Cargando…

Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions

It has been widely demonstrated that the gut microbiota is responsible for essential functions in human health and that its perturbation is implicated in the development and progression of a growing list of diseases. The number of studies evaluating how the gut microbiota interacts with and influenc...

Descripción completa

Detalles Bibliográficos
Autores principales: Calabrò, Sonia, Kankowski, Svenja, Cescon, Matilde, Gambarotta, Giovanna, Raimondo, Stefania, Haastert-Talini, Kirsten, Ronchi, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179357/
https://www.ncbi.nlm.nih.gov/pubmed/37175764
http://dx.doi.org/10.3390/ijms24098061
_version_ 1785041078818177024
author Calabrò, Sonia
Kankowski, Svenja
Cescon, Matilde
Gambarotta, Giovanna
Raimondo, Stefania
Haastert-Talini, Kirsten
Ronchi, Giulia
author_facet Calabrò, Sonia
Kankowski, Svenja
Cescon, Matilde
Gambarotta, Giovanna
Raimondo, Stefania
Haastert-Talini, Kirsten
Ronchi, Giulia
author_sort Calabrò, Sonia
collection PubMed
description It has been widely demonstrated that the gut microbiota is responsible for essential functions in human health and that its perturbation is implicated in the development and progression of a growing list of diseases. The number of studies evaluating how the gut microbiota interacts with and influences other organs and systems in the body and vice versa is constantly increasing and several ‘gut–organ axes’ have already been defined. Recently, the view on the link between the gut microbiota (GM) and the peripheral nervous system (PNS) has become broader by exceeding the fact that the PNS can serve as a systemic carrier of GM-derived metabolites and products to other organs. The PNS as the communication network between the central nervous system and the periphery of the body and internal organs can rather be affected itself by GM perturbation. In this review, we summarize the current knowledge about the impact of gut microbiota on the PNS, with regard to its somatic and autonomic divisions, in physiological, regenerative and pathological conditions.
format Online
Article
Text
id pubmed-10179357
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-101793572023-05-13 Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions Calabrò, Sonia Kankowski, Svenja Cescon, Matilde Gambarotta, Giovanna Raimondo, Stefania Haastert-Talini, Kirsten Ronchi, Giulia Int J Mol Sci Review It has been widely demonstrated that the gut microbiota is responsible for essential functions in human health and that its perturbation is implicated in the development and progression of a growing list of diseases. The number of studies evaluating how the gut microbiota interacts with and influences other organs and systems in the body and vice versa is constantly increasing and several ‘gut–organ axes’ have already been defined. Recently, the view on the link between the gut microbiota (GM) and the peripheral nervous system (PNS) has become broader by exceeding the fact that the PNS can serve as a systemic carrier of GM-derived metabolites and products to other organs. The PNS as the communication network between the central nervous system and the periphery of the body and internal organs can rather be affected itself by GM perturbation. In this review, we summarize the current knowledge about the impact of gut microbiota on the PNS, with regard to its somatic and autonomic divisions, in physiological, regenerative and pathological conditions. MDPI 2023-04-29 /pmc/articles/PMC10179357/ /pubmed/37175764 http://dx.doi.org/10.3390/ijms24098061 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Calabrò, Sonia
Kankowski, Svenja
Cescon, Matilde
Gambarotta, Giovanna
Raimondo, Stefania
Haastert-Talini, Kirsten
Ronchi, Giulia
Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions
title Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions
title_full Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions
title_fullStr Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions
title_full_unstemmed Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions
title_short Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions
title_sort impact of gut microbiota on the peripheral nervous system in physiological, regenerative and pathological conditions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179357/
https://www.ncbi.nlm.nih.gov/pubmed/37175764
http://dx.doi.org/10.3390/ijms24098061
work_keys_str_mv AT calabrosonia impactofgutmicrobiotaontheperipheralnervoussysteminphysiologicalregenerativeandpathologicalconditions
AT kankowskisvenja impactofgutmicrobiotaontheperipheralnervoussysteminphysiologicalregenerativeandpathologicalconditions
AT cesconmatilde impactofgutmicrobiotaontheperipheralnervoussysteminphysiologicalregenerativeandpathologicalconditions
AT gambarottagiovanna impactofgutmicrobiotaontheperipheralnervoussysteminphysiologicalregenerativeandpathologicalconditions
AT raimondostefania impactofgutmicrobiotaontheperipheralnervoussysteminphysiologicalregenerativeandpathologicalconditions
AT haasterttalinikirsten impactofgutmicrobiotaontheperipheralnervoussysteminphysiologicalregenerativeandpathologicalconditions
AT ronchigiulia impactofgutmicrobiotaontheperipheralnervoussysteminphysiologicalregenerativeandpathologicalconditions