Cargando…
Impact of High-Intensity Statin on Early Neurologic Deterioration in Patients with Single Small Subcortical Infarction
Backgrounds: One of the major hypotheses for early neurological deterioration (END) in single small subcortical infarction (SSSI) is the process of atherosclerosis. However, the association between statin therapy, especially high-intensity statin therapy, and its effectiveness in reducing the incide...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179331/ https://www.ncbi.nlm.nih.gov/pubmed/37176701 http://dx.doi.org/10.3390/jcm12093260 |
_version_ | 1785041072626335744 |
---|---|
author | Jang, Seong Hwa Park, Hyungjong Hong, Jeong-Ho Yoo, Joonsang Lee, Hyung Kim, Hyun Ah Sohn, Sung-Il |
author_facet | Jang, Seong Hwa Park, Hyungjong Hong, Jeong-Ho Yoo, Joonsang Lee, Hyung Kim, Hyun Ah Sohn, Sung-Il |
author_sort | Jang, Seong Hwa |
collection | PubMed |
description | Backgrounds: One of the major hypotheses for early neurological deterioration (END) in single small subcortical infarction (SSSI) is the process of atherosclerosis. However, the association between statin therapy, especially high-intensity statin therapy, and its effectiveness in reducing the incidence of END during the acute phase of SSSI remains unclear. This study aimed to investigate the influence of high-intensity statin therapy compared to moderate-intensity statin therapy during the acute phase on the incidence of END in SSSI. Methods: The records of 492 patients with SSSI who received statin therapy within 72 h of symptom onset from a prospective stroke registry were analyzed. The association between END and statin intensity was evaluated using multivariable regression analysis for adjusted odds ratio (aOR). Results: Of the 492 patients with SSSI (mean age: 67.2 years, median NIHSS score on admission: 3), END occurred in 102 (20.7%). Older age (aOR, 1.02; 95% confidence interval (CI), 1.00–1.05; p = 0.017), and branch atheromatous lesion (aOR, 3.49; 95% CI 2.16–5.74; p < 0.001) were associated with END. Early high-intensity statin therapy was associated with a lower incidence of END than moderate-intensity statin therapy (aOR, 0.44; 95% CI, 0.25–0.77; p = 0.004). In addition, there was significantly lower incidence of END in early administration (≤24 h) of high-intensity statin group. Conclusions: We identified an association between the intensity of early statin therapy and END in patients with SSSI. Early administration of high-intensity statin (≤24 h) is associated with a reduced incidence of END in patients with SSSI. |
format | Online Article Text |
id | pubmed-10179331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101793312023-05-13 Impact of High-Intensity Statin on Early Neurologic Deterioration in Patients with Single Small Subcortical Infarction Jang, Seong Hwa Park, Hyungjong Hong, Jeong-Ho Yoo, Joonsang Lee, Hyung Kim, Hyun Ah Sohn, Sung-Il J Clin Med Article Backgrounds: One of the major hypotheses for early neurological deterioration (END) in single small subcortical infarction (SSSI) is the process of atherosclerosis. However, the association between statin therapy, especially high-intensity statin therapy, and its effectiveness in reducing the incidence of END during the acute phase of SSSI remains unclear. This study aimed to investigate the influence of high-intensity statin therapy compared to moderate-intensity statin therapy during the acute phase on the incidence of END in SSSI. Methods: The records of 492 patients with SSSI who received statin therapy within 72 h of symptom onset from a prospective stroke registry were analyzed. The association between END and statin intensity was evaluated using multivariable regression analysis for adjusted odds ratio (aOR). Results: Of the 492 patients with SSSI (mean age: 67.2 years, median NIHSS score on admission: 3), END occurred in 102 (20.7%). Older age (aOR, 1.02; 95% confidence interval (CI), 1.00–1.05; p = 0.017), and branch atheromatous lesion (aOR, 3.49; 95% CI 2.16–5.74; p < 0.001) were associated with END. Early high-intensity statin therapy was associated with a lower incidence of END than moderate-intensity statin therapy (aOR, 0.44; 95% CI, 0.25–0.77; p = 0.004). In addition, there was significantly lower incidence of END in early administration (≤24 h) of high-intensity statin group. Conclusions: We identified an association between the intensity of early statin therapy and END in patients with SSSI. Early administration of high-intensity statin (≤24 h) is associated with a reduced incidence of END in patients with SSSI. MDPI 2023-05-03 /pmc/articles/PMC10179331/ /pubmed/37176701 http://dx.doi.org/10.3390/jcm12093260 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jang, Seong Hwa Park, Hyungjong Hong, Jeong-Ho Yoo, Joonsang Lee, Hyung Kim, Hyun Ah Sohn, Sung-Il Impact of High-Intensity Statin on Early Neurologic Deterioration in Patients with Single Small Subcortical Infarction |
title | Impact of High-Intensity Statin on Early Neurologic Deterioration in Patients with Single Small Subcortical Infarction |
title_full | Impact of High-Intensity Statin on Early Neurologic Deterioration in Patients with Single Small Subcortical Infarction |
title_fullStr | Impact of High-Intensity Statin on Early Neurologic Deterioration in Patients with Single Small Subcortical Infarction |
title_full_unstemmed | Impact of High-Intensity Statin on Early Neurologic Deterioration in Patients with Single Small Subcortical Infarction |
title_short | Impact of High-Intensity Statin on Early Neurologic Deterioration in Patients with Single Small Subcortical Infarction |
title_sort | impact of high-intensity statin on early neurologic deterioration in patients with single small subcortical infarction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179331/ https://www.ncbi.nlm.nih.gov/pubmed/37176701 http://dx.doi.org/10.3390/jcm12093260 |
work_keys_str_mv | AT jangseonghwa impactofhighintensitystatinonearlyneurologicdeteriorationinpatientswithsinglesmallsubcorticalinfarction AT parkhyungjong impactofhighintensitystatinonearlyneurologicdeteriorationinpatientswithsinglesmallsubcorticalinfarction AT hongjeongho impactofhighintensitystatinonearlyneurologicdeteriorationinpatientswithsinglesmallsubcorticalinfarction AT yoojoonsang impactofhighintensitystatinonearlyneurologicdeteriorationinpatientswithsinglesmallsubcorticalinfarction AT leehyung impactofhighintensitystatinonearlyneurologicdeteriorationinpatientswithsinglesmallsubcorticalinfarction AT kimhyunah impactofhighintensitystatinonearlyneurologicdeteriorationinpatientswithsinglesmallsubcorticalinfarction AT sohnsungil impactofhighintensitystatinonearlyneurologicdeteriorationinpatientswithsinglesmallsubcorticalinfarction |