clear Cell Renal Cell Carcinoma and Oncocytoma
title_sort qualitative assessment of contrast-enhanced ultrasound in differentiating clear cell renal cell carcinoma and oncocytoma
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179124/
https://www.ncbi.nlm.nih.gov/pubmed/37176510
http://dx.doi.org/10.3390/jcm12093070
work_keys_str_mv AT tufanoantonio qualitativeassessmentofcontrastenhancedultrasoundindifferentiatingclearcellrenalcellcarcinomaandoncocytoma
AT leonardocostantino qualitativeassessmentofcontrastenhancedultrasoundindifferentiatingclearcellrenalcellcarcinomaandoncocytoma
AT dibellachiara qualitativeassessmentofcontrastenhancedultrasoundindifferentiatingclearcellrenalcellcarcinomaandoncocytoma
AT lucarelligiuseppe qualitativeassessmentofcontrastenhancedultrasoundindifferentiatingclearcellrenalcellcarcinomaandoncocytoma
AT dolcettivincenzo qualitativeassessmentofcontrastenhancedultrasoundindifferentiatingclearcellrenalcellcarcinomaandoncocytoma
AT dipintopiervito qualitativeassessmentofcontrastenhancedultrasoundindifferentiatingclearcellrenalcellcarcinomaandoncocytoma
AT proiettiflavia qualitativeassessmentofcontrastenhancedultrasoundindifferentiatingclearcellrenalcellcarcinomaandoncocytoma
AT flammiaroccosimone qualitativeassessmentofcontrastenhancedultrasoundindifferentiatingclearcellrenalcellcarcinomaandoncocytoma
AT anceschiumberto qualitativeassessmentofcontrastenhancedultrasoundindifferentiatingclearcellrenalcellcarcinomaandoncocytoma
AT perdonasisto qualitativeassessmentofcontrastenhancedultrasoundindifferentiatingclearcellrenalcellcarcinomaandoncocytoma
AT francogiorgio qualitativeassessmentofcontrastenhancedultrasoundindifferentiatingclearcellrenalcellcarcinomaandoncocytoma
AT sciarraalessandro qualitativeassessmentofcontrastenhancedultrasoundindifferentiatingclearcellrenalcellcarcinomaandoncocytoma
AT dipierrogiovannibattista qualitativeassessmentofcontrastenhancedultrasoundindifferentiatingclearcellrenalcellcarcinomaandoncocytoma
AT cantisanivito qualitativeassessmentofcontrastenhancedultrasoundindifferentiatingclearcellrenalcellcarcinomaandoncocytoma