Cargando…

Uremic Toxin Indoxyl Sulfate Promotes Macrophage-Associated Low-Grade Inflammation and Epithelial Cell Senescence

In this study, we investigated the impact of the uremic toxin indoxyl sulfate on macrophages and tubular epithelial cells and its role in modulating the response to lipopolysaccharide (LPS). Indoxyl sulfate accumulates in the blood of patients with chronic kidney disease (CKD) and is a predictor of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ribeiro, Andrea, Liu, Feiyue, Srebrzynski, Matthias, Rother, Simone, Adamowicz, Karina, Wadowska, Marta, Steiger, Stefanie, Anders, Hans-Joachim, Schmaderer, Christoph, Koziel, Joanna, Lech, Maciej
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179130/ https://www.ncbi.nlm.nih.gov/pubmed/37175735 http://dx.doi.org/10.3390/ijms24098031

Ejemplares similares

Binding Affinity and Capacity for the Uremic Toxin Indoxyl Sulfate
por: Devine, Eric, et al.
Publicado: (2014)

The Uremic Toxin Indoxyl Sulfate Accelerates Senescence in Kidney Proximal Tubule Cells
por: Yang, Yi, et al.
Publicado: (2023)

Triggering of suicidal erythrocyte death by uremic toxin indoxyl sulfate
por: Ahmed, Mohamed Siyabeldin E, et al.
Publicado: (2013)

Neurobehavioral effects of uremic toxin–indoxyl sulfate in the rat model
por: Karbowska, Malgorzata, et al.
Publicado: (2020)

Indoxyl Sulfate, a Uremic Endotheliotoxin
por: Lano, Guillaume, et al.
Publicado: (2020)

Effects of Sevelamer Hydrochloride on Uremic Toxins Serum Indoxyl Sulfate and P-Cresyl Sulfate in Hemodialysis Patients
por: Lin, Cheng-Jui, et al.
Publicado: (2017)

Uremic Toxin Indoxyl Sulfate Impairs Hydrogen Sulfide Formation in Renal Tubular Cells
por: Lu, Chien-Lin, et al.
Publicado: (2022)

SLC22A11 Inserts the Uremic Toxins Indoxyl Sulfate and P-Cresol Sulfate into the Plasma Membrane
por: Tust, Maurice, et al.
Publicado: (2023)

Podocyte Injury Caused by Indoxyl Sulfate, a Uremic Toxin and Aryl-Hydrocarbon Receptor Ligand
por: Ichii, Osamu, et al.
Publicado: (2014)

The Uremic Toxin Indoxyl Sulfate Accelerates Thrombotic Response after Vascular Injury in Animal Models
por: Karbowska, Malgorzata, et al.
Publicado: (2017)

TRPV1 Hyperfunction Involved in Uremic Toxin Indoxyl Sulfate-Mediated Renal Tubular Damage
por: Lu, Chien-Lin, et al.
Publicado: (2020)

Macrophage-Specific MCPIP1/Regnase-1 Attenuates Kidney Ischemia-Reperfusion Injury by Shaping the Local Inflammatory Response and Tissue Regeneration
por: Ribeiro, Andrea, et al.
Publicado: (2022)

Uremic toxin indoxyl sulfate promotes proinflammatory macrophage activation by regulation of β-catenin and YAP pathways
por: Li, Ying, et al.
Publicado: (2021)

Gut-Derived Uremic Toxins in CKD: An Improved Approach for the Evaluation of Serum Indoxyl Sulfate in Clinical Practice
por: Caggiano, Gianvito, et al.
Publicado: (2023)

The Uremic Toxin Indoxyl Sulphate Enhances Macrophage Response to LPS
por: Adesso, Simona, et al.
Publicado: (2013)

Indoxyl sulfate, a uremic toxin in chronic kidney disease, suppresses both bone formation and bone resorption
por: Watanabe, Kenta, et al.
Publicado: (2017)

Effects of the uremic toxin indoxyl sulphate on human microvascular endothelial cells
por: Colombo, Graziano, et al.
Publicado: (2022)

Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB
por: Bolati, Dilinaer, et al.
Publicado: (2013)

Indoxyl sulfate – the uremic toxin linking hemostatic system disturbances with the prevalence of cardiovascular disease in patients with chronic kidney disease
por: Kamiński, Tomasz W., et al.
Publicado: (2017)

Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression
por: Takada, T., et al.
Publicado: (2018)

Functional Genomic Analysis Identifies Indoxyl Sulfate as a Major, Poorly Dialyzable Uremic Toxin in End-Stage Renal Disease
por: Jhawar, Sachin, et al.
Publicado: (2015)

Possible Effects of Uremic Toxins p-Cresol, Indoxyl Sulfate, p-Cresyl Sulfate on the Development and Progression of Colon Cancer in Patients with Chronic Renal Failure
por: Di Paola, Rossella, et al.
Publicado: (2023)

Chronic Kidney Disease-Induced Cardiac Fibrosis Is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uremic Toxin, Indoxyl Sulfate
por: Lekawanvijit, Suree, et al.
Publicado: (2012)

The impact of antihypertensive pharmacotherapy on interplay between protein-bound uremic toxin (indoxyl sulfate) and markers of inflammation in patients with chronic kidney disease
por: Kaminski, Tomasz W., et al.
Publicado: (2019)

Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease
por: Sato, Emiko, et al.
Publicado: (2016)

Lactobacillus salivarius BP121 prevents cisplatin-induced acute kidney injury by inhibition of uremic toxins such as indoxyl sulfate and p-cresol sulfate via alleviating dysbiosis
por: Lee, Tae-Hee, et al.
Publicado: (2020)

Uremic Retention Solute Indoxyl Sulfate Level Is Associated with Prolonged QTc Interval in Early CKD Patients
por: Tang, Wei-Hua, et al.
Publicado: (2015)

Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature
por: Brydges, Christopher R., et al.
Publicado: (2021)

Indoxyl Sulfate, a Tubular Toxin, Contributes to the Development of Chronic Kidney Disease
por: Cheng, Tong-Hong, et al.
Publicado: (2020)

Comment on Indoxyl Sulfate—Review of Toxicity and Therapeutic Strategies. Toxins 2016, 8, 358
por: Barreto, Fellype C., et al.
Publicado: (2017)

P-cresol and Indoxyl Sulfate Impair Osteogenic Differentiation by Triggering Mesenchymal Stem Cell Senescence
por: Kamprom, Witchayapon, et al.
Publicado: (2021)

The role of AMP‐activated protein kinase α1‐mediated endoplasmic reticulum stress in alleviating the toxic effect of uremic toxin indoxyl sulfate on vascular endothelial cells by Klotho
por: Chen, Cheng, et al.
Publicado: (2021)

Protein-Bound Uremic Toxins in Senescence and Kidney Fibrosis
por: Yang, Yi, et al.
Publicado: (2023)

Indoxyl Sulfate—Review of Toxicity and Therapeutic Strategies
por: Leong, Sheldon C., et al.
Publicado: (2016)

Indoxyl sulfate impairs valsartan-induced neovascularization()
por: Kuo, Ko-Lin, et al.
Publicado: (2020)

Toxic Effects of Indoxyl Sulfate on Osteoclastogenesis and Osteoblastogenesis
por: Shyu, Jia-Fwu, et al.
Publicado: (2021)

Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation
por: Dobosz, Ewelina, et al.
Publicado: (2021)

p-Cresyl sulfate and indoxyl sulfate in pediatric patients on chronic dialysis
por: Hyun, Hye Sun, et al.
Publicado: (2013)

Aristolochic acid I determine the phenotype and activation of macrophages in acute and chronic kidney disease
por: Honarpisheh, Mohsen, et al.
Publicado: (2018)

Indoxyl sulfate promotes apoptosis in cultured osteoblast cells
por: Kim, Young-Hee, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_bighlh8bi6faceajsgmet37e7m