Endotheliopathy in Acute COVID-19 and Long COVID

The pulmonary endothelium is a highly regulated organ that performs a wide range of functions under physiological and pathological conditions. Since endothelial dysfunction has been demonstrated to play a direct role in sepsis and acute respiratory distress syndrome, its role in COVID-19 has also be...

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Autores principales: Vassiliou, Alice G., Vrettou, Charikleia S., Keskinidou, Chrysi, Dimopoulou, Ioanna, Kotanidou, Anastasia, Orfanos, Stylianos E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179170/
https://www.ncbi.nlm.nih.gov/pubmed/37175942
http://dx.doi.org/10.3390/ijms24098237
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author Vassiliou, Alice G.
Vrettou, Charikleia S.
Keskinidou, Chrysi
Dimopoulou, Ioanna
Kotanidou, Anastasia
Orfanos, Stylianos E.
author_facet Vassiliou, Alice G.
Vrettou, Charikleia S.
Keskinidou, Chrysi
Dimopoulou, Ioanna
Kotanidou, Anastasia
Orfanos, Stylianos E.
author_sort Vassiliou, Alice G.
collection PubMed
description The pulmonary endothelium is a highly regulated organ that performs a wide range of functions under physiological and pathological conditions. Since endothelial dysfunction has been demonstrated to play a direct role in sepsis and acute respiratory distress syndrome, its role in COVID-19 has also been extensively investigated. Indeed, apart from the COVID-19-associated coagulopathy biomarkers, new biomarkers were recognised early during the pandemic, including markers of endothelial cell activation or injury. We systematically searched the literature up to 10 March 2023 for studies examining the association between acute and long COVID-19 severity and outcomes and endothelial biomarkers.
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spelling pubmed-101791702023-05-13 Endotheliopathy in Acute COVID-19 and Long COVID Vassiliou, Alice G. Vrettou, Charikleia S. Keskinidou, Chrysi Dimopoulou, Ioanna Kotanidou, Anastasia Orfanos, Stylianos E. Int J Mol Sci Review The pulmonary endothelium is a highly regulated organ that performs a wide range of functions under physiological and pathological conditions. Since endothelial dysfunction has been demonstrated to play a direct role in sepsis and acute respiratory distress syndrome, its role in COVID-19 has also been extensively investigated. Indeed, apart from the COVID-19-associated coagulopathy biomarkers, new biomarkers were recognised early during the pandemic, including markers of endothelial cell activation or injury. We systematically searched the literature up to 10 March 2023 for studies examining the association between acute and long COVID-19 severity and outcomes and endothelial biomarkers. MDPI 2023-05-04 /pmc/articles/PMC10179170/ /pubmed/37175942 http://dx.doi.org/10.3390/ijms24098237 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vassiliou, Alice G.
Vrettou, Charikleia S.
Keskinidou, Chrysi
Dimopoulou, Ioanna
Kotanidou, Anastasia
Orfanos, Stylianos E.
Endotheliopathy in Acute COVID-19 and Long COVID
title Endotheliopathy in Acute COVID-19 and Long COVID
title_full Endotheliopathy in Acute COVID-19 and Long COVID
title_fullStr Endotheliopathy in Acute COVID-19 and Long COVID
title_full_unstemmed Endotheliopathy in Acute COVID-19 and Long COVID
title_short Endotheliopathy in Acute COVID-19 and Long COVID
title_sort endotheliopathy in acute covid-19 and long covid
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179170/
https://www.ncbi.nlm.nih.gov/pubmed/37175942
http://dx.doi.org/10.3390/ijms24098237
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