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Consensus Definition of Blood Samples from the Subcategorized Normal Controls in the Korea Biobank Network
A control group is defined as a group of people used for comparison. Depending on the type of study, it can be a group of healthy people or a group not exposed to risk factors. It is important to allow researchers to select the appropriate control participants. The Korea Biobank Project-sponsored bi...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179422/ https://www.ncbi.nlm.nih.gov/pubmed/37176521 http://dx.doi.org/10.3390/jcm12093080 |
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author | Han, Ji Eun Park, Min Kyu Jin, Ju Hyun Lee, Jung Ah Park, Gyeongsin Park, Jong Sook Bae, Han-Ik Yun, Seok Joong Seo, An Na Han, Man-Hoon Lee, Hyoungnam Jeon, Jae-Pil Yu, Ji-In Kim, Soon Sun Cheong, Jae Youn |
author_facet | Han, Ji Eun Park, Min Kyu Jin, Ju Hyun Lee, Jung Ah Park, Gyeongsin Park, Jong Sook Bae, Han-Ik Yun, Seok Joong Seo, An Na Han, Man-Hoon Lee, Hyoungnam Jeon, Jae-Pil Yu, Ji-In Kim, Soon Sun Cheong, Jae Youn |
author_sort | Han, Ji Eun |
collection | PubMed |
description | A control group is defined as a group of people used for comparison. Depending on the type of study, it can be a group of healthy people or a group not exposed to risk factors. It is important to allow researchers to select the appropriate control participants. The Korea Biobank Project-sponsored biobanks are affiliated with the Korea Biobank Network (KBN), for which the National Biobank of Korea plays a central coordinating role among KBN biobanks. KBN organized several working groups to address new challenges and needs in biobanking. The “Normal Healthy Control Working Group” developed standardized criteria for three defined control groups, namely, normal, normal-plus, and disease-specific controls. Based on the consensus on the definition of a normal control, we applied the criteria for normal control participants to retrospective data. The main reason for exclusion from the “Normal-plus” group was blood test results beyond 5% of the reference range, including hypercholesterolemia. Subclassification of samples of normal controls by detailed criteria will help researchers select optimal normal controls for their studies. |
format | Online Article Text |
id | pubmed-10179422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101794222023-05-13 Consensus Definition of Blood Samples from the Subcategorized Normal Controls in the Korea Biobank Network Han, Ji Eun Park, Min Kyu Jin, Ju Hyun Lee, Jung Ah Park, Gyeongsin Park, Jong Sook Bae, Han-Ik Yun, Seok Joong Seo, An Na Han, Man-Hoon Lee, Hyoungnam Jeon, Jae-Pil Yu, Ji-In Kim, Soon Sun Cheong, Jae Youn J Clin Med Brief Report A control group is defined as a group of people used for comparison. Depending on the type of study, it can be a group of healthy people or a group not exposed to risk factors. It is important to allow researchers to select the appropriate control participants. The Korea Biobank Project-sponsored biobanks are affiliated with the Korea Biobank Network (KBN), for which the National Biobank of Korea plays a central coordinating role among KBN biobanks. KBN organized several working groups to address new challenges and needs in biobanking. The “Normal Healthy Control Working Group” developed standardized criteria for three defined control groups, namely, normal, normal-plus, and disease-specific controls. Based on the consensus on the definition of a normal control, we applied the criteria for normal control participants to retrospective data. The main reason for exclusion from the “Normal-plus” group was blood test results beyond 5% of the reference range, including hypercholesterolemia. Subclassification of samples of normal controls by detailed criteria will help researchers select optimal normal controls for their studies. MDPI 2023-04-24 /pmc/articles/PMC10179422/ /pubmed/37176521 http://dx.doi.org/10.3390/jcm12093080 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Han, Ji Eun Park, Min Kyu Jin, Ju Hyun Lee, Jung Ah Park, Gyeongsin Park, Jong Sook Bae, Han-Ik Yun, Seok Joong Seo, An Na Han, Man-Hoon Lee, Hyoungnam Jeon, Jae-Pil Yu, Ji-In Kim, Soon Sun Cheong, Jae Youn Consensus Definition of Blood Samples from the Subcategorized Normal Controls in the Korea Biobank Network |
title | Consensus Definition of Blood Samples from the Subcategorized Normal Controls in the Korea Biobank Network |
title_full | Consensus Definition of Blood Samples from the Subcategorized Normal Controls in the Korea Biobank Network |
title_fullStr | Consensus Definition of Blood Samples from the Subcategorized Normal Controls in the Korea Biobank Network |
title_full_unstemmed | Consensus Definition of Blood Samples from the Subcategorized Normal Controls in the Korea Biobank Network |
title_short | Consensus Definition of Blood Samples from the Subcategorized Normal Controls in the Korea Biobank Network |
title_sort | consensus definition of blood samples from the subcategorized normal controls in the korea biobank network |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179422/ https://www.ncbi.nlm.nih.gov/pubmed/37176521 http://dx.doi.org/10.3390/jcm12093080 |
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