Cargando…

Induction of Inflammation Disrupts the Negative Interplay between STING and S1P Axis That Is Observed during Physiological Conditions in the Lung

The stimulator of interferon genes (STING) is a master regulator of innate immunity, involved in several inflammatory diseases. Our previous data showed that sphingosine-1-phosphate (S1P) is released during inflammatory conditions in the lung. The aim of this study was to understand the interplay be...

Descripción completa

Detalles Bibliográficos
Autores principales:	Terlizzi, Michela, Colarusso, Chiara, Falanga, Anna, Somma, Pasquale, De Rosa, Ilaria, Panico, Luigi, Pinto, Aldo, Maiolino, Piera, Sorrentino, Rosalinda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179278/ https://www.ncbi.nlm.nih.gov/pubmed/37176007 http://dx.doi.org/10.3390/ijms24098303

Ejemplares similares

Sex Differences in Sphingosine-1-Phosphate Levels Are Dependent on Ceramide Synthase 1 and Ceramidase in Lung Physiology and Tumor Conditions
por: Terlizzi, Michela, et al.
Publicado: (2023)

S1P-Induced TNF-α and IL-6 Release from PBMCs Exacerbates Lung Cancer-Associated Inflammation
por: Terlizzi, Michela, et al.
Publicado: (2022)

AIM2/IL-1α/TGF-β Axis in PBMCs From Exacerbated Chronic Obstructive Pulmonary Disease (COPD) Patients Is Not Related to COX-2-Dependent Inflammatory Pathway
por: Molino, Antonio, et al.
Publicado: (2019)

A lesson from a saboteur: High‐MW kininogen impact in coronavirus‐induced disease 2019
por: Colarusso, Chiara, et al.
Publicado: (2020)

Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients
por: Terlizzi, Michela, et al.
Publicado: (2020)

Altered lung tissue lipidomic profile in caspase-4 positive non-small cell lung cancer (NSCLC) patients
por: Terlizzi, Michela, et al.
Publicado: (2020)

IL-1α and IL-1β-producing macrophages populate lung tumor lesions in mice
por: Terlizzi, Michela, et al.
Publicado: (2016)

Role of the inflammasome in chronic obstructive pulmonary disease (COPD)
por: Colarusso, Chiara, et al.
Publicado: (2017)

AIM2 Inflammasome Activation Leads to IL-1α and TGF-β Release From Exacerbated Chronic Obstructive Pulmonary Disease-Derived Peripheral Blood Mononuclear Cells
por: Colarusso, Chiara, et al.
Publicado: (2019)

Activation of the Absent in Melanoma 2 Inflammasome in Peripheral Blood Mononuclear Cells From Idiopathic Pulmonary Fibrosis Patients Leads to the Release of Pro-Fibrotic Mediators
por: Terlizzi, Michela, et al.
Publicado: (2018)

Antioxidant and antimicrobial properties of Pelargonium sidoides DC and lactoferrin combination
por: Terlizzi, Michela, et al.
Publicado: (2020)

Post-COVID-19 Patients Who Develop Lung Fibrotic-like Changes Have Lower Circulating Levels of IFN-β but Higher Levels of IL-1α and TGF-β
por: Colarusso, Chiara, et al.
Publicado: (2021)

Correction: Circulating and tumor-associated caspase-4: a novel diagnostic and prognostic biomarker for non-small cell lung cancer
por: Terlizzi, Michela, et al.
Publicado: (2018)

Caspase-11 and AIM2 inflammasome are involved in smoking-induced COPD and lung adenocarcinoma
por: Colarusso, Chiara, et al.
Publicado: (2021)

Circulating and tumor-associated caspase-4: a novel diagnostic and prognostic biomarker for non-small cell lung cancer
por: Terlizzi, Michela, et al.
Publicado: (2018)

Activation of the AIM2 Receptor in Circulating Cells of Post-COVID-19 Patients With Signs of Lung Fibrosis Is Associated With the Release of IL-1α, IFN-α and TGF-β
por: Colarusso, Chiara, et al.
Publicado: (2022)

The Inhibition of Caspase-1- Does Not Revert Particulate Matter (PM)-Induced Lung Immunesuppression in Mice
por: Colarusso, Chiara, et al.
Publicado: (2019)

Chronic Obstructive Pulmonary Disease-Derived Circulating Cells Release IL-18 and IL-33 under Ultrafine Particulate Matter Exposure in a Caspase-1/8-Independent Manner
por: De Falco, Gianluigi, et al.
Publicado: (2017)

Interplay between RNA viruses and cGAS/STING axis in innate immunity
por: Amurri, Lucia, et al.
Publicado: (2023)

Human peripheral blood mononuclear cells (PBMCs) from smokers release higher levels of IL-1-like cytokines after exposure to combustion-generated ultrafine particles
por: De Falco, Gianluigi, et al.
Publicado: (2017)

Plasmacytoid Dendritic Cells: From Heart to Vessels
por: Sorrentino, Rosalinda, et al.
Publicado: (2010)

The adenosinergic system in cancer: Key therapeutic target
por: Sorrentino, Rosalinda, et al.
Publicado: (2013)

Toll-Like Receptor 4 Is Essential for the Expression of Sphingosine-1-Phosphate-Dependent Asthma-Like Disease in Mice
por: Roviezzo, Fiorentina, et al.
Publicado: (2017)

Plasmacytoid dendritic cells and their therapeutic activity in cancer
por: Pinto, Aldo, et al.
Publicado: (2012)

Sphingosine‐1‐phosphate/TGF‐β axis drives epithelial mesenchymal transition in asthma‐like disease
por: Riemma, Maria A., et al.
Publicado: (2022)

Feline Panleucopenia Virus NS2 Suppresses the Host IFN-β Induction by Disrupting the Interaction between TBK1 and STING
por: Kang, Hongtao, et al.
Publicado: (2017)

SV40 Large T Antigen Is Not Responsible for the Loss of STING in 293T Cells but Can Inhibit cGAS-STING Interferon Induction
por: Reus, Joshua B., et al.
Publicado: (2020)

Regulation and function of the cGAS-MITA/STING axis in health and disease
por: Zhang, Zhi-Dong, et al.
Publicado: (2022)

Radiation Induces Bone Microenvironment Disruption by Activating the STING-TBK1 Pathway
por: Wang, Yuyang, et al.
Publicado: (2023)

The Uremic Toxin Indoxyl Sulphate Enhances Macrophage Response to LPS
por: Adesso, Simona, et al.
Publicado: (2013)

Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability
por: Movert, Elin, et al.
Publicado: (2023)

Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy
por: Zheng, Juyan, et al.
Publicado: (2020)

Interplay of membrane crosslinking and curvature induction by annexins
por: Mularski, Anna, et al.
Publicado: (2022)

Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour
por: Jeong, Seung-hwan, et al.
Publicado: (2021)

Sting /
por: Leduc, Jean-Marie
Publicado: (1992)

Both STING and MAVS Fish Orthologs Contribute to the Induction of Interferon Mediated by RIG-I
por: Biacchesi, Stéphane, et al.
Publicado: (2012)

Autophagy Induction via STING Trafficking Is a Primordial Function of the cGAS Pathway
por: Gui, Xiang, et al.
Publicado: (2019)

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death
por: Wu, Jianjun, et al.
Publicado: (2019)

Interplay of Plasmodium falciparum and thrombin in brain endothelial barrier disruption
por: Avril, Marion, et al.
Publicado: (2019)

The STING-IFN-β-Dependent Axis Is Markedly Low in Patients with Relapsing-Remitting Multiple Sclerosis
por: Masanneck, Lars, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_l502bfv0m8m52ujs9d7o2eh48u