Cargando…

Long-Term Efficacy and Safety of Risankizumab for Moderate to Severe Psoriasis: A 2-Year Real-Life Retrospective Study

Risankizumab is a humanized IgG monoclonal antibody inhibitor of IL23 and has been recently approved by the EMA and the FDA for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy. Its efficacy and safety have been reported by clinical trials and re...

Descripción completa

Detalles Bibliográficos
Autores principales: Megna, Matteo, Ruggiero, Angelo, Battista, Teresa, Marano, Laura, Cacciapuoti, Sara, Potestio, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179221/
https://www.ncbi.nlm.nih.gov/pubmed/37176672
http://dx.doi.org/10.3390/jcm12093233
_version_ 1785041046480093184
author Megna, Matteo
Ruggiero, Angelo
Battista, Teresa
Marano, Laura
Cacciapuoti, Sara
Potestio, Luca
author_facet Megna, Matteo
Ruggiero, Angelo
Battista, Teresa
Marano, Laura
Cacciapuoti, Sara
Potestio, Luca
author_sort Megna, Matteo
collection PubMed
description Risankizumab is a humanized IgG monoclonal antibody inhibitor of IL23 and has been recently approved by the EMA and the FDA for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy. Its efficacy and safety have been reported by clinical trials and real-life studies. However, even if long-term data from trials have already been reported (up to 172 weeks), data on long-term real-life experiences are still limited. The aim of our study was to investigate the long-term (2 years) efficacy and safety of risankizumab for psoriasis management in a real-life setting. A monocentric retrospective study was performed, enrolling 168 patients affected by moderate to severe psoriasis who were undergoing treatment with risankizumab. Psoriasis severity and safety outcomes were evaluated at each follow-up visit (week 16, week 28, week 52, week 88, week 104). A statistically significant reduction of psoriasis severity scores was reported from week 16 and was maintained up to week 104. Moreover, interesting results in terms of safety have been collected, without any serious adverse events registered. Our long-term real-life monocentric retrospective study confirmed the efficacy and safety of risankizumab up to 104 weeks of treatment. However, further studies are required to confirm our results and to increase available data to establish the best evidence-based biologic selection algorithm.
format Online
Article
Text
id pubmed-10179221
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-101792212023-05-13 Long-Term Efficacy and Safety of Risankizumab for Moderate to Severe Psoriasis: A 2-Year Real-Life Retrospective Study Megna, Matteo Ruggiero, Angelo Battista, Teresa Marano, Laura Cacciapuoti, Sara Potestio, Luca J Clin Med Article Risankizumab is a humanized IgG monoclonal antibody inhibitor of IL23 and has been recently approved by the EMA and the FDA for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy. Its efficacy and safety have been reported by clinical trials and real-life studies. However, even if long-term data from trials have already been reported (up to 172 weeks), data on long-term real-life experiences are still limited. The aim of our study was to investigate the long-term (2 years) efficacy and safety of risankizumab for psoriasis management in a real-life setting. A monocentric retrospective study was performed, enrolling 168 patients affected by moderate to severe psoriasis who were undergoing treatment with risankizumab. Psoriasis severity and safety outcomes were evaluated at each follow-up visit (week 16, week 28, week 52, week 88, week 104). A statistically significant reduction of psoriasis severity scores was reported from week 16 and was maintained up to week 104. Moreover, interesting results in terms of safety have been collected, without any serious adverse events registered. Our long-term real-life monocentric retrospective study confirmed the efficacy and safety of risankizumab up to 104 weeks of treatment. However, further studies are required to confirm our results and to increase available data to establish the best evidence-based biologic selection algorithm. MDPI 2023-04-30 /pmc/articles/PMC10179221/ /pubmed/37176672 http://dx.doi.org/10.3390/jcm12093233 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Megna, Matteo
Ruggiero, Angelo
Battista, Teresa
Marano, Laura
Cacciapuoti, Sara
Potestio, Luca
Long-Term Efficacy and Safety of Risankizumab for Moderate to Severe Psoriasis: A 2-Year Real-Life Retrospective Study
title Long-Term Efficacy and Safety of Risankizumab for Moderate to Severe Psoriasis: A 2-Year Real-Life Retrospective Study
title_full Long-Term Efficacy and Safety of Risankizumab for Moderate to Severe Psoriasis: A 2-Year Real-Life Retrospective Study
title_fullStr Long-Term Efficacy and Safety of Risankizumab for Moderate to Severe Psoriasis: A 2-Year Real-Life Retrospective Study
title_full_unstemmed Long-Term Efficacy and Safety of Risankizumab for Moderate to Severe Psoriasis: A 2-Year Real-Life Retrospective Study
title_short Long-Term Efficacy and Safety of Risankizumab for Moderate to Severe Psoriasis: A 2-Year Real-Life Retrospective Study
title_sort long-term efficacy and safety of risankizumab for moderate to severe psoriasis: a 2-year real-life retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179221/
https://www.ncbi.nlm.nih.gov/pubmed/37176672
http://dx.doi.org/10.3390/jcm12093233
work_keys_str_mv AT megnamatteo longtermefficacyandsafetyofrisankizumabformoderatetoseverepsoriasisa2yearrealliferetrospectivestudy
AT ruggieroangelo longtermefficacyandsafetyofrisankizumabformoderatetoseverepsoriasisa2yearrealliferetrospectivestudy
AT battistateresa longtermefficacyandsafetyofrisankizumabformoderatetoseverepsoriasisa2yearrealliferetrospectivestudy
AT maranolaura longtermefficacyandsafetyofrisankizumabformoderatetoseverepsoriasisa2yearrealliferetrospectivestudy
AT cacciapuotisara longtermefficacyandsafetyofrisankizumabformoderatetoseverepsoriasisa2yearrealliferetrospectivestudy
AT potestioluca longtermefficacyandsafetyofrisankizumabformoderatetoseverepsoriasisa2yearrealliferetrospectivestudy