Cargando…
Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions
It has been widely demonstrated that the gut microbiota is responsible for essential functions in human health and that its perturbation is implicated in the development and progression of a growing list of diseases. The number of studies evaluating how the gut microbiota interacts with and influenc...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179357/ https://www.ncbi.nlm.nih.gov/pubmed/37175764 http://dx.doi.org/10.3390/ijms24098061 |
_version_ | 1785041078818177024 |
---|---|
author | Calabrò, Sonia Kankowski, Svenja Cescon, Matilde Gambarotta, Giovanna Raimondo, Stefania Haastert-Talini, Kirsten Ronchi, Giulia |
author_facet | Calabrò, Sonia Kankowski, Svenja Cescon, Matilde Gambarotta, Giovanna Raimondo, Stefania Haastert-Talini, Kirsten Ronchi, Giulia |
author_sort | Calabrò, Sonia |
collection | PubMed |
description | It has been widely demonstrated that the gut microbiota is responsible for essential functions in human health and that its perturbation is implicated in the development and progression of a growing list of diseases. The number of studies evaluating how the gut microbiota interacts with and influences other organs and systems in the body and vice versa is constantly increasing and several ‘gut–organ axes’ have already been defined. Recently, the view on the link between the gut microbiota (GM) and the peripheral nervous system (PNS) has become broader by exceeding the fact that the PNS can serve as a systemic carrier of GM-derived metabolites and products to other organs. The PNS as the communication network between the central nervous system and the periphery of the body and internal organs can rather be affected itself by GM perturbation. In this review, we summarize the current knowledge about the impact of gut microbiota on the PNS, with regard to its somatic and autonomic divisions, in physiological, regenerative and pathological conditions. |
format | Online Article Text |
id | pubmed-10179357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101793572023-05-13 Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions Calabrò, Sonia Kankowski, Svenja Cescon, Matilde Gambarotta, Giovanna Raimondo, Stefania Haastert-Talini, Kirsten Ronchi, Giulia Int J Mol Sci Review It has been widely demonstrated that the gut microbiota is responsible for essential functions in human health and that its perturbation is implicated in the development and progression of a growing list of diseases. The number of studies evaluating how the gut microbiota interacts with and influences other organs and systems in the body and vice versa is constantly increasing and several ‘gut–organ axes’ have already been defined. Recently, the view on the link between the gut microbiota (GM) and the peripheral nervous system (PNS) has become broader by exceeding the fact that the PNS can serve as a systemic carrier of GM-derived metabolites and products to other organs. The PNS as the communication network between the central nervous system and the periphery of the body and internal organs can rather be affected itself by GM perturbation. In this review, we summarize the current knowledge about the impact of gut microbiota on the PNS, with regard to its somatic and autonomic divisions, in physiological, regenerative and pathological conditions. MDPI 2023-04-29 /pmc/articles/PMC10179357/ /pubmed/37175764 http://dx.doi.org/10.3390/ijms24098061 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Calabrò, Sonia Kankowski, Svenja Cescon, Matilde Gambarotta, Giovanna Raimondo, Stefania Haastert-Talini, Kirsten Ronchi, Giulia Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions |
title | Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions |
title_full | Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions |
title_fullStr | Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions |
title_full_unstemmed | Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions |
title_short | Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions |
title_sort | impact of gut microbiota on the peripheral nervous system in physiological, regenerative and pathological conditions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179357/ https://www.ncbi.nlm.nih.gov/pubmed/37175764 http://dx.doi.org/10.3390/ijms24098061 |
work_keys_str_mv | AT calabrosonia impactofgutmicrobiotaontheperipheralnervoussysteminphysiologicalregenerativeandpathologicalconditions AT kankowskisvenja impactofgutmicrobiotaontheperipheralnervoussysteminphysiologicalregenerativeandpathologicalconditions AT cesconmatilde impactofgutmicrobiotaontheperipheralnervoussysteminphysiologicalregenerativeandpathologicalconditions AT gambarottagiovanna impactofgutmicrobiotaontheperipheralnervoussysteminphysiologicalregenerativeandpathologicalconditions AT raimondostefania impactofgutmicrobiotaontheperipheralnervoussysteminphysiologicalregenerativeandpathologicalconditions AT haasterttalinikirsten impactofgutmicrobiotaontheperipheralnervoussysteminphysiologicalregenerativeandpathologicalconditions AT ronchigiulia impactofgutmicrobiotaontheperipheralnervoussysteminphysiologicalregenerativeandpathologicalconditions |