In Silico Design of New Dual Inhibitors of SARS-CoV-2 M(PRO) through Ligand- and Structure-Based Methods

The viral main protease is one of the most attractive targets among all key enzymes involved in the life cycle of SARS-CoV-2. Considering its mechanism of action, both the catalytic and dimerization regions could represent crucial sites for modulating its activity. Dual-binding the SARS-CoV-2 main p...

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Detalles Bibliográficos
Autores principales: Bono, Alessia, Lauria, Antonino, La Monica, Gabriele, Alamia, Federica, Mingoia, Francesco, Martorana, Annamaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179319/
https://www.ncbi.nlm.nih.gov/pubmed/37176082
http://dx.doi.org/10.3390/ijms24098377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179319/
https://www.ncbi.nlm.nih.gov/pubmed/37176082
http://dx.doi.org/10.3390/ijms24098377

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