The Prohibitin-Binding Compound Fluorizoline Activates the Integrated Stress Response through the eIF2α Kinase HRI

Fluorizoline is a synthetic molecule that induces apoptosis, by selectively targeting prohibitins (PHBs), through induction of the BH3-only protein NOXA. This induction is transcriptionally regulated by the integrated stress response (ISR)-related transcription factors ATF3 and ATF4. Here, we evalua...

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Detalles Bibliográficos
Autores principales: Sánchez-Vera, Ismael, Núñez-Vázquez, Sonia, Saura-Esteller, José, Cosialls, Ana M., Heib, Judith, Nadal Rodríguez, Pau, Ghashghaei, Ouldouz, Lavilla, Rodolfo, Pons, Gabriel, Gil, Joan, Iglesias-Serret, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179266/
https://www.ncbi.nlm.nih.gov/pubmed/37175767
http://dx.doi.org/10.3390/ijms24098064

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